<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0123-9392</journal-id>
<journal-title><![CDATA[Infectio]]></journal-title>
<abbrev-journal-title><![CDATA[Infect.]]></abbrev-journal-title>
<issn>0123-9392</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Infectología.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0123-93922018000300141</article-id>
<article-id pub-id-type="doi">10.22354/in.v22i3.725</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Características clínicas y paraclínicas de recién nacidos con sepsis en un hospital nivel IV en Cali, Colombia]]></article-title>
<article-title xml:lang="en"><![CDATA[Clinical and laboratory characteristics of newborns with sepsis in a level IV hospital in Cali, Colombia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Camacho]]></surname>
<given-names><![CDATA[Pahola]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pino-Escobar]]></surname>
<given-names><![CDATA[Jessica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cleves-Luna]]></surname>
<given-names><![CDATA[Daniela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres-Mosquera]]></surname>
<given-names><![CDATA[Arley]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rosso-Suarez]]></surname>
<given-names><![CDATA[Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ballesteros-Castro]]></surname>
<given-names><![CDATA[Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Fundación Valle del Lili Infectología pediátrica ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Icesi  ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Fundación Valle del Lili Centro de investigaciones clínicas ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Fundación Valle del Lili Neonatología ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2018</year>
</pub-date>
<volume>22</volume>
<numero>3</numero>
<fpage>141</fpage>
<lpage>146</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-93922018000300141&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0123-93922018000300141&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0123-93922018000300141&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo:  Describir las características clínicas y microbiológicas de recién nacidos con sepsis admitidos a UCI neonatal de la Fundación Valle del Lili.  Materiales y métodos:  estudio retrospectivo descriptivo entre los años 2012 y 2015. Se seleccionaron neonatos con diagnóstico de sepsis con más de tres días de manejo antibiótico.  Resultados:  Se analizaron datos de las historias de 569 pacientes. El 37.9% (216) de los neonatos tenían peso al nacimiento &lt;1500 g, 29.2% (166) entre 1500-2500 g, y 33.9% (187) &gt;2500 g. Para un total de 396 (69.6%) pacientes con sepsis temprana, 308 (54.1%) con sepsis tardía. Las características clínicas más comunes fueron las respiratorias. El principal diagnóstico de infección en sepsis tardía fue la bacteremia (46.4%), seguido de la infección asociada al catéter (17.8%). El aislamiento más común para sepsis temprana fue Streptococcus agalactiae en el 21.9%, mientras que en sepsis tardía fue Staphylococcus epidermidis en el 22.6%. La mortalidad encontrada en sepsis temprana fue de 8.8% y en tardía de 8.5%.  Conclusiones:  La sepsis neonatal, a pesar de la mejoría en los controles prenatales, continúa siendo una patología frecuente con un importante porcentaje de morbimortalidad. El Streptococcus agalactiae fue la principal causa de sepsis temprana en nuestros pacientes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective:  To describe the clinical and microbiological characteristics of newborns with sepsis admitted to the Neonatal Intensive Care Unit of Fundación Valle del Lili in Cali, Colombia.  Methods:  Descriptive, observational, retrospective study between 2012 and 2015. We included newborns with diagnosis of sepsis with more than three days of antibiotic management.  Results:  A total of 569 patients were included, 37.9% (216) of the newborns had a birth weight &lt;1500g, 29.2% (166) between 1500 and 2500g , and 32.9% (187) &gt;2500g. 396 (69.6%) patients with early-onset sepsus, 308 (54.1%) had late-onset sepsis. The most common clinical characteristics were respiratory symptoms. The main diagnosis of infection in late-onset sepsis was bacteremia (46.4%) followed by catheter associated infection (17.8%). The most common blood culture isolation for early-onset sepsis was Streptococcus agalactiae (21.9%) and Staphylococcus epidermidis in late onset sepsis (22.6%). The mortality found in early-onset sepsis was 8.8% and in late-onset sepsis was 8.5%.  Conclusions:  Neonatal sepsis continue to be a frequent diagnosis with significant morbidity and mortality. Better strategies for the prevention of this entity are required including the prenatal period.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Sepsis]]></kwd>
<kwd lng="es"><![CDATA[Infección]]></kwd>
<kwd lng="es"><![CDATA[Neonatos]]></kwd>
<kwd lng="en"><![CDATA[Sepsis]]></kwd>
<kwd lng="en"><![CDATA[Infection]]></kwd>
<kwd lng="en"><![CDATA[Newborns]]></kwd>
<kwd lng="en"><![CDATA[Clinic]]></kwd>
<kwd lng="en"><![CDATA[Microbiology.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shane]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neonatal sepsis: Progress towards improved outcomes]]></article-title>
<source><![CDATA[J. Infect]]></source>
<year>2014</year>
<volume>68</volume>
<page-range>S24-32</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Thaver]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Burden of Neonatal Infections in Developing Countries: A Review of Evidence from Community-Based Studies]]></article-title>
<source><![CDATA[Pediatr. Infect. Dis. J]]></source>
<year>2009</year>
<volume>28</volume>
<page-range>S3-9</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Seale]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estimates of possible severe bacterial infection in neonates in sub-Saharan Africa, south Asia, and Latin America for 2012: A systematic review and metaanalysis]]></article-title>
<source><![CDATA[Lancet Infect. Dis]]></source>
<year>2014</year>
<volume>14</volume>
<page-range>731-41</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wynn]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Defining neonatal sepsis]]></article-title>
<source><![CDATA[Curr. Opin. Pediatr]]></source>
<year>2016</year>
<volume>28</volume>
<page-range>135-40</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gaitan]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis neonatal. PRECOP]]></article-title>
<source><![CDATA[Sociedad Colombiana de Pediatría]]></source>
<year>2014</year>
<volume>13</volume>
<page-range>7-26</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Oeser]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical trials in neonatal sepsis]]></article-title>
<source><![CDATA[J Antimicrob Chemother]]></source>
<year>2013</year>
<volume>68</volume>
<page-range>2733-45</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kraj&#269;inovi&#263;]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Risk factors for neonatal sepsis and method for reduction of blood culture contamination]]></article-title>
<source><![CDATA[Malawi Med. J]]></source>
<year>2015</year>
<volume>27</volume>
<page-range>20-4</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[O´Grady]]></surname>
<given-names><![CDATA[NP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Guidelines for the Prevention of Intravascular Catheter-related Infections]]></article-title>
<source><![CDATA[Clin Infect Dis]]></source>
<year>2011</year>
<month>;</month>
<volume>52</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>e162-93</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tsai]]></surname>
<given-names><![CDATA[MH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Recurrent late-onset sepsis in the neonatal intensive care unit: Incidence, clinical characteristics and risk factors]]></article-title>
<source><![CDATA[Clin. Microbiol. Infect]]></source>
<year>2014</year>
<volume>20</volume>
<page-range>O928-35</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shah]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neonatal sepsis: an old problem with new insights]]></article-title>
<source><![CDATA[Virulence]]></source>
<year>2014</year>
<volume>5</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>170-8</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="">
<collab>Ministerio de Salud y Protección Social Colombia</collab>
<collab>Colciencias</collab>
<collab>Universidad Javeriana</collab>
<source><![CDATA[Recién nacido: sepsis neonatal temprana. Guía de práctica clínica]]></source>
<year>2013</year>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sohn]]></surname>
<given-names><![CDATA[AH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalence of nosocomial infections in neonatal intensive care unit patients: Results from the first national point-prevalence survey]]></article-title>
<source><![CDATA[J. Pediatr]]></source>
<year>2001</year>
<volume>139</volume>
<page-range>821-7</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arnon]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Litmanovitz]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diagnostic tests in neonatal sepsis]]></article-title>
<source><![CDATA[Curr. Opin. Infect. Dis]]></source>
<year>2008</year>
<volume>21</volume>
<page-range>223-7</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Raja]]></surname>
<given-names><![CDATA[NS]]></given-names>
</name>
<name>
<surname><![CDATA[Parratt]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Meyers]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Blood culture contamination in a district general hospital in the UK: a 1-year study]]></article-title>
<source><![CDATA[Healthc. Infect]]></source>
<year>2009</year>
<volume>14</volume>
<page-range>95-100</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zea-Vera]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Unificando los criterios de sepsis neonatal tardía: propuesta de un algoritmo de vigilancia diagnóstica]]></article-title>
<source><![CDATA[Rev Peru Med Exp Salud Publica]]></source>
<year>2014</year>
<volume>31</volume>
<page-range>358-63</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saltigeral]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Valenzuela]]></surname>
<given-names><![CDATA[AMC]]></given-names>
</name>
<name>
<surname><![CDATA[Avedaño]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Plascencia]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Agentes causales de sepsis neonatal temprana y tardía: una revisión de diez años en el &#8216;Hospital Infantil Privado&#8217;]]></article-title>
<source><![CDATA[Rev. Enfermedades Infecc. En Pediatr]]></source>
<year>2007</year>
<volume>20</volume>
<page-range>99-105</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bizarro]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Shabanova]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Baltimore]]></surname>
<given-names><![CDATA[RS]]></given-names>
</name>
<name>
<surname><![CDATA[Dembry]]></surname>
<given-names><![CDATA[LM]]></given-names>
</name>
<name>
<surname><![CDATA[Ehernkranz]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[Gallaqher]]></surname>
<given-names><![CDATA[PG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neonatal sepsis 2004-2013: the rise and fall of coagulasenegative staphylococci]]></article-title>
<source><![CDATA[J Pediatr]]></source>
<year>2015</year>
<volume>166</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1193-9</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Seale]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
<name>
<surname><![CDATA[Blencowe]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Zaidi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ganatra]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Syed]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Engmann]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neonatal severe bacterial infection impairment estimates in South Asia, sub-Saharan Africa, and Latin America for 2010]]></article-title>
<source><![CDATA[Pediatr. Res]]></source>
<year>2013</year>
<volume>74</volume>
<numero>^s1</numero>
<issue>^s1</issue>
<supplement>1</supplement>
<page-range>73-85</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
