<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1657-9534</journal-id>
<journal-title><![CDATA[Colombia Médica]]></journal-title>
<abbrev-journal-title><![CDATA[Colomb. Med.]]></abbrev-journal-title>
<issn>1657-9534</issn>
<publisher>
<publisher-name><![CDATA[Universidad del Valle]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1657-95342020000200002</article-id>
<article-id pub-id-type="doi">10.25100/cm.v51i2.4279</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Drug Repositioning for COVID-19]]></article-title>
<article-title xml:lang="es"><![CDATA[Reposicionamiento de medicamentos para COVID-19]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Benavides-Cordoba]]></surname>
<given-names><![CDATA[Vicente]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad del Valle Facultad de Salud Escuela de Ciencias Básicas]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<volume>51</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S1657-95342020000200002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S1657-95342020000200002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S1657-95342020000200002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Drug repositioning is a strategy that identifies new uses of approved drugs to treat conditions different from their original purpose. With the advance of COVID-19 and the pandemic declaration; It has become the closest alternative to reduce the advance of the virus. Antimalarial, antiviral drugs, antibiotics, glucocorticoids, monoclonal antibodies, among others, are being studied; their findings, although preliminary, could establish a starting point in the search for a solution. In this review, we present a selection of drugs, of different classes and with potential activity against COVID-19, whose trials are ongoing; and as proofs of concept, double blind, add-on event-driven, would allow proposing research that generates results in less time and preserving quality criteria for drug development and approval by regulatory agencies.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El drug repositioning, es una estrategia que identifica nuevos usos de medicamentos aprobados, para tratar condiciones diferentes a las de su propósito original. Con el avance del COVID-19 y la declaración de pandemia; se ha convertido en la alternativa más cercana para frenar el avance del virus. Fármacos antimalariales, antivirales, antibióticos, glucocorticoides, anticuerpos monoclonales entre otros están siendo estudiados; sus hallazgos, aunque preliminares, podrían establecer un punto de partida en la búsqueda de la solución. En este artículo, se presenta una selección de fármacos, de distinta clase y con potencial actividad para combatir al COVID-19, cuyos ensayos se encuentran en curso; y como las prueba de concepto, double blind, add-on event-driven, permitirían proponer investigaciones que generen resultados en menor tiempo y conservando los criterios de calidad para el desarrollo de medicamentos y su aprobación por las agencias reguladoras.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[drug repositioning]]></kwd>
<kwd lng="en"><![CDATA[pandemics]]></kwd>
<kwd lng="en"><![CDATA[drug]]></kwd>
<kwd lng="en"><![CDATA[Therapeutic alternatives]]></kwd>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[Reposicionamiento de medicamentos]]></kwd>
<kwd lng="es"><![CDATA[Pandemia]]></kwd>
<kwd lng="es"><![CDATA[medicamentos]]></kwd>
<kwd lng="es"><![CDATA[Alternativas terapéuticas]]></kwd>
</kwd-group>
</article-meta>
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