<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0123-9392</journal-id>
<journal-title><![CDATA[Infectio]]></journal-title>
<abbrev-journal-title><![CDATA[Infect.]]></abbrev-journal-title>
<issn>0123-9392</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Infectología.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0123-93922018000400199</article-id>
<article-id pub-id-type="doi">10.22354/in.v22i4.738</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Artemeter-Lumefantrine therapeutic efficacy, safety and plasma levels in patients with uncomplicated falciparum malaria from the Colombian Pacific region]]></article-title>
<article-title xml:lang="es"><![CDATA[Eficacia terapéutica, seguridad y niveles plasmáticos del Artemeter-Lumefantrine en pacientes con malaria falciparum no complicada de la región del Pacifico Colombiano]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tobón-Castaño]]></surname>
<given-names><![CDATA[Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garcés-Murillo]]></surname>
<given-names><![CDATA[Luisa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ríos-Orrego]]></surname>
<given-names><![CDATA[Alexandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montiel-Ramos]]></surname>
<given-names><![CDATA[Jehidys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[De Las Salas]]></surname>
<given-names><![CDATA[Briegel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mesa-Echeverry]]></surname>
<given-names><![CDATA[Esteban]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Niebles-Bolivar]]></surname>
<given-names><![CDATA[Mayra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Antioquia School of Medicine Malaria Group]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>22</volume>
<numero>4</numero>
<fpage>199</fpage>
<lpage>205</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-93922018000400199&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0123-93922018000400199&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0123-93922018000400199&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  In Colombia, the published studies for the treatment of uncomplicated Plasmodium falciparum malaria with Artemether-Lumefantrine are scarce. The aim of the study was to evaluate the therapeutic efficacy and safety profile of this combination.  Methods:  A clinical trial was performed in adults with uncomplicated P. falciparum malaria using the 28&#8209;day World Health Organization validated protocol. Patients received supervised antimalarial treatment and the primary efficacy endpoint was the clinical and parasitological response. Safety was assessed through adverse events surveillance and plasmatic levels of antimalarial drugs were measured.  Results:  88 patients were included. Adequate clinical and parasitological response rate of 100% on day 28 was achieved in 84 patients, diagnosed by thick blood smear examination. There were four parasitological therapeutic failures (5%) detected by polymerase chain reaction.  Discusion:  Therapeutic efficacy similar to previous studies was established with a slight increase in therapeutic failure. The serum levels of the antimalarials were adequate and the few cases of therapeutic failure were not related.  Conclusion:  Treatment of uncomplicated P. falciparum malaria with Artemeter-Lumefantrine was effective and safe in the study population. All patients reached adequate plasma concentrations of the drugs; therapeutic failures were not associated with low blood levels of the drug clinical trial.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  Son escasos los estudios en Colombia sobre eficacia del tratamiento para Plasmodium falciparum con la combinación Artemeter-Lumefantrina. El objetivo de este estudio fue evaluar la eficacia terapéutica y el perfil de seguridad de este tratamiento combinado.  Métodos:  Se realizó un ensayo clínico en adultos con malaria por P. falciparum no complicada, utilizando el esquema de 28 días recomendado por la Organización Mundial de la Salud (OMS). Los pacientes recibieron el tratamiento supervisado y el desenlace primario evaluado fue la respuesta clínica y parasitológica. La seguridad fue evaluada a través de vigilancia de efectos adversos y medición de niveles plasmáticos del medicamento.  Resultados:  Se incluyeron 88 pacientes. La tasa de curación clínica y parasitológica fue del 100% en 84 pacientes que tuvieron examen de gota gruesa al día 28. Hubo cuatro (5%) fallas parasitológicas detectada por reacción en cadena de polimerasa.  Discusión:  La eficacia terapéutica fue similar a la reportada en estudios previos con un ligero aumento de falla terapéutica. Los niveles plasmáticos de los antimalaricos fueron adecuados y no relacionados con la falla terapéutica.  Conclusión:  El tratamiento de malaria por P. falciparum no complicada con Artemeter-Lumefantrina fue efectiva y segura en la población estudiada. Todos los pacientes alcanzaron niveles en plasma adecuados y no se encontró asociación de falla terapéutica con bajos niveles en sangre.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Malaria]]></kwd>
<kwd lng="en"><![CDATA[Plasmodium falciparum]]></kwd>
<kwd lng="en"><![CDATA[Artemeter-Lumefantrine]]></kwd>
<kwd lng="en"><![CDATA[Efficacy]]></kwd>
<kwd lng="en"><![CDATA[Safety]]></kwd>
<kwd lng="en"><![CDATA[Plasmatic levels]]></kwd>
<kwd lng="es"><![CDATA[Malaria]]></kwd>
<kwd lng="es"><![CDATA[Artemeter]]></kwd>
<kwd lng="es"><![CDATA[Lumefantrina]]></kwd>
<kwd lng="es"><![CDATA[Eficacia]]></kwd>
<kwd lng="es"><![CDATA[Niveles terapéuticos]]></kwd>
<kwd lng="es"><![CDATA[Ensayo clínico]]></kwd>
</kwd-group>
</article-meta>
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