1657-5997 1657-5997 S1657-59972022000402243 10.5294/aqui.2022.22.4.3 Brasil Brasil Brasil Brasil Portugal Brasil 00 12 2022 00 12 2022 22 4

1 2020 395 10228 10228 922 2 2020 324 14 14 1389-90 3 2021 12 2 2 75-82 4 2020 25 9 9 3465-74 5 2020 45 45 6 World Health Organization 7 World Health Organization (WHO) International Labor Organization 2021 8 2015 9 2018 19 2 2 34-52 10 2015 68 6 6 1103-8 11 2017 47 165 165 12 Brasil. Conselho Nacional de Saúde Brasil. Comissão Nacional de Ética em Pesquisa 14 2020 371 371 15 2020 370 370 16 2016 5 3 3 341-69 17 2019 30 5 5 101304 18 2001 19 2016 16 1 1 24-31 20 2021 55 55 21 2020 37 5 5 799-805 22 2020 37 37 23 2020 24