<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0124-7107</journal-id>
<journal-title><![CDATA[Universidad y Salud]]></journal-title>
<abbrev-journal-title><![CDATA[Univ. Salud]]></abbrev-journal-title>
<issn>0124-7107</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Nariño]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0124-71072019000300191</article-id>
<article-id pub-id-type="doi">10.22267/rus.192103.155</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Detección de la alteración del metabolismo glucídico y resistencia a la insulina en una muestra piloto infantil: Aproximación metabolómica]]></article-title>
<article-title xml:lang="en"><![CDATA[Detection of impaired glucidic metabolism and insulin resistance in a pilot child sample]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mauro-Martin]]></surname>
<given-names><![CDATA[Ismael San]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Oliva]]></surname>
<given-names><![CDATA[Sara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garicano-Vilar]]></surname>
<given-names><![CDATA[Elena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Angulo]]></surname>
<given-names><![CDATA[Belén García-de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Blumenfeld-Olivares]]></surname>
<given-names><![CDATA[Javier Andrés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centros de Investigación en Nutrición y Salud  ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital El Escorial Servicio de Endocrinología Pediátrica ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>21</volume>
<numero>3</numero>
<fpage>191</fpage>
<lpage>197</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0124-71072019000300191&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0124-71072019000300191&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0124-71072019000300191&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  La metabolómica permite estudiar la resistencia a insulina (RI), un factor de riesgo de pre-diabetes y diabetes. Quantose IR  TM es el único test que mide la RI mediante la abrazadera hiperinsulinémica euglicémica.  Objetivo:  Se comprobó la eficacia de un test metabolómico en la detección de marcadores de RI en población infantil.  Materiales ymétodos:  Once niños, de edad 8,54±3,53 años y con factores de riesgo de diabetes, fueron reclutados del Hospital El Escorial. Se estableció como criterio diagnóstico para la prediabetes el estándar de la Asociación Americana de Diabetes (ADA) (HbA1C 5,7-6,4% y glucosa basal 100-125mg/dl). Se compararon las analíticas de sangre con la prueba de Quantose IR  TM , estudiando el perfil del metaboloma relacionado con la RI (ácido alfa-hidroxibutírico, ácido oleico, linoleo-glicerofosfocolina e insulina). Su análisis generó una puntuación Quantose  © (escala 0-100), siendo &gt;63 RI.  Resultados:  Ningún sujeto cumplió el criterio de la ADA para prediabetes: HbA1C fue 5,3±0,18 % y glucosa 86,6±5,6 mg/dl. Por el contrario, 10 sujetos cumplieron criterios del test Quantose IR  TM para la RI (score: 78,09 ± 9,24 (&gt;63)).  Conclusiones:  El test Quantose IR  TM mide el porcentaje de hemoglobina unida a glucosa dentro de los glóbulos rojos. Permite prever el riesgo de diabetes, y tomar medidas preventivas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  Metabolomics enables the study of insulin resistance (IR), a risk factor for pre-diabetes and diabetes. Quantose IRTM is the only test that measures IR using the euglycemic hyperinsulinemic clamp.  Objective: The effectiveness of a metabolomic test for the detection of RI markers in a child population was verified.  Materials and methods:  Eleven children aged 8.54 ± 3.53 years with diabetes risk factors were recruited from the El Escorial Hospital. The American Diabetes Association (ADA) Standards (5,7-6,4% HbA1C and 100-125 mg/dl basal glucose) were established as diagnostic criteria for prediabetes. Blood tests were compared to the Quantose IRTM assay studying the metabolomic profile related to IR (alpha-hydroxybutyric acid, oleic acid, linoleo-glycerophosphocoline and insulin). This analysis generated a Quantose © score of IR &gt; 63.  Results:  None of the subjects met the ADA criteria for prediabetes: HbA1C=5,3±0,18 and glucose=86,6± 5,6 mg/dl. On the contrary, 10 subjects met the Quantose IRTM test criterion for IR (score: 78,09 ± 9,24 (&gt;63)).  Conclusions:  The Quantose IRTM test measures the percentage of glucose bound hemoglobin within red blood cells. This assay makes it possible to predict diabetes risk and take preventive measures.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Diabetes mellitus]]></kwd>
<kwd lng="es"><![CDATA[resistencia a la insulina]]></kwd>
<kwd lng="es"><![CDATA[metabolómica]]></kwd>
<kwd lng="es"><![CDATA[metabolismo de los hidratos de carbono]]></kwd>
<kwd lng="es"><![CDATA[niño]]></kwd>
<kwd lng="en"><![CDATA[Diabetes mellitus]]></kwd>
<kwd lng="en"><![CDATA[insulin resistance]]></kwd>
<kwd lng="en"><![CDATA[metabolomics]]></kwd>
<kwd lng="en"><![CDATA[carbohydrate metabolism]]></kwd>
<kwd lng="en"><![CDATA[child]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Manzur]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Rodriguez]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Yañez]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
<name>
<surname><![CDATA[Ortuño]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandez]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Síndrome metabólico, factores de riesgo en niños y adolescentes con sobrepeso]]></article-title>
<source><![CDATA[Gac méd Boliv]]></source>
<year>2016</year>
<volume>39</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>94-8</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<collab>van der Aa MP.Fazeli Farsani S.Knibbe CAJ.de Boer A.van der Vorst MMJ</collab>
<article-title xml:lang=""><![CDATA[Population-Based Studies on the Epidemiology of Insulin Resistance in Children]]></article-title>
<source><![CDATA[J Diabetes Res]]></source>
<year>2015</year>
<volume>2015</volume>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fernando Carrasco]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Síndrome de resistencia a la insulina Estudio y manejo]]></article-title>
<collab>José Eduardo Galgani F.Marcela Reyes J</collab>
<source><![CDATA[Rev Médica Clínica Las Condes]]></source>
<year>2015</year>
<volume>24</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>827-37</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tokarz]]></surname>
<given-names><![CDATA[VL]]></given-names>
</name>
<name>
<surname><![CDATA[MacDonald]]></surname>
<given-names><![CDATA[PE]]></given-names>
</name>
<name>
<surname><![CDATA[Klip]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The cell biology of systemic insulin function]]></article-title>
<source><![CDATA[J Cell Biol]]></source>
<year>2018</year>
<volume>217</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>1-17</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Galgani]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[Ravussin]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Postprandial whole-body glycolysis is similar in insulin-resistant and insulin-sensitive non-diabetic humans]]></article-title>
<source><![CDATA[Diabetologia]]></source>
<year>2012</year>
<volume>55</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>737-42</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jeffery]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
<name>
<surname><![CDATA[Hosking]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Jeffery]]></surname>
<given-names><![CDATA[AN]]></given-names>
</name>
<name>
<surname><![CDATA[Murphy]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Voss]]></surname>
<given-names><![CDATA[LD]]></given-names>
</name>
<name>
<surname><![CDATA[Wilkin]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Gender differences in insulin resistance during adolescence A longitudinal study (EarlyBird)]]></article-title>
<source><![CDATA[Diabetologia]]></source>
<year>2016</year>
<volume>59</volume>
<page-range>S547</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Galera Martínez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[García García]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Vázquez López]]></surname>
<given-names><![CDATA[MÁ]]></given-names>
</name>
<name>
<surname><![CDATA[Ortiz Pérez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[López Ruzafa]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Martín González]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Factores asociados a insulinemia en población general adolescente]]></article-title>
<source><![CDATA[Nutr Hosp]]></source>
<year>2013</year>
<volume>28</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1610-4</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bajaj]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[DeFronzo]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metabolic and molecular basis of insulin resistance]]></article-title>
<source><![CDATA[J Nucl Cardiol]]></source>
<year>2003</year>
<volume>10</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>311-23</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Weickert]]></surname>
<given-names><![CDATA[MO]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[What dietary modification best improves insulin sensitivity and why]]></article-title>
<source><![CDATA[Clin Endocrinol (Oxf)]]></source>
<year>2012</year>
<volume>77</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>508-12</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Calero Bernal]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Varela Aguilar]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diabetes tipo 2 infantojuvenil]]></article-title>
<source><![CDATA[Rev Clínica Española]]></source>
<year>2018</year>
<volume>218</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>372-81</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Manrique-Hurtado]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Aro-Guardia]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Pinto-Valdivia]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diabetes tipo 2 en niños Serie de casos]]></article-title>
<source><![CDATA[Rev Medica Hered]]></source>
<year>2016</year>
<volume>26</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>5-9</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gómez-Ambrosi]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Catalán]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Frühbeck]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Papel del tejido adiposo en la inflamación asociada a la obesidad]]></article-title>
<source><![CDATA[Rev Esp Obes]]></source>
<year>2008</year>
<volume>6</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>264-79</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kao]]></surname>
<given-names><![CDATA[KT]]></given-names>
</name>
<name>
<surname><![CDATA[Sabin]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Type 2 diabetes mellitus in children and adolescents]]></article-title>
<source><![CDATA[Aust Fam Physician]]></source>
<year>2016</year>
<volume>45</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>401-6</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arisaka]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Sairenchi]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Ichikawa]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Koyama]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Increase of body mass index (BMI) from 1 5 to 3 years of age augments the degree of insulin resistance corresponding to BMI at 12 years of age]]></article-title>
<source><![CDATA[J Pediatr Endocrinol Metab]]></source>
<year>2017</year>
<volume>30</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>455-7</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rosas-Sumano]]></surname>
<given-names><![CDATA[AB]]></given-names>
</name>
<name>
<surname><![CDATA[Rodal-Canales]]></surname>
<given-names><![CDATA[FJ]]></given-names>
</name>
<name>
<surname><![CDATA[Barrientos Pérez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Cárdenas-Morales]]></surname>
<given-names><![CDATA[BE]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez-Campos Mayoral]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez-Campos]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hiperinsulinemia y resistencia insulínica en niños de dos escuelas públicas de Oaxaca, México]]></article-title>
<source><![CDATA[Rev Med Chil]]></source>
<year>2016</year>
<volume>144</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>1020-8</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="book">
<collab>International Diabetes Federation</collab>
<source><![CDATA[IDF Diabetes Atlas Eighth edition 2017]]></source>
<year>2017</year>
<publisher-loc><![CDATA[Brussels ]]></publisher-loc>
<publisher-name><![CDATA[Internatinal Diabetes Federation]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lehmann]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diabetes subphenotypes and metabolomics The key to discovering laboratory markers for personalized medicine?. Clin]]></article-title>
<source><![CDATA[Chem]]></source>
<year>2013</year>
<volume>59</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1294-6</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brown]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Yanovski]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estimation of insulin sensitivity in children Methods, measures and controversies]]></article-title>
<source><![CDATA[Pediatr Diabetes]]></source>
<year>2014</year>
<volume>15</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>151-61</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lentferink]]></surname>
<given-names><![CDATA[YE]]></given-names>
</name>
<name>
<surname><![CDATA[Elst]]></surname>
<given-names><![CDATA[MAJ]]></given-names>
</name>
<name>
<surname><![CDATA[Knibbe]]></surname>
<given-names><![CDATA[CAJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Predictors of Insulin Resistance in Children versus Adolescents with Obesity]]></article-title>
<collab>van der Vorst MMJ</collab>
<source><![CDATA[J Obes]]></source>
<year>2017</year>
<volume>2017</volume>
<page-range>3793868</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Katz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Nambi]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
<name>
<surname><![CDATA[Mather]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Baron]]></surname>
<given-names><![CDATA[AD]]></given-names>
</name>
<name>
<surname><![CDATA[Follmann]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
<name>
<surname><![CDATA[Sullivan]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Quantitative insulin sensitivity check index A simple, accurate method for assessing insulin sensitivity in humans]]></article-title>
<source><![CDATA[J Clin Endocrinol Metab]]></source>
<year>2000</year>
<volume>85</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>2402-10</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gutch]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Razi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gupta]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Gupta]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Assessment of insulin sensitivity/resistance]]></article-title>
<source><![CDATA[Indian J Endocrinol Metab]]></source>
<year>2015</year>
<volume>19</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>160</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cobb]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Gall]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Adam]]></surname>
<given-names><![CDATA[KP]]></given-names>
</name>
<name>
<surname><![CDATA[Nakhle]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Button]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Hathorn]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A novel fasting blood test for insulin resistance and prediabetes]]></article-title>
<source><![CDATA[J Diabetes Sci Technol]]></source>
<year>2013</year>
<volume>7</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>100-10</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cobb]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Eckhart]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Motsinger-Reif]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Carr]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Groop]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diabetes]]></article-title>
<collab>Ferrannini E a-Hydroxybutyric acid is a selective metabolite biomarker of impaired glucose tolerance</collab>
<source><![CDATA[Care]]></source>
<year>2016</year>
<volume>39</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>988-95</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<collab>American Diabetes Association</collab>
<article-title xml:lang=""><![CDATA[2 Classification and diagnosis of Diabetes: Standards of Medical Care in diabetes - 2019]]></article-title>
<source><![CDATA[Diabetes Care]]></source>
<year>2019</year>
<volume>42</volume>
<numero>Suppl 1</numero>
<issue>Suppl 1</issue>
<page-range>S13-28</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gonzalez-Neira]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[San Mauro-Martin]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Garcia-Angulo]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Fajardo]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Garicano-Vilar]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nutritional and body composition assessment and its relationship with athletic performance in a women's soccer team]]></article-title>
<source><![CDATA[Rev Esp Nutr Humana Y Diet]]></source>
<year>2015</year>
<volume>19</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>36-48</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[TANITA]]></surname>
<given-names><![CDATA[CORPORATION]]></given-names>
</name>
</person-group>
<source><![CDATA[Body Fat Moitor / Scale. Instruction Manual Tanita]]></source>
<year>2011</year>
<publisher-loc><![CDATA[Illinois ]]></publisher-loc>
<publisher-name><![CDATA[Tanita Corporation of America Inc]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gunczler]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Síndrome de resistencia a la insulina en niños y adolescentes]]></article-title>
<source><![CDATA[Gac Med Caracas]]></source>
<year>2006</year>
<volume>114</volume>
<page-range>62-70</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Milburn M]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Lawton]]></surname>
<given-names><![CDATA[KA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Application of Metabolomics to Diagnosis of Insulin Resistance]]></article-title>
<source><![CDATA[Annu Rev Med]]></source>
<year>2013</year>
<volume>64</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>291-305</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Scalbert]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Brennan]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Fiehn]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Hankemeier]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Kristal]]></surname>
<given-names><![CDATA[BS]]></given-names>
</name>
<name>
<surname><![CDATA[van Ommen]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mass-spectrometry-based metabolomics Limitations and recommendations for future progress with particular focus on nutrition research]]></article-title>
<source><![CDATA[Metabolomics]]></source>
<year>2009</year>
<volume>5</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>435-58</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gall]]></surname>
<given-names><![CDATA[WE]]></given-names>
</name>
<name>
<surname><![CDATA[Beebe]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Lawton]]></surname>
<given-names><![CDATA[KA]]></given-names>
</name>
<name>
<surname><![CDATA[Adam]]></surname>
<given-names><![CDATA[KP]]></given-names>
</name>
<name>
<surname><![CDATA[Mitchell]]></surname>
<given-names><![CDATA[MW]]></given-names>
</name>
<name>
<surname><![CDATA[Nakhle]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[PLoS]]></article-title>
<collab>et al a-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population</collab>
<source><![CDATA[One]]></source>
<year>2010</year>
<volume>5</volume>
<numero>5</numero>
<issue>5</issue>
</nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ferrannini]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Natali]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Camastra]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Nannipieri]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mari]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Adam]]></surname>
<given-names><![CDATA[KP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance]]></article-title>
<source><![CDATA[Diabetes]]></source>
<year>2013</year>
<volume>62</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1730-7</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
