<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1692-7273</journal-id>
<journal-title><![CDATA[Revista Ciencias de la Salud]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Cienc. Salud]]></abbrev-journal-title>
<issn>1692-7273</issn>
<publisher>
<publisher-name><![CDATA[Editorial Universidad del Rosario]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1692-72732022000300009</article-id>
<article-id pub-id-type="doi">10.12804/revistas.urosario.edu.co/revsalud/a.10216</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Colágeno tipo I en el agrandamiento gingival inducido por tratamiento ortodóntico: un estudio inmunohistoquímico piloto]]></article-title>
<article-title xml:lang="en"><![CDATA[Type I Collagen in Gingival Overgrowth Induced by Orthodontic Treatment: A Pilot Immunohistochemical Study]]></article-title>
<article-title xml:lang="pt"><![CDATA[Colágeno do tipo I no aumento gengival induzido por tratamento ortodôntico: um estudo imuno-histoquímico piloto]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Simancas-Escorcia]]></surname>
<given-names><![CDATA[Víctor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Harris-Ricardo]]></surname>
<given-names><![CDATA[Jonathan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Caballero]]></surname>
<given-names><![CDATA[Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Corporación Universitaria Rafael Núñez Grupo de investigación en salud CURN (GISACC), Programa de Odontología]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Cartagena Grupo de investigaciones GITOUC Facultad de Odontología]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<volume>20</volume>
<numero>3</numero>
<fpage>1</fpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S1692-72732022000300009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S1692-72732022000300009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S1692-72732022000300009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  el tratamiento ortodóntico es responsable del agrandamiento gingival (AG), una condición clínica caracterizada por el crecimiento patológico, difuso o localizado del tejido gingival. La acumulación excesiva de la matriz extracelular (MEC), incluyendo el colágeno tipo I, parece contribuir a las manifestaciones patológicas del AG. El objetivo del artículo es identificar y describir la distribución del colágeno tipo I en el tejido gingival de pacientes con AG por ortodoncia fija.  Materiales y métodos:  estudio de tipo descriptivo que analizó los tejidos gingivales de sujetos diagnosticados con AG portadores de ortodoncia (test, n=5) e individuos periodontalmente sanos (control, n=5). Las muestras se obtuvieron mediante gingivectomía. Todas las biopsias fueron fijadas, incluidas en parafina, cortadas y analizadas por medio de la coloración rojo picrosirius/verde rápido, con el propósito de distinguir las fibras de colágeno. Mediante una reacción inmunohistoquímica, el colágeno tipo I fue identificado con anticuerpo monoclonal.  Resultados:  en los pacientes con AG por tratamiento ortodóntico, se identificó un tejido epitelial hiperplásico con aumento evidente de las prolongaciones epiteliales y un tejido conectivo con abundantes haces de fibras de colágenos, principalmente en la lámina basal y la zona subyacente. Las fibras de colágeno tipo I en los tejidos de pacientes con AG por ortodoncia fueron gruesas de aspecto desorganizado, con una tinción inmunohistoquímica intensa, en comparación con las fibras del grupo control.  Conclusiones:  el aumento de fibras de colágenos, en especial de colágeno de tipo I, es un hallazgo histológico que caracteriza a los pacientes con AG por ortodoncia fija.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  Orthodontic treatment is responsible for gingival overgrowth (GO), a clinical condition characterized by pathological, diffuse, or localized growth of gingival tissue. Excessive accumulation of the extracellular matrix, including type I collagen, contributes to the pathological manifestations of GO. The objective of this study is to identify and describe the distribution of type I collagen in the gingival tissue of patients with GO because of fixed orthodontics.  Materials and Methods:  A descriptive study that analyzed the gingival tissues of subjects diagnosed with GO with orthodontic (test, n = 5) and periodontally healthy individuals (control, n = 5). The samples were obtained by gingivectomy. All the biopsies were fixed, embedded in paraffin, and cut and analyzed using picrosirius red/fast green staining, in order to distinguish the collagen fiber. By means of an immunohistochemical reaction, type I collagen was identified with a monoclonal antibody.  Results:  A hyperplastic epithelial tissue was identified with an evident increase in epithelial processes and connective tissue with abundant bundles of collagen fiber, mainly in the basal lamina and the underlying area in patients with GO because of orthodontic treatment. Type I collagen fiber in the tissues of patients with orthodontic GO were thick and disorganized in appearance with intense immunohistochemical staining, compared to the fibers of the control group.  Conclusions:  The increase in collagen fibers, particularly type I collagen, is a histological finding that characterizes patients with GO because of fixed orthodontics.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Introdução:  o tratamento ortodôntico é responsável pelo aumento gengival (AG), uma condição clínica caracterizada pelo crescimento patológico difuso ou localizado do tecido gengival. O acúmulo excessivo de matriz extracelular (MEC), incluindo colágeno tipo I, parece contribuir para as manifestações patológicas do AG. O objetivo deste trabalho é identificar e descrever a distribuição do colágeno do tipo I no tecido gengival de pacientes com AG devido à ortodontia fixa.  Materiais e métodos:  estudo descritivo que analisou os tecidos gengivais de indivíduos diagnosticados com AG em uso de ortodontia (teste, n = 5) e indivíduos periodontalmente saudáveis (controle, n = 5). As amostras foram obtidas por gengivectomia. Todas as biópsias foram fixadas, embebidas em parafina, cortadas e analisadas com coloração picrosirius vermelho/verde rápido, a fim de distinguir as fibras colágenas. Usando uma reação imuno-histoquímica, o colágeno tipo I foi identificado com anticorpo monoclonal.  Resultados:  em pacientes com AG devido ao tratamento ortodôntico, foi identificado tecido epitelial hiperplásico com evidente aumento das extensões epiteliais e tecido conjuntivo com abundantes feixes de fibras colágenas, principalmente na lâmina basal e região subjacente. As fibras de colágeno tipo I em tecidos de pacientes com AG ortodôntico eram espessas com aspecto desorganizado e intensa coloração imuno-histoquímica, em comparação com as fibras do grupo controle.  Conclusões:  o aumento das fibras colágenas, principalmente do colágeno do tipo I, é um achado histológico que caracteriza os pacientes com AG devido à ortodontia fixa.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[sobrecrecimiento gingival]]></kwd>
<kwd lng="es"><![CDATA[ortodoncia]]></kwd>
<kwd lng="es"><![CDATA[colágeno]]></kwd>
<kwd lng="es"><![CDATA[encía]]></kwd>
<kwd lng="es"><![CDATA[histología]]></kwd>
<kwd lng="en"><![CDATA[Gingival overgrowth]]></kwd>
<kwd lng="en"><![CDATA[orthodontics]]></kwd>
<kwd lng="en"><![CDATA[collagen]]></kwd>
<kwd lng="en"><![CDATA[gingiva]]></kwd>
<kwd lng="en"><![CDATA[histology]]></kwd>
<kwd lng="pt"><![CDATA[supercrescimento gengival]]></kwd>
<kwd lng="pt"><![CDATA[ortodontia]]></kwd>
<kwd lng="pt"><![CDATA[colágeno]]></kwd>
<kwd lng="pt"><![CDATA[gengiva]]></kwd>
<kwd lng="pt"><![CDATA[histologia]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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