<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1657-9534</journal-id>
<journal-title><![CDATA[Colombia Médica]]></journal-title>
<abbrev-journal-title><![CDATA[Colomb. Med.]]></abbrev-journal-title>
<issn>1657-9534</issn>
<publisher>
<publisher-name><![CDATA[Universidad del Valle]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1657-95342016000400178</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Gene editing using CRISPR-Cas9 for the treatment of lung cancer]]></article-title>
<article-title xml:lang="es"><![CDATA[Edición de genes usando CRISPR-Cas9 para el tratamiento del cáncer de pulmón]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castillo]]></surname>
<given-names><![CDATA[Andres]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Del Valle Facultad de Ciencias Naturales y Exactas Departamento de Biologia]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universida del Valle Revista Colombia Médica ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<volume>47</volume>
<numero>4</numero>
<fpage>178</fpage>
<lpage>180</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S1657-95342016000400178&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S1657-95342016000400178&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S1657-95342016000400178&amp;lng=en&amp;nrm=iso"></self-uri></article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Breakthrough of the Year: CRISPR makes the cut]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Travis]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Science Magazine]]></source>
<year>2015</year>
</nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[CRISPR gene-editing tested in a person for the first time]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cyranoski]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>2016</year>
<volume>539</volume>
<page-range>479</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ishino]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Shinagawa]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Makino]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Amemura]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Nakata]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Journal of Bacteriology]]></source>
<year>1987</year>
<volume>169</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>5429-33</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Long stretches of short tandem repeats are present in the largest replicons of the Archaea Haloferax mediterranei and Haloferax volcanii and could be involved in replicon partitioning]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mojica]]></surname>
<given-names><![CDATA[FJ]]></given-names>
</name>
<name>
<surname><![CDATA[Ferrer]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Juez]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez-Valera]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<source><![CDATA[Mol Microbiol]]></source>
<year>1995</year>
<volume>17</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>85-93</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Biological significance of a family of regularly spaced repeats in the genomes of Archaea, Bacteria and mitochondri]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mojica]]></surname>
<given-names><![CDATA[FJ]]></given-names>
</name>
<name>
<surname><![CDATA[Díez-Villaseñor]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Soria]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Juez]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Mol Microbiol]]></source>
<year>2000</year>
<volume>36</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>244-6</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mojica]]></surname>
<given-names><![CDATA[FJ]]></given-names>
</name>
<name>
<surname><![CDATA[Díez-Villaseñor]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[García-Martínez]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Soria]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[J Mol Evol]]></source>
<year>2005</year>
<volume>60</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>174-82</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[CRISPR/Cas, the Immune System of Bacteria and Archaea]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Horvath]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Barrangou]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Science]]></source>
<year>2010</year>
<volume>327</volume>
<page-range>167-70</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[CRISPR interference RNA-directed adaptive immunity in bacteria and archaea]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marraffini]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
<name>
<surname><![CDATA[Sontheimer]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat Rev Genet]]></source>
<year>2010</year>
<volume>11</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>181-90</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jinek]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Chylinski]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Fonfara]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Hauer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Doudna]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Charpentier]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Science]]></source>
<year>2012</year>
<volume>337</volume>
<numero>6096</numero>
<issue>6096</issue>
<page-range>816-21</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Inactivation of Cancer Mutations Utilizing CRISPR/Cas9]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gebler]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Lohoff]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Paszkowski-Rogacz]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mircetic]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Chakraborty]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Camgoz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Hamann]]></surname>
<given-names><![CDATA[MV]]></given-names>
</name>
</person-group>
<source><![CDATA[J Natl Cancer Inst]]></source>
<year>2016</year>
<volume>109</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>djw183</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Chinese scientists to pioneer first human CRISPR trial]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cyranosky]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>2016</year>
<volume>535</volume>
<page-range>476-7</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="book">
<collab>National Academies of Sciences Engineering and Medicine</collab>
<source><![CDATA[International Summit on Human Gene Editing: A Global Discussion]]></source>
<year>2016</year>
<publisher-loc><![CDATA[Washington, DC ]]></publisher-loc>
<publisher-name><![CDATA[The National Academies Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[CRISPR-Cas9 A European position on genome editing]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hirsch]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Lévy]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Chneiweiss]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>2017</year>
<volume>541</volume>
<numero>7635</numero>
<issue>7635</issue>
<page-range>30</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
