<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0123-9392</journal-id>
<journal-title><![CDATA[Infectio]]></journal-title>
<abbrev-journal-title><![CDATA[Infect.]]></abbrev-journal-title>
<issn>0123-9392</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Infectología.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0123-93922025000100051</article-id>
<article-id pub-id-type="doi">10.22354/24223794.1216</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Tuberculosis multirresistente en adolescente: A propósito de un caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Multidrug-resistant tuberculosis in adolescents: A case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Agudelo]]></surname>
<given-names><![CDATA[Lorena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Velasco-Castro]]></surname>
<given-names><![CDATA[Julio César]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A4"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Holguín-Barrera]]></surname>
<given-names><![CDATA[Mónica Liseth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A5"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Regional de la Orinoquía  ]]></institution>
<addr-line><![CDATA[Yopal ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Regional de la Orinoquía  ]]></institution>
<addr-line><![CDATA[Yopal ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,https://orcid.org/0000-0001-9557-0900  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af4">
<institution><![CDATA[,http://orcid.org/0000-0003-3580-8221  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af5">
<institution><![CDATA[,http://orcid.org/0000-0001-7925-3999  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2025</year>
</pub-date>
<volume>29</volume>
<numero>1</numero>
<fpage>51</fpage>
<lpage>53</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-93922025000100051&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0123-93922025000100051&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0123-93922025000100051&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La resistencia a los fármacos antituberculosos es cada vez más frecuente y afecta actualmente a la población general en todo el mundo, comprometiendo tanto a casos nuevos de tuberculosis, como a los previamente tratados, se requieren esquemas de tratamiento específicos con varios medicamentos de segunda línea por un periodo largo de tiempo para lograr la conversión bacteriológica, convirtiéndolo en un desafío para los médicos tratantes por cuanto son medicamentos que generan muchos efectos adversos, lo cual impacta negativamente en la adherencia al tratamiento. A continuación, se presenta el caso de una adolescente a quien se le diagnosticó una tuberculosis multirresistente, el cual se manejó de acuerdo con los lineamientos nacionales con dos medicamentos del grupo A y dos medicamentos del grupo B, (por no disponibilidad de Bedaquilina), comprobando resistencia negativa a los fármacos de segunda línea y estableciendo una adherencia y tolerancia adecuada al tratamiento e importante al seguimiento.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Resistance to anti-tuberculosis drugs is becoming increasingly frequent and currently affects the general population worldwide, compromising both new cases of tuberculosis and those previously treated, requiring specific treatment schemes with several second-line drugs for a long period of time to achieve bacteriological conversion, making it a challenge for treating physicians as these drugs generate many adverse effects that negatively impact adherence to treatment. The following is the case of an adolescent girl diagnosed with multidrug-resistant tuberculosis, which was managed according to national guidelines with two group A drugs and two group B drugs (due to the unavailability of bedaquiline), proving negative resistance to second-line drugs and establishing adequate adherence and tolerance to treatment and, importantly, to follow-up.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Tuberculosis]]></kwd>
<kwd lng="es"><![CDATA[mutaciones]]></kwd>
<kwd lng="es"><![CDATA[adolescente]]></kwd>
<kwd lng="es"><![CDATA[TB-MDR]]></kwd>
<kwd lng="en"><![CDATA[Tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[Mutations]]></kwd>
<kwd lng="en"><![CDATA[Adolescence]]></kwd>
<kwd lng="en"><![CDATA[Tuberculosis Multidrug-resistant]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Hughes]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Schaaf]]></surname>
<given-names><![CDATA[HS]]></given-names>
</name>
</person-group>
<source><![CDATA[Expert Rev Respir Med]]></source>
<year>2021</year>
<volume>15</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>221-37</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
