<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0123-9392</journal-id>
<journal-title><![CDATA[Infectio]]></journal-title>
<abbrev-journal-title><![CDATA[Infect.]]></abbrev-journal-title>
<issn>0123-9392</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Infectología.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0123-93922019000100022</article-id>
<article-id pub-id-type="doi">10.22354/in.v23i1.751</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Caracterización de los pacientes con diagnóstico de Histoplasmosis en el Hospital Universitario de San Ignacio entre 2012 a 2016]]></article-title>
<article-title xml:lang="en"><![CDATA[Characterization of patients with clinical diagnosis of Histoplasmosis in the "Hospital Universitario San Ignacio" between 2012-2016]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuéllar]]></surname>
<given-names><![CDATA[Isabel Cristina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garzón]]></surname>
<given-names><![CDATA[Javier Ricardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Velandia]]></surname>
<given-names><![CDATA[Óscar Muñoz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ballén]]></surname>
<given-names><![CDATA[Diego Felipe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Pontificia Universidad Javeriana Hospital Universitario de San Ignacio Departamento de Medicina Interna]]></institution>
<addr-line><![CDATA[Bogotá DC]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>01</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>01</month>
<year>2019</year>
</pub-date>
<volume>23</volume>
<numero>1</numero>
<fpage>22</fpage>
<lpage>26</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-93922019000100022&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0123-93922019000100022&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0123-93922019000100022&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: La histoplasmosis diseminada es una forma de presentación común en pacientes inmunosuprimidos. La introducción de nuevos métodos diagnósticos y la mejoría de la sobrevida de los pacientes con VIH pueden hacer cambiar las características clínicas de los pacientes con esta enfermedad. El objetivo de este estudio es describir las características demográficas, clínicas y métodos diagnósticos para esta enfermedad utilizados en una institución de cuarto nivel de complejidad en Colombia durante los últimos cinco años.  Métodos: Se realizó un estudio observacional tipo serie de casos, incluyendo pacientes con diagnóstico de histoplasmosis manejados en el Hospital Universitario San Ignacio en Bogotá (Colombia) entre enero de 2012 y diciembre de 2016. Los casos fueron identificados utilizando una herramienta automatizada a partir de las historias clínicas electrónicas (DISEARCH).  Resultados: 34 pacientes fueron incluidos, 73,5% con VIH. La enfermedad fue más sintomática en los pacientes con VIH. Los síntomas más frecuentes fueron fiebre y tos (80%), seguidas por diarrea (47%) y manifestaciones cutáneas (35%). El estudio histopatológico fue el método de confirmación más frecuente. El antígeno urinario, fue positivo en el 92.8% de los pacientes a quienes se les realizó la prueba. Las enfermedades autoinmunes fueron la principal causa asociada en pacientes VIH negativos.  Conclusiones: Las características clínicas de los pacientes con histoplasmosis son similares a las descritas en estudios previos en colombia, llamando la atención la alta prevalencia de diarrea y manifestaciones cutáneas. El antígeno urinario para histoplasma y las biopsias cutáneas son excelentes métodos diagnósticos, menos invasivos y con resultados rápidamente disponibles.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Disseminated histoplasmosis is a common presentation in immunosuppressed patients. The introduction of new diagnostic methods and the improvement of the survival of patients with HIV could have changed the clinical characteristics of patients with this disease. The objective of this study is to describe the demographic characteristics, clinical and methods for diagnosis of this disease in a high conplexity institution in Colombia during the last five years.  Methods: A serie of cases was conducted, including patients diagnosed with histoplasmosis managed at the San Ignacio University Hospital in Bogotá (Colombia) between January 2012 and December 2016. The cases were selected using an automatic tool for searching in health electronic records (DISEARCH).  Results: 34 patients were included, 73.5% with HIV. The disease was more symptomatic in patients with HIV. The most frequent symptoms were fever and cough (80%), followed by diarrhea (47%) and skin manifestations (35%). The histopathological study was the most frequent confirmation method. The urinary antigen was positive in 92.8% of the patients, in whom the test was performed. Autoimmune diseases were the main cause associated in HIV negative patients.  Conclusions: The clinical characteristics of patients with histoplasmosis are similar to those described in previous studies in Colombia. It was remarkably the high prevalence of diarrhea and cutaneous manifestations. The urinary antigen for histoplasma and skin biopsies are excellent diagnostic methods, less invasive and with rapidly available results.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Histoplasmosis]]></kwd>
<kwd lng="es"><![CDATA[VIH]]></kwd>
<kwd lng="es"><![CDATA[antígeno urinario]]></kwd>
<kwd lng="es"><![CDATA[PCR]]></kwd>
<kwd lng="es"><![CDATA[Histoplasma]]></kwd>
<kwd lng="es"><![CDATA[Colombia]]></kwd>
<kwd lng="en"><![CDATA[Histoplasmosis]]></kwd>
<kwd lng="en"><![CDATA[HIV]]></kwd>
<kwd lng="en"><![CDATA[urinary antigen]]></kwd>
<kwd lng="en"><![CDATA[PCR Histoplasma]]></kwd>
<kwd lng="en"><![CDATA[Colombia]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wheat]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Azar]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Bahr]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Histoplasmosis]]></article-title>
<source><![CDATA[Infect Dis Clin N Am]]></source>
<year>2016</year>
<volume>30</volume>
<page-range>207-27</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arango]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Castañeda]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Agudelo]]></surname>
<given-names><![CDATA[C.I.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Histoplasmosis: results of the Colombian National Survey, 1992 - 2008]]></article-title>
<source><![CDATA[Biomedica]]></source>
<year>2011</year>
<volume>31</volume>
<page-range>344-56</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pomares]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Gonzalez]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Bohórquez]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A systemic, participative design of decisión support services for clinical research]]></article-title>
<source><![CDATA[Int. J. Inf. Technol. Syst. Approach]]></source>
<year>2014</year>
<volume>7</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>20-40</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pomares]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Gonzalez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Muñoz]]></surname>
<given-names><![CDATA[OM]]></given-names>
</name>
<name>
<surname><![CDATA[Bohorquez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[OM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A Strategy for Prioritizing Electronic Medical Records Using Structured Analysis and Natural Language Processing]]></article-title>
<source><![CDATA[Ingenieria y Universidad]]></source>
<year>2018</year>
<volume>22</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tobón]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Agudelo]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Rosero]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Disseminated Histoplasmosis: A comparative study between patients with acquired immunodeficiency syndrome and non-human inmmunodeficiency virus-infected individuals]]></article-title>
<source><![CDATA[Am. J. Trop. Med. Hyg]]></source>
<year>2005</year>
<volume>73</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>576-82</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cunha]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Zampese]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Aquino]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mucocutaneous manifestations of disseminated histoplasmosis in patients with acquired inmmunodeficiency síndrome: particular aspects in a Latin-american population]]></article-title>
<source><![CDATA[Clin. Exp. Dermatol]]></source>
<year>2007</year>
<volume>32</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>250-5</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wheat]]></surname>
<given-names><![CDATA[L.J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Current diagnosis of Histoplasmosis]]></article-title>
<source><![CDATA[Trends in microbiol]]></source>
<year>2003</year>
<volume>11</volume>
<page-range>488-94</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Muñoz]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Cano]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Detección e identificación de Histoplasma capsulatum por el laboratorio: de los métodos convencionales a las pruebas moleculares]]></article-title>
<source><![CDATA[Infectio]]></source>
<year>2010</year>
<volume>14</volume>
<numero>S2</numero>
<issue>S2</issue>
<page-range>S145-58</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Azar]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Hage]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Laboratory diagnostics for histoplasmosis]]></article-title>
<source><![CDATA[J Clin Microbiol]]></source>
<year>2017</year>
<volume>55</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1612-20</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wheat]]></surname>
<given-names><![CDATA[LJ]]></given-names>
</name>
<name>
<surname><![CDATA[Connolly]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Durkin]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Book]]></surname>
<given-names><![CDATA[BK]]></given-names>
</name>
<name>
<surname><![CDATA[Tector]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Fridell]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Pescovitz]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[False-positive Histoplasma antigenemia caused by antithy-mocyte globulin antibodies]]></article-title>
<source><![CDATA[Transpl Infect Dis]]></source>
<year>2004</year>
<volume>6</volume>
<page-range>23-7</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez-Lazo]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Maquera-Afaray]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Mejía]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Castillo]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Histoplasmosis diseminada e infección por VIH]]></article-title>
<source><![CDATA[Rev Chilena Infectol]]></source>
<year>2017</year>
<volume>34</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>365-9</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[López-Daneri]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Arechavala]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Iovannitti]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Mujica]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Histoplasmosis diseminada en pacientes VIH/SIDA. Buenos Aires. 2009-2014]]></article-title>
<source><![CDATA[Medicina (Buenos Aires)]]></source>
<year>2016</year>
<volume>76</volume>
<page-range>332-7</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Scarcelli]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Miranda]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Espíndola]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Nunes]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical outcomes and risk factors for death from disseminated histoplasmosis in patients with AIDS who visited a high complexity hospital in Campo Grande, MS, Brazil]]></article-title>
<source><![CDATA[Rev Soc Bras Med Trop]]></source>
<year>2018</year>
<volume>51</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>155-61</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
