<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0304-3584</journal-id>
<journal-title><![CDATA[Actualidades Biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[Actu Biol]]></abbrev-journal-title>
<issn>0304-3584</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Biología, Universidad de Antioquia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0304-35842017000200014</article-id>
<article-id pub-id-type="doi">10.17533/udea.acbi.v39n107a02</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[El reto inmunológico con promastigotes de Leishmania (Viannia) panamensis en Galleria mellonella modula cambios en los perfiles de expresión de proteínas de bajo peso molecular]]></article-title>
<article-title xml:lang="en"><![CDATA[Galleria mellonella immunological challenge with Leishmania promastigotes triggers changes on the profile expression of low molecular weight proteins]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Patiño-Márquez]]></surname>
<given-names><![CDATA[Isabel A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Manrique-Moreno]]></surname>
<given-names><![CDATA[Marcela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Villa]]></surname>
<given-names><![CDATA[Laura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortíz-Reyes]]></surname>
<given-names><![CDATA[Blanca]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Patiño-González]]></surname>
<given-names><![CDATA[Edwin]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Antioquia  ]]></institution>
<addr-line><![CDATA[Medellín Antioquia]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Antioquia  ]]></institution>
<addr-line><![CDATA[Medellín Antioquia]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<volume>39</volume>
<numero>107</numero>
<fpage>14</fpage>
<lpage>23</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0304-35842017000200014&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0304-35842017000200014&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0304-35842017000200014&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El parásito Leishmania es responsable de varias enfermedades que afectan humanos y animales en más de 95 países, incluido Colombia. Es conocida la toxicidad que presentan drogas como el Glucantime y la Anfotericina B, usadas en el tratamiento contra este parásito. Los péptidos antimicrobianos (PAMs) son considerados agentes prometedores contra un amplio espectro de enfermedades infecciosas, siendo potenciales agentes terapéuticos con una baja toxicidad. Los PAMs son parte de la respuesta inmune de insectos, de donde han sido aislados, demostrando tener actividad antibacteriana y anti-fúngica. La polilla Galleria mellonella expresa un amplio repertorio de péptidos como respuesta al reto con diversos organismos, lo que sugiere una alternativa para la obtención de péptidos con actividad antiparasitaria. Este estudio utilizó un reto inmunológico con promastigotes de Leishmania (Viannia) panamensis sobre larvas de Galleria mellonella para la búsqueda de fracciones peptídicas con actividad antiparasitaria. La hemolinfa fue obtenida de larvas control, inoculadas con PBS y retadas con parásitos. La hemolinfa libre de hemocitos de cada tratamiento fue analizada por electroforesis de dos dimensiones (gel 2D). Además, la hemolinfa fue fraccionada por RP-HPLC. El análisis del gel 2D identificó cuatro señales (manchas) en la hemolinfa retada y 3 señales en la hemolinfa con PBS. Estas señales no se encontraron en la hemolinfa control. Por otro lado, fracciones de RP-HPLC de la hemolinfa retada mostraron más actividad leishmanicida en comparación con las mismas fracciones de la hemolinfa control. Esta aproximación puede proveer nuevos péptidos contra Leishmania.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The Leishmania parasite is responsible for several diseases that affect humans and animals in more than 95 countries including Colombia. Despite the known toxicity shown by current drugs such as Glucantime or Amphotericin B, they are still used as treatments against the parasite. Natural antimicrobial peptides (AMPs) are considered promising agents for use against a broad spectrum of infectious diseases, they are considered promising and non-toxic therapeutic agents. AMPs are part of the immune response of organisms such as insects, from where they have been isolated and shown to have antibacterial and antifungal activity. Galleria mellonella moths express a broad repertoire of peptides in response to challenges with different organisms. This suggests an alternative for obtaining peptides with anti-parasitic activity. This study was based on the immunological challenge induced in Galleria mellonella larvae with Leishmania (viannia) panamensis promastigotes, with the goal of isolating a peptide fraction with antiparasitic activity. Non-challenged hemolymph and hemolymph obtained from the immunization with PBS and parasites were compared. Free hemocyte hemolymph from each treatment was analyzed by two-dimensional electrophoresis (2D gel). Furthermore, hemolymphs were fractionated by RP-HPLC. 2D gel analysis identified 4 spots in challenged hemolymph and 3 spots in PBS hemolymph. These spots were not present in the control hemolymph. On the other hand, fractions from RPHPLC of challenged hemolymph showed more antileishmania activity in comparison to the same fractions from the hemolymph control. This study may provide the basis for new antileishmanial peptides.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Hemolinfa]]></kwd>
<kwd lng="es"><![CDATA[electroforesis 2D]]></kwd>
<kwd lng="es"><![CDATA[G. mellonella]]></kwd>
<kwd lng="es"><![CDATA[Leishmania]]></kwd>
<kwd lng="es"><![CDATA[PAMs]]></kwd>
<kwd lng="es"><![CDATA[Perfiles proteicos]]></kwd>
<kwd lng="en"><![CDATA[Hemolymph]]></kwd>
<kwd lng="en"><![CDATA[2D Electrophoresis]]></kwd>
<kwd lng="en"><![CDATA[G. mellonella]]></kwd>
<kwd lng="en"><![CDATA[Leishmania]]></kwd>
<kwd lng="en"><![CDATA[AMPs]]></kwd>
<kwd lng="en"><![CDATA[Protein profiles]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Andrejko]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mizerska-Dudka]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Jakubowicz]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antibacterial activity in vivo and in vitro in the hemolymph of Galleria mellonella infected with Pseudomonas aeruginosa]]></article-title>
<source><![CDATA[Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology]]></source>
<year>2009</year>
<volume>152</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>118-23</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bergin]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Murphy]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Keenan]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Clynes]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kavanagh]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pre-exposure to yeast protects larvae of Galleria mellonella from a subsequent lethal infection by Candida albicans and is mediated by the increased expression of antimicrobial peptides]]></article-title>
<source><![CDATA[Microbes and Infection]]></source>
<year>2006</year>
<volume>8</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>2105-12</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Blum]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Desjeux]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Schwartz]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Beck]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Hatz]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Treatment of cutaneous Leishmaniosis among travellers]]></article-title>
<source><![CDATA[The Journal of Antimicrobial Chemotherapy]]></source>
<year>2004</year>
<volume>53</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>158-66</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Boulanger]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Lowenberger]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Volf]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Ursic]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Sigutova]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Sabatier]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Svobodova]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Beverley]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[Spath]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Brun]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Pesson]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Bulet]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Characterization of a defensin from the sand fly Phlebotomus duboscqi induced by challenge with bacteria or the protozoan parasite Leishmania Major]]></article-title>
<source><![CDATA[Infection and Immunity]]></source>
<year>2004</year>
<volume>72</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>7140-6</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brey]]></surname>
<given-names><![CDATA[PT]]></given-names>
</name>
<name>
<surname><![CDATA[Lee W]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Yamakawa]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Koizumi]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Perrot]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[François]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ashida]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Role of the integument in insect immunity: epicuticular abrasion and induction of cecropin synthesis in cuticular epithelial cells]]></article-title>
<source><![CDATA[Proceedings of the National Academy of Sciences of the United States of America]]></source>
<year>1993</year>
<volume>90</volume>
<numero>13</numero>
<issue>13</issue>
<page-range>6275-9</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brogden]]></surname>
<given-names><![CDATA[KA]]></given-names>
</name>
<name>
<surname><![CDATA[Ackermann]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[McCray]]></surname>
<given-names><![CDATA[PB]]></given-names>
</name>
<name>
<surname><![CDATA[Tack]]></surname>
<given-names><![CDATA[BF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antimicrobial peptides in animals and their role in host defences]]></article-title>
<source><![CDATA[International Journal of Antimicrobial Agents]]></source>
<year>2003</year>
<volume>22</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>465-78</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brown]]></surname>
<given-names><![CDATA[SE]]></given-names>
</name>
<name>
<surname><![CDATA[Howard]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kasprzak]]></surname>
<given-names><![CDATA[AB]]></given-names>
</name>
<name>
<surname><![CDATA[Gordon K]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[East]]></surname>
<given-names><![CDATA[PD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The discovery and analysis of a diverged Family of Novel Antifungal Moricin-like Peptides in the Wax Moth Galleria Mellonella]]></article-title>
<source><![CDATA[Insect biochemistry and Molecular Biology]]></source>
<year>2008</year>
<volume>38</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>201-12</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brown]]></surname>
<given-names><![CDATA[SE]]></given-names>
</name>
<name>
<surname><![CDATA[Howard]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kasprzak]]></surname>
<given-names><![CDATA[AB]]></given-names>
</name>
<name>
<surname><![CDATA[Gordon]]></surname>
<given-names><![CDATA[KH]]></given-names>
</name>
<name>
<surname><![CDATA[East]]></surname>
<given-names><![CDATA[PD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A Peptidomics Study Reveals the Impressive Antimicrobial Peptide Arsenal of the Wax Moth Galleria Mellonella]]></article-title>
<source><![CDATA[Insect biochemistry and Molecular Biology]]></source>
<year>2009</year>
<volume>39</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>792-800</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bulet]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Charlet]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Hetru]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antimicrobial Peptides in Insect Immunity]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Ezekowitz]]></surname>
<given-names><![CDATA[RAB]]></given-names>
</name>
<name>
<surname><![CDATA[Hoffmann]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<source><![CDATA[Innate Inmunity]]></source>
<year>2003</year>
<page-range>410 (89-107)</page-range><publisher-loc><![CDATA[Totowa (U.S.A) ]]></publisher-loc>
<publisher-name><![CDATA[Humana Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chicharro]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Granata]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Lozano]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Andreu]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Rivas]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[N-Terminal Fatty Acid Substitution increases the leishmanicidal activity of CA(1-7) M(2-9), a Cecropin-Melittin Hybrid Peptide]]></article-title>
<source><![CDATA[Antimicrobial Agents and Chemotherapy]]></source>
<year>2001</year>
<volume>45</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>2441-9</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cook]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[McArthur]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Developing Galleria mellonella as a model host for human pathogens]]></article-title>
<source><![CDATA[Virulence]]></source>
<year>2013</year>
<volume>4</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>350-3</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cytry&#324;ska]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mak]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Zdybicka-Barabas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Suder]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Jakubowicz]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Purification and characterization of eight peptides from Galleria mellonella immune hemolymph]]></article-title>
<source><![CDATA[Peptides]]></source>
<year>2007</year>
<volume>28</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>533-46</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Díaz-Achirica]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Ubach]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Guinea]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Andreu]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Rivas]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Plasma Membrane of Leishmania Donovani Promastigotes Is the Main Target for CA(1-8) M(1-18), a Synthetic Cecropin A-Melittin Hybrid Peptide]]></article-title>
<source><![CDATA[The Biochemical Journal]]></source>
<year>1998</year>
<volume>330</volume>
<numero>Pt 1</numero>
<issue>Pt 1</issue>
<page-range>453-60</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Frézard]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Demicheli]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Ribeiro]]></surname>
<given-names><![CDATA[RR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pentavalent antimonials: new perspectives for old drugs]]></article-title>
<source><![CDATA[Molecules (Basel, Switzerland)]]></source>
<year>2009</year>
<volume>14</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>2317-36</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hancock]]></surname>
<given-names><![CDATA[REW]]></given-names>
</name>
<name>
<surname><![CDATA[Sahl]]></surname>
<given-names><![CDATA[HG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies]]></article-title>
<source><![CDATA[Nature Biotechnology]]></source>
<year>2006</year>
<volume>24</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1551-7</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hoffmann]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Hetru]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Insect defensins: Inducible antibacterial peptides]]></article-title>
<source><![CDATA[Immunology Today]]></source>
<year>1992</year>
<volume>13</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>411-5</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lewis]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Phlebotomid sandflies]]></article-title>
<source><![CDATA[Bulletin of the World Health Organization]]></source>
<year>1971</year>
<volume>44</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>535-51</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mak]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Zdybicka-Barabas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cytry&#324;ska]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A different repertoire of Galleria mellonella antimicrobial peptides in larvae challenged with bacteria and fungi]]></article-title>
<source><![CDATA[Developmental and Comparative Immunology]]></source>
<year>2010</year>
<volume>34</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1129-36</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Olliaro]]></surname>
<given-names><![CDATA[PL]]></given-names>
</name>
<name>
<surname><![CDATA[Bryceson]]></surname>
<given-names><![CDATA[AD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Practical progress and new drugs for changing patterns of Leishmaniosis]]></article-title>
<source><![CDATA[Parasitology Today]]></source>
<year>1993</year>
<volume>9</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>323-8</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rogers]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[Ilg]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Nikolaev]]></surname>
<given-names><![CDATA[AV]]></given-names>
</name>
<name>
<surname><![CDATA[Ferguson]]></surname>
<given-names><![CDATA[MAJ]]></given-names>
</name>
<name>
<surname><![CDATA[Bates]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Transmission of cutaneous Leishmaniosis by sand flies is enhanced by regurgitation of fPPG]]></article-title>
<source><![CDATA[Nature]]></source>
<year>2004</year>
<volume>430</volume>
<numero>6998</numero>
<issue>6998</issue>
<page-range>463-7</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schoofs]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Holman]]></surname>
<given-names><![CDATA[GM]]></given-names>
</name>
<name>
<surname><![CDATA[Hayes]]></surname>
<given-names><![CDATA[TK]]></given-names>
</name>
<name>
<surname><![CDATA[Nachman]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[De Loof]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Locustatachykinin I and II, two novel insect neuropeptides with homology to peptides of the vertebrate tachykinin family]]></article-title>
<source><![CDATA[FEBS letters]]></source>
<year>1990</year>
<volume>261</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>397-401</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sundar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Chakravarty]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antimony toxicity]]></article-title>
<source><![CDATA[International Journal of Environmental Research and Public Health]]></source>
<year>2010</year>
<volume>7</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>4267-77</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[de Vries]]></surname>
<given-names><![CDATA[HJC]]></given-names>
</name>
<name>
<surname><![CDATA[Reedijk]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
<name>
<surname><![CDATA[Schallig]]></surname>
<given-names><![CDATA[HDFH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cutaneous Leishmaniosis: recent developments in diagnosis and management]]></article-title>
<source><![CDATA[American Journal of Clinical Dermatology]]></source>
<year>2015</year>
<volume>16</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>99-109</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="">
<collab>WHO</collab>
<source><![CDATA[Organización mundial de la salud, Leishmaniosis (internet)]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wojda]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Patryk-Kowalski]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Jakubowicz]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Humoral immune response of Galleria mellonella larvae after infection by Beauveria bassiana under optimal and heat-shock conditions]]></article-title>
<source><![CDATA[Journal of Insect Physiology]]></source>
<year>2009</year>
<volume>55</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>525-31</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wortmann]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Zapor]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ressner]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Fraser]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Hartzell]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Pierson]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Weintrob]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Magill]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lipsosomal amphotericin B for treatment of cutaneous Leishmaniosis]]></article-title>
<source><![CDATA[The American Journal of Tropical Medicine and Hygiene]]></source>
<year>2010</year>
<volume>83</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1028-33</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wyatt]]></surname>
<given-names><![CDATA[GR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The biochemistry of insect hemolymph]]></article-title>
<source><![CDATA[Annual Review of Entomology]]></source>
<year>1961</year>
<volume>6</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>75-102</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yeaman]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
<name>
<surname><![CDATA[Yount]]></surname>
<given-names><![CDATA[NY]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mechanisms of antimicrobial peptide action and resistance]]></article-title>
<source><![CDATA[Pharmacological Reviews]]></source>
<year>2003</year>
<volume>55</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>27-55</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Liang]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Zheng]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Engineering antimicrobial peptides with improved antimicrobial and hemolytic activities]]></article-title>
<source><![CDATA[Journal of Chemical Information and Modeling]]></source>
<year>2013</year>
<volume>53</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>3280-96</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
