<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0123-9392</journal-id>
<journal-title><![CDATA[Infectio]]></journal-title>
<abbrev-journal-title><![CDATA[Infect.]]></abbrev-journal-title>
<issn>0123-9392</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Infectología.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0123-93922019000200133</article-id>
<article-id pub-id-type="doi">10.22354/in.v23i2.769</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Uso de procalcitonina como diagnóstico de sepsis o shock séptico: revisión sistemática y metaanálisis]]></article-title>
<article-title xml:lang="en"><![CDATA[Procalcitonin test for diagnosis of sepsis or septic shock: systematic review of literature and metanalysis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Manrique Abril]]></surname>
<given-names><![CDATA[Fred]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendez Fandiño]]></surname>
<given-names><![CDATA[Yardany]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Herrera-Amaya]]></surname>
<given-names><![CDATA[Giomar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodriguez]]></surname>
<given-names><![CDATA[Johana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Manrique-Abril]]></surname>
<given-names><![CDATA[Ricardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Colombia Facultad de Enfermería Departamento de Salud de Colectivos; Universidad Pedagógica y Tecnológica de Colombia, Salud pública]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Pedagógica y Tecnológica de Colombia Escuela de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Pedagógica y Tecnológica de Colombia Escuela de Enfermería ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Pedagógica y Tecnológica de Colombia Escuela de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad Nacional de Colombia Ingeniería ambiental ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<volume>23</volume>
<numero>2</numero>
<fpage>133</fpage>
<lpage>142</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-93922019000200133&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0123-93922019000200133&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0123-93922019000200133&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  La procalcitonina (PCT) es una prohormona de la calcitonina, producida por las células C de la glándula tiroides y convertida intracelularmente por enzimas proteolíticas en la hormona activa. La producción de PCT durante procesos in&#64258;amatorios, está ligada a endotoxinas bacterianas y a citoquinas in&#64258;amatorias. La mortalidad por sepsis, depende en gran medida de la detección precoz y del inicio de una terapia adecuada, incluyendo la administración de antibióticos apropiados, sin embargo, no está claro si el rendimiento diagnóstico de la PCT en el contexto de la nueva definición de sepsis en el tercer consenso es igual que con la definición previa.  Métodos:  Se incluyeron estudios que describieran el uso de PCT dentro de las primeras 24 horas de admisión, como prueba diagnóstica de sepsis. Se realizó la búsqueda en las bases de datos de Medline (Pubmed) y Embase. La calidad metodológica se evaluó según la Colaboración Cochrane en el desarrollo de Revisiones Sistemáticas sobre Test de Análisis para la herramienta QUADAS-II. El sesgo de publicación fue estudiado con el Test de Asimetría de Deeks. Se usó el módulo de MIDAS de STATA 14 para el análisis univariado y la construcción de la Curva de ROC.  Resultados:  Se obtuvieron 2076 registros (783 de Medline y 1293 de Embase). De los 12 estudios seleccionados, se incluyeron un total de 1353 pacientes, con una prevalencia en los estudios revisados entre el 9% y 88%, con un promedio del 47%. La Sensibilidad agrupada fue 0,83% (IC95% (0,74-0,89)) y la Especificidad fue 0,84% (IC95%(0,76-0,89)). El área bajo la Curva fue 0,90 (IC95%(0,87-0,92)). La heterogeneidad entre los estudios es importante I2 88% (IC95%(77-100)). Existe un sesgo de publicación según el test de Deek, con resultado P=0,04. En el análisis sobre la Probabilidad Post test según el nomograma de Fagan, es del 56%, teniendo en cuenta una probabilidad pretest del 20% según el LR positivo 5.  Conclusión:  La PCT es una prueba diagnóstica con buen rendimiento para sepsis o shock séptico, en pacientes adultos, no gestantes. Aunque hay sesgo de publicación y una gran heterogeneidad en los resultados, la prueba se considera adecuada para el escenario de sepsis según las nuevas definiciones.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background:  Procalcitonin (PCT) is a prohormone of calcitonin, produced by cells C of the thyroid gland and intracellurarly cleaved by proteolytic enzymes into the active hormone. The production of PCT during in&#64258;ammatory process, is linked with a bacterial endotoxin and with in&#64258;ammatory cytokines. Mortality due to sepsis, depends to a large extent on a early detection and early start of adecuade therapy, that includes giving appropriate antibiotics. It´s no clear if the PTC diagnostic performance is the same in the context of the definition of the third consensus as in the previous definition.  Methods:  Studies describing the use of PCT within the frst 24 hours of admission as a diagnostic test for sepsis were included. We searched the Medline (Pubmed) and Embase databases. The methodological quality was evaluated according to the Cochrane Collaboration in the development of Systematic Reviews on Analysis Test for the QUADAS-II tool. The publication bias was studied with the Deeks Asymmetry Test. The MIDAS module of STATA 14 was used for the univariate analysis and the construction of the ROC Curve.  Results:  2076 records were obtained (783 from Medline and 1293 from Embase). Of the 12 selected studies, a total of 1353 patients were included, with a prevalence in the studies reviewed between 9% and 88%, with an average of 47%. The pooled sensitivity was 0.83% (CI 95% (0.74-0.89)) and the Specificity was 0.84% (CI 95% (0.76-0.89)). The area under the Curve was 0.90 (CI 95% (0.87-0.92)). Heterogeneity between the studies is important I2 88% (CI 95%(77-100)). There is a publication bias according to the Deek test, with a result of P = 0.04. In the analysis on the post test Probability according to the Fagan nomogram, it is 56%, taking into account a pretest probability of 20% according to the positive LR 5.  Conclusions:  PCT is a diagnostic test with good performance for sepsis or septic shock, in adult patients, not pregnant. Although there is publication bias and great heterogeneity in the results, the test is considered adequate for the sepsis setting according to the new definitions.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Procalcitonina]]></kwd>
<kwd lng="es"><![CDATA[Sepsis]]></kwd>
<kwd lng="es"><![CDATA[Shock séptico]]></kwd>
<kwd lng="es"><![CDATA[diagnostico]]></kwd>
<kwd lng="es"><![CDATA[meta análisis]]></kwd>
<kwd lng="en"><![CDATA[Procalcitonin]]></kwd>
<kwd lng="en"><![CDATA[Sepsis]]></kwd>
<kwd lng="en"><![CDATA[Septic Shock]]></kwd>
<kwd lng="en"><![CDATA[diagnostic]]></kwd>
<kwd lng="en"><![CDATA[meta-analysis]]></kwd>
</kwd-group>
</article-meta>
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