<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1657-4702</journal-id>
<journal-title><![CDATA[Revista Latinoamericana de Bioética]]></journal-title>
<abbrev-journal-title><![CDATA[rev.latinoam.bioet.]]></abbrev-journal-title>
<issn>1657-4702</issn>
<publisher>
<publisher-name><![CDATA[Universidad Militar Nueva Granada]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1657-47022022000200051</article-id>
<article-id pub-id-type="doi">10.18359/rlbi.5592</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Perspectiva bioética para México, España y Estados Unidos en los modelos in vivo de inducción de daño al ADN]]></article-title>
<article-title xml:lang="en"><![CDATA[Bioethical perspective for Mexico, Spain, and the United States in in-vivo models of DNA damage induction.]]></article-title>
<article-title xml:lang="pt"><![CDATA[Perspectiva bioética para México, Espanha e Estados Unidos nos modelos in-vivo de indução de dano ao DNA]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez Guerson]]></surname>
<given-names><![CDATA[Giovanni Aleksey]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Linares Márquez]]></surname>
<given-names><![CDATA[Pascual]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pascual Mathey]]></surname>
<given-names><![CDATA[Luz Irene]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Veracruzana  ]]></institution>
<addr-line><![CDATA[Xalapa Ver]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Veracruzana Facultad de Biología ]]></institution>
<addr-line><![CDATA[Xalapa Ver]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Veracruzana Facultad de Química Farmacéutica Biológica ]]></institution>
<addr-line><![CDATA[Xalapa Ver]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<volume>22</volume>
<numero>2</numero>
<fpage>51</fpage>
<lpage>64</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S1657-47022022000200051&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S1657-47022022000200051&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S1657-47022022000200051&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: En la actualidad, la investigación biomédica se ha centrado en el estudio de enfermedades como el cáncer, que causan un elevado índice de mortalidad. Existen diferentes modelos animales, empleados para generar diversos tipos de carcinogénesis; el daño directo al ADN es uno de los mecanismos más utilizados. Sin embargo, en la normatividad nacional e internacional vigente, no se señalan los aspectos bioéticos que se deben seguir para desarrollar un modelo experimental de daño al ADN. Además, no se realiza una correcta semejanza de la enfermedad. Debido a lo anterior, esta revisión analiza los avances en cuanto a normatividad que se han generado en diferentes países, comparando los estudios encontrados en Estados Unidos, México y España. La perspectiva a futuro es poder contar con guías de experimentación actualizadas, que permitan pautar las normas necesarias para el adecuado desarrollo de los modelos de investigación animal de daño al ADN y que cumplan con la regla de las 3R en la experimentación animal. Esta iniciativa se debe de realizar en conjunto entre la Organización Mundial de la Salud y los organismos especializados en manejo y cuidado de animales de laboratorio en los ámbitos nacional e internacional.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Currently, biomedical research has focused on the study of diseases such as cancer that causes a high mortality rate. Different animal models are used to generate different types of carcinogenesis; direct DNA damage is one of the most used mechanisms. However, current national and international regulations do not indicate the bioethical aspects that must be followed to develop an experimental model of DNA damage. In addition, they do not perform a correct resemblance of the disease. Due to the above, this review analyzes the advances in regulations generated in different countries, comparing the studies found in the United States, Mexico, and Spain. The future perspective is to be able to count on updated experimentation guidelines, which allow the establishment of the necessary norms for the adequate development of animal research models of DNA damage that comply with the 3R rule in animal experimentation. This initiative should be carried out jointly by the World Health Organization and organizations specialized in managing and caring laboratory animals at the national and international levels.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo: Na atualidade, a pesquisa biomédica vem se focando no estudo de doenças que causam um elevado índice de mortalidade, como o câncer. Existem diferentes modelos animais utilizados para gerar diversos tipos de carcinogêneses; o dano direto ao DNA é um dos mecanismos mais utilizados. Contudo, na legislação nacional e internacional vigente, não são sinalizados os aspectos bioéticos que devem ser seguidos para desenvolver um modelo experimental de dano ao DNA, além de não ser realizada uma correta semelhança da doença. Devido a isso, esta revisão analisa o avanço quanto à legislação que vem sendo gerada em diferentes países, comparando os estudos encontrados nos Estados Unidos, no México e na Espanha. A perspectiva para o futuro é poder contar com atualizadas, que permitam estabelecer as normas necessárias para desenvolver os modelos de pesquisa animal de dano ao DNA e que cumpram com a regra das 3R na experimentação animal. Essa iniciativa se deve realizar em conjunto entre a Organização Mundial da Saúde e as organizações especializadas na gestão e cuidado de animais de laboratório nos contextos nacional e internacional.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[modelos in vivo]]></kwd>
<kwd lng="es"><![CDATA[daño al ADN]]></kwd>
<kwd lng="es"><![CDATA[modelos animales]]></kwd>
<kwd lng="es"><![CDATA[bioética]]></kwd>
<kwd lng="es"><![CDATA[normas]]></kwd>
<kwd lng="es"><![CDATA[seguridad]]></kwd>
<kwd lng="en"><![CDATA[in vivo models]]></kwd>
<kwd lng="en"><![CDATA[DNA damage]]></kwd>
<kwd lng="en"><![CDATA[animal models]]></kwd>
<kwd lng="en"><![CDATA[bioethics]]></kwd>
<kwd lng="en"><![CDATA[standards]]></kwd>
<kwd lng="en"><![CDATA[safety]]></kwd>
<kwd lng="pt"><![CDATA[modelos in vivo]]></kwd>
<kwd lng="pt"><![CDATA[dano ao DNA]]></kwd>
<kwd lng="pt"><![CDATA[modelos animais]]></kwd>
<kwd lng="pt"><![CDATA[bioética]]></kwd>
<kwd lng="pt"><![CDATA[normas]]></kwd>
<kwd lng="pt"><![CDATA[segurança]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barrios]]></surname>
<given-names><![CDATA[EE]]></given-names>
</name>
<name>
<surname><![CDATA[Espinoza]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Leal]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Ruiz]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Pinto]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Jurado]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bioética y el empleo de animales de experimentación en investigación]]></article-title>
<source><![CDATA[Salus]]></source>
<year>2011</year>
<volume>15</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>28-34</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Benavides]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Guénet]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Modelos murinos de enfermedades humanas]]></article-title>
<source><![CDATA[Medicina (B. Aires)]]></source>
<year>2000</year>
<volume>61</volume>
<numero>512</numero>
<issue>512</issue>
<page-range>215-31</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Villela-Cortés]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Reflexión sobre la justificación metodológica del uso de animales en investigación biomédica]]></article-title>
<source><![CDATA[Rev Col Bioét]]></source>
<year>2019</year>
<volume>4</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Osorio]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ética en la investigación con modelos animales experimentales. Alternativas y las 3 RS de Russel. Una responsabilidad y un compromiso ético que nos compete a todos]]></article-title>
<source><![CDATA[Rev Col Bioét]]></source>
<year>2006</year>
<volume>1</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="">
<collab>Conbioética</collab>
<source><![CDATA[Ética de la investigación con animales]]></source>
<year>2015</year>
<volume>IV</volume>
<numero>16</numero>
<issue>16</issue>
<publisher-loc><![CDATA[México ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shaw]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bioethics in the Age of Globalization]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Soniewicka]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[The Ethics of Reproductive Genetics]]></source>
<year>2018</year>
</nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Baker]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Animal registries aim to reduce bias]]></article-title>
<source><![CDATA[Nature]]></source>
<year>2019</year>
<volume>573</volume>
<numero>7773</numero>
<issue>7773</issue>
<page-range>297-8</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[NP]]></given-names>
</name>
<name>
<surname><![CDATA[Colaço]]></surname>
<given-names><![CDATA[AA]]></given-names>
</name>
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Animal models as a tool in hepatocellular carcinoma research: A Review]]></article-title>
<source><![CDATA[Tumour Biol]]></source>
<year>2017</year>
<volume>39</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>1010428317695923</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[LY]]></given-names>
</name>
<name>
<surname><![CDATA[Ma]]></surname>
<given-names><![CDATA[XZ]]></given-names>
</name>
<name>
<surname><![CDATA[Ouyang]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Ings]]></surname>
<given-names><![CDATA[DP]]></given-names>
</name>
<name>
<surname><![CDATA[Marwah]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nanoparticle Uptake in a Spontaneous and Immunocompetent Woodchuck Liver Cancer Model]]></article-title>
<source><![CDATA[ACS Nano]]></source>
<year>2020</year>
<volume>14</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>4698-715</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Herrera]]></surname>
<given-names><![CDATA[UMC]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández]]></surname>
<given-names><![CDATA[RY]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[PI]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estandarización de un modelo de cáncer de colon en ratones BALB/c]]></article-title>
<source><![CDATA[Rev Ciencias Médicas]]></source>
<year>2016</year>
<volume>20</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>671-82</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Moctezuma Viera]]></surname>
<given-names><![CDATA[KR]]></given-names>
</name>
<name>
<surname><![CDATA[Linares Márquez]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Utilización de animales en la investigación biomédica y médica: Un estudio preliminar]]></article-title>
<source><![CDATA[RIB]]></source>
<year>2020</year>
<numero>12</numero>
<issue>12</issue>
<page-range>01-9</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Abdul-Hamid]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Moustafa]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Protective effect of curcumin on histopathology and ultrastructure of pancreas in the alloxan treated rats for induction of diabetes]]></article-title>
<source><![CDATA[The Journal of Basic y Applied Zoology]]></source>
<year>2013</year>
<volume>66</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>169-79</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Morton]]></surname>
<given-names><![CDATA[DB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Punto final humanitario en la experimentación animal para la investigación biomédica: aspectos éticos, legales y prácticos]]></article-title>
<source><![CDATA[Lab Anim]]></source>
<year>2005</year>
<numero>8</numero>
<issue>8</issue>
<page-range>5-12</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Van Dyke]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cancer modeling in the modern era: progress and challenges]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Jacks]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<source><![CDATA[Cell]]></source>
<year>2002</year>
<volume>108</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>135-44</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Parker]]></surname>
<given-names><![CDATA[LS]]></given-names>
</name>
</person-group>
<source><![CDATA[]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="">
<collab>Secretaría de Agricultura, Desarrollo Rural, Pesca y Alimentación</collab>
<source><![CDATA[Norma Oficial Mexicana NOM 062-ZOO-1999, Especificaciones técnicas para la producción, cuidado y uso de los animales de laboratorio]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hubrecht]]></surname>
<given-names><![CDATA[RC]]></given-names>
</name>
<name>
<surname><![CDATA[Kirkwood]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[The UFAW handbook on the care and management of laboratory and other research animals]]></source>
<year>2010</year>
<publisher-name><![CDATA[John Wiley y Sons]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="">
<source><![CDATA[Tribunal Internacional de Núremberg, Código de Núremberg]]></source>
<year>1947</year>
</nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jankoski Gauto-Quintana]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The role of bioethics in animal ethics commissions]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Luciane-Fischer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev Bioét]]></source>
<year>2019</year>
<volume>27</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>549-65</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="">
<collab>Asociación Médica Mundial</collab>
<source><![CDATA[Declaración de Helsinki]]></source>
<year>1964</year>
</nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Andersen]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Winter]]></surname>
<given-names><![CDATA[LMF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Animal models in biological and biomedical research - experimental and ethical concerns]]></article-title>
<source><![CDATA[An Acad Bras Cienc]]></source>
<year>2019</year>
<volume>91</volume>
<numero>^s1</numero>
<issue>^s1</issue>
<supplement>1</supplement>
</nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amrithaa]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Lakshminarayanan]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Geetha]]></surname>
<given-names><![CDATA[RV]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ethical aspects of medical research in human and animals]]></article-title>
<source><![CDATA[J Arch.Egyptol]]></source>
<year>2020</year>
<volume>17</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>3403-9</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Weiss]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Shannon]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mouse cancer models as a platform for performing preclinical therapeutic trials]]></article-title>
<source><![CDATA[Curr Opin Genet Dev]]></source>
<year>2003</year>
<volume>13</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>84-9</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Benavides]]></surname>
<given-names><![CDATA[FJ]]></given-names>
</name>
<name>
<surname><![CDATA[Guénet]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<source><![CDATA[Manual de genética de roedores de laboratorio: Principios básicos y aplicaciones. Los roedores de laboratorio como modelos de enfermedades humanas]]></source>
<year>2014</year>
<page-range>288-92</page-range><publisher-loc><![CDATA[Alcalá ]]></publisher-loc>
<publisher-name><![CDATA[Universidad de Alcalá]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kwisda]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[White]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Hübner]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ethical arguments concerning human-animal chimera research: a systematic review]]></article-title>
<source><![CDATA[BMC Med Ethics]]></source>
<year>2020</year>
<volume>21</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>24</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Santos de Dios]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The use of animal models in cancer research]]></article-title>
<source><![CDATA[Rev Oncol]]></source>
<year>2002</year>
<numero>4</numero>
<issue>4</issue>
<page-range>55-8</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Baksheev]]></surname>
<given-names><![CDATA[AI]]></given-names>
</name>
<name>
<surname><![CDATA[Turchina]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Galaktionova]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gusarenko]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Rakhinsky]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Shepeleva]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bioethical principles and mechanisms for regulation of biomedical research]]></article-title>
<source><![CDATA[IJPSDR]]></source>
<year>2018</year>
<volume>10</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>889-92</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stepke]]></surname>
<given-names><![CDATA[FL]]></given-names>
</name>
</person-group>
<source><![CDATA[Ética e innovación tecnológica. Centro Interdisciplinario de Estudios en Bioética (CIEB). Vicerrectoría de Investigación y Desarrollo]]></source>
<year>2006</year>
<edition>1</edition>
<publisher-name><![CDATA[Universidad de Chile]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Padrón]]></surname>
<given-names><![CDATA[APP]]></given-names>
</name>
<name>
<surname><![CDATA[Gil]]></surname>
<given-names><![CDATA[FDR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Which bioethical and bio-legal guidelines should be followed when performing pharmacogenetic and pharmacogenomic tests in psychiatry clinical trials in Colombia, to protect genetic data and the rights of research subjects?]]></article-title>
<source><![CDATA[Rev Col Psiq]]></source>
<year>2021</year>
<volume>50</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>57-63</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Ramos]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Zamora]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
<name>
<surname><![CDATA[Sáenz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Consideraciones bioéticas en la investigación del dolor en animales de experimentación]]></article-title>
<source><![CDATA[Investigación en Salud]]></source>
<year>2003</year>
<numero>5</numero>
<issue>5</issue>
<page-range>1-7</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Richie]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[Principles of Green Bioethics: Sustainability in Health Care]]></source>
<year>2019</year>
<publisher-name><![CDATA[Michigan State University Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Creux]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Diaz]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Grynberg]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Papaxanthos-Roche]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Chansel-Debordeaux]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Jimenez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[National survey on the opinions of French specialists in assisted reproductive technologies about social issues impacting the future revision of the French Bioethics laws]]></article-title>
<source><![CDATA[J Gynecol Obstet Hum Reprod]]></source>
<year>2020</year>
<volume>49</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>101902</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kottow]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Conflictos en ética de investigación con seres humanos]]></article-title>
<source><![CDATA[Cad. Saúde Pública]]></source>
<year>2005</year>
<volume>21</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>862-9</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Siurana Aparisi]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Los principios de la bioética y el surgimiento de una bioética intercultural]]></article-title>
<source><![CDATA[Veritas]]></source>
<year>2010</year>
<numero>22</numero>
<issue>22</issue>
<page-range>121-57</page-range></nlm-citation>
</ref>
<ref id="B35">
<label>35</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brodbelt]]></surname>
<given-names><![CDATA[DC]]></given-names>
</name>
<name>
<surname><![CDATA[Blissitt]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
<name>
<surname><![CDATA[Hammond]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[Neath]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Young]]></surname>
<given-names><![CDATA[LE]]></given-names>
</name>
<name>
<surname><![CDATA[Pfeiffer]]></surname>
<given-names><![CDATA[DU]]></given-names>
</name>
<name>
<surname><![CDATA[Wood]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The risk of death: the confidential enquiry into perioperative small animal fatalities]]></article-title>
<source><![CDATA[Vet Anaesth Analg]]></source>
<year>2008</year>
<volume>35</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>365-73</page-range></nlm-citation>
</ref>
<ref id="B36">
<label>36</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pavarini]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[McMillan]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Robinson]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Singh]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Design bioethics: a theoretical framework and argument for innovation in bioethics research]]></article-title>
<source><![CDATA[Am J Bioeth]]></source>
<year>2021</year>
<volume>21</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>37-50</page-range></nlm-citation>
</ref>
<ref id="B37">
<label>37</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Polaino-Lorente]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Manual de Bioética General]]></source>
<year>1994</year>
<edition>3</edition>
<publisher-loc><![CDATA[Madrid ]]></publisher-loc>
<publisher-name><![CDATA[Rialp]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B38">
<label>38</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kabene]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Baadel]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bioethics: a look at animal testing in medicine and cosmetics in the UK]]></article-title>
<source><![CDATA[J Med Ethics Hist Med]]></source>
<year>2019</year>
<volume>12</volume>
<page-range>15</page-range></nlm-citation>
</ref>
<ref id="B39">
<label>39</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rodríguez-Yunta]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ética de la investigación en modelos animales de enfermedades humanas]]></article-title>
<source><![CDATA[Acta bioethica]]></source>
<year>2007</year>
<volume>13</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>25-40</page-range></nlm-citation>
</ref>
<ref id="B40">
<label>40</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shansky]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Are hormones a "female problem" for animal research?]]></article-title>
<source><![CDATA[Science]]></source>
<year>2019</year>
<volume>364</volume>
<numero>6443</numero>
<issue>6443</issue>
<page-range>825-6</page-range></nlm-citation>
</ref>
<ref id="B41">
<label>41</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saxena]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ethics in Science: An Inquiry into Bioethical Issues]]></article-title>
<source><![CDATA[Ethics in Science]]></source>
<year>2019</year>
<page-range>19-48</page-range><publisher-loc><![CDATA[Springer ]]></publisher-loc>
<publisher-name><![CDATA[Singapore]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B42">
<label>42</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cossio-Bolaños]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez Campos]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Vargas Vitoria]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Hochmuller Fogaça]]></surname>
<given-names><![CDATA[RT]]></given-names>
</name>
<name>
<surname><![CDATA[Arruda]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Curvas de referencia para valorar el crecimiento físico de ratas machos Wistar]]></article-title>
<source><![CDATA[Nutrición Hospitalaria]]></source>
<year>2013</year>
<volume>28</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>2151-6</page-range></nlm-citation>
</ref>
<ref id="B43">
<label>43</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Navarro]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Ramírez]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[Villagrán]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[Manual de procedimientos recomendables para la investigación con animales]]></source>
<year>2012</year>
<publisher-loc><![CDATA[México ]]></publisher-loc>
<publisher-name><![CDATA[Samsara]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B44">
<label>44</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Russell]]></surname>
<given-names><![CDATA[WMS]]></given-names>
</name>
<name>
<surname><![CDATA[Burch]]></surname>
<given-names><![CDATA[RL]]></given-names>
</name>
</person-group>
<source><![CDATA[The Principles of Humane Experimental Technique]]></source>
<year>1959</year>
<publisher-loc><![CDATA[Londres ]]></publisher-loc>
<publisher-name><![CDATA[Methuen]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B45">
<label>45</label><nlm-citation citation-type="">
<collab>APHIS-USDA</collab>
<source><![CDATA[Ley de bienestar animal (AWA)]]></source>
<year>1966</year>
</nlm-citation>
</ref>
<ref id="B46">
<label>46</label><nlm-citation citation-type="book">
<collab>National Research Council</collab>
<source><![CDATA[Guide for the care and use of laboratory animals: A report of the Institute of Laboratory Animal Resource Committee on the Care and Use of Laboratory Animals. NIH Publication No. 85-23]]></source>
<year>1996</year>
<publisher-loc><![CDATA[Washington, D.C. ]]></publisher-loc>
<publisher-name><![CDATA[U.S. Department of health and human Services]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B47">
<label>47</label><nlm-citation citation-type="journal">
<collab>National Research Council</collab>
<article-title xml:lang=""><![CDATA[Humane endpoints for animal used in biomedical research and testing]]></article-title>
<source><![CDATA[ILAR Journal]]></source>
<year>2000</year>
<volume>41</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B48">
<label>48</label><nlm-citation citation-type="">
<source><![CDATA[Servicio de Inspección de Sanidad Animal y Vegetal del Departamento de Agricultura de los EE. UU (APHIS)]]></source>
<year>2001</year>
</nlm-citation>
</ref>
<ref id="B49">
<label>49</label><nlm-citation citation-type="">
<source><![CDATA[Oficina de Bienestar Animal de Laboratorio (OLAW)]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B50">
<label>50</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saracci]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Wild]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[International Agency for Research on Cancer: the first 50 years, 1965-2015 (Community Dentistry and Oral Epidemiology)]]></source>
<year>2015</year>
<publisher-loc><![CDATA[Lyon ]]></publisher-loc>
<publisher-name><![CDATA[IARC]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B51">
<label>51</label><nlm-citation citation-type="">
<source><![CDATA[Agents classified by the IARC monographs]]></source>
<year>2012</year>
<volume>1-104</volume>
<page-range>1-112</page-range></nlm-citation>
</ref>
<ref id="B52">
<label>52</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gold]]></surname>
<given-names><![CDATA[LS]]></given-names>
</name>
<name>
<surname><![CDATA[Slone]]></surname>
<given-names><![CDATA[TH]]></given-names>
</name>
<name>
<surname><![CDATA[Manley]]></surname>
<given-names><![CDATA[NB]]></given-names>
</name>
<name>
<surname><![CDATA[Bernstein]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Target organs in chronic bioassays of 533 chemical carcinogens]]></article-title>
<source><![CDATA[Environ Health Perspect]]></source>
<year>1991</year>
<numero>93</numero>
<issue>93</issue>
<page-range>233-46</page-range></nlm-citation>
</ref>
<ref id="B53">
<label>53</label><nlm-citation citation-type="book">
<source><![CDATA[U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program. Report on Carcinogens]]></source>
<year>2011</year>
<edition>12</edition>
<page-range>507</page-range><publisher-name><![CDATA[Research Triangle Park, NC: US Department of Health and Human Services, Public Health Service]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B54">
<label>54</label><nlm-citation citation-type="book">
<collab>National Toxicology Program (NTP)</collab>
<source><![CDATA[Report on carcinogens]]></source>
<year>2014</year>
<edition>13</edition>
<publisher-name><![CDATA[Research Triangle Park, NC: US Department of Health and Human Services, Public Health Service]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B55">
<label>55</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[ChK]]></surname>
<given-names><![CDATA[Akins]]></given-names>
</name>
<name>
<surname><![CDATA[Panicker]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[ChrL]]></surname>
<given-names><![CDATA[Cunningham]]></given-names>
</name>
</person-group>
<source><![CDATA[Laboratory Animals in Research and teaching: Ethics, Care, and Methods]]></source>
<year>2005</year>
<publisher-loc><![CDATA[Washington ]]></publisher-loc>
<publisher-name><![CDATA[American Psychological Association]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B56">
<label>56</label><nlm-citation citation-type="">
<collab>American Psychological Association</collab>
<source><![CDATA[Guidelines for Ethical Conduct in the Care Use of Animals. Developed by the American Psychological Association Committee on Animal Research and Ethics (CARE)]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B57">
<label>57</label><nlm-citation citation-type="">
<collab>Nuffield council of Bioethics</collab>
<source><![CDATA[The Ethics of Research Involving Animals: A Review of the Nuffield Council on Bioethics Report from a Three Rs Perspective Alternatives to Laboratory Animals]]></source>
<year>2005</year>
<volume>33</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>659-62</page-range></nlm-citation>
</ref>
<ref id="B58">
<label>58</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Singer]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Animal Research II. Philosophical Issues]]></source>
<year>1995</year>
<publisher-loc><![CDATA[Nueva York ]]></publisher-loc>
<publisher-name><![CDATA[Simon and Schuster Macmillan]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B59">
<label>59</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Suckow]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Weisbroth]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
<name>
<surname><![CDATA[Franklin]]></surname>
<given-names><![CDATA[CL]]></given-names>
</name>
</person-group>
<source><![CDATA[The laboratory rat]]></source>
<year>2005</year>
<publisher-name><![CDATA[Elsevier]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B60">
<label>60</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barnett]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
</person-group>
<source><![CDATA[The rat: A study in behavior]]></source>
<year>2007</year>
<publisher-loc><![CDATA[Nueva Jersey ]]></publisher-loc>
<publisher-name><![CDATA[Transaction Publishers]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B61">
<label>61</label><nlm-citation citation-type="">
<collab>Stanford University</collab>
<source><![CDATA[Research Compliance Office. Guidelines for Endpoint Monitoring and Humane Termination. The Administrative Panel on Laboratory Animal Care (A-PLAC)]]></source>
<year>2002</year>
</nlm-citation>
</ref>
<ref id="B62">
<label>62</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[De Aluja]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Animales de laboratorio y la Norma Oficial Mexicana (NOM-062-ZOO-1999)]]></article-title>
<source><![CDATA[Gac Méd Méx]]></source>
<year>2002</year>
<volume>138</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>295-8</page-range></nlm-citation>
</ref>
<ref id="B63">
<label>63</label><nlm-citation citation-type="book">
<collab>Boletín oficial del principado de Asturias</collab>
<source><![CDATA[Reglamento del Comité de Ética en la Investigación]]></source>
<year>2001</year>
<numero>141</numero>
<issue>141</issue>
<publisher-name><![CDATA[Universidad de Oviedo]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B64">
<label>64</label><nlm-citation citation-type="">
<source><![CDATA[Ley 32/2007, de 7 de noviembre, para el cuidado de los animales, en su explotación, transporte, experimentación y sacrificio. Jefatura del Estado «BOE» núm. 268, de 8 de noviembre de 2007 Referencia: BOE-A-2007-19321]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B65">
<label>65</label><nlm-citation citation-type="">
<collab>Instituto Navarro de Salud Laboral</collab>
<source><![CDATA[Guía técnica para la Protección de los trabajadores contra los riesgos relacionados con la exposición a agentes cancerígenos o mutágenos durante el trabajo]]></source>
<year>2006</year>
<edition>3</edition>
</nlm-citation>
</ref>
<ref id="B66">
<label>66</label><nlm-citation citation-type="">
<collab>BOE</collab>
<source><![CDATA[Para la evaluación y prevención de los riesgos relacionados con la exposición a agentes cancerígenos o mutágenos durante el trabajo. Real Decreto 665/1997, de 12 de mayo n° 124, del 24 de mayo]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B67">
<label>67</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Huertas]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Riesgos de exposición a agentes cancerígenos. Prevención de riesgos laborales]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B68">
<label>68</label><nlm-citation citation-type="">
<collab>Council of Europe</collab>
<source><![CDATA[Guía para los Miembros de los Comités de Ética de Investigación]]></source>
<year>2012</year>
</nlm-citation>
</ref>
<ref id="B69">
<label>69</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mann]]></surname>
<given-names><![CDATA[SP]]></given-names>
</name>
<name>
<surname><![CDATA[Treit]]></surname>
<given-names><![CDATA[PV]]></given-names>
</name>
<name>
<surname><![CDATA[Geyer]]></surname>
<given-names><![CDATA[PE]]></given-names>
</name>
<name>
<surname><![CDATA[Omenn]]></surname>
<given-names><![CDATA[GS]]></given-names>
</name>
<name>
<surname><![CDATA[Mann]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ethical Principles, Constraints and Opportunities in Clinical Proteomics]]></article-title>
<source><![CDATA[Mol Cell Proteomics]]></source>
<year>2021</year>
<numero>20</numero>
<issue>20</issue>
<page-range>100046</page-range></nlm-citation>
</ref>
<ref id="B70">
<label>70</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Munshi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Sharma]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<source><![CDATA[Safety and ethics in biotechnology and bioengineering: What to follow and what not to. In Omics Technologies and Bio-Engineering]]></source>
<year></year>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
