<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1794-1237</journal-id>
<journal-title><![CDATA[Revista EIA]]></journal-title>
<abbrev-journal-title><![CDATA[Rev.EIA.Esc.Ing.Antioq]]></abbrev-journal-title>
<issn>1794-1237</issn>
<publisher>
<publisher-name><![CDATA[Escuela de ingenieria de Antioquia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1794-12372021000100220</article-id>
<article-id pub-id-type="doi">10.24050/reia.v18i35.1417</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Simulación del proceso de producción de L-fenilalanina por la ruta fermentativa utilizando el simulador SuperPro Designer®]]></article-title>
<article-title xml:lang="en"><![CDATA[Simulation of the L-phenylalanine production process by the fermentative route using SuperPro Designer® simulator]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[PÉREZ-SÁNCHEZ]]></surname>
<given-names><![CDATA[AMAURY]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[RANERO-GONZÁLEZ]]></surname>
<given-names><![CDATA[ELIZABETH]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[PÉREZ-SÁNCHEZ]]></surname>
<given-names><![CDATA[EDDY J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[SEGURA-SILVA]]></surname>
<given-names><![CDATA[RUTDALI MARIA]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Camagüey Departamento de Ingeniería Química Facultad de Ciencias Aplicadas]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Empresa Servicios Automotores S.A Dirección Comercial ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro de Ingeniería Genética y Biotecnología de Camagüey Departamento de Investigación y Desarrollo ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>18</volume>
<numero>35</numero>
<fpage>220</fpage>
<lpage>234</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S1794-12372021000100220&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S1794-12372021000100220&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S1794-12372021000100220&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La L-fenilalanina (L-Fe) es uno de los ocho aminoácidos esenciales para el cuerpo humano. En el presente trabajo se efectuó la simulación del proceso de producción de la L-Fe por la ruta fermentativa mediante el simulador SuperPro Designer®, con el fin de conocer sus indicadores de rentabilidad más importantes bajo las condiciones económicas actuales de Cuba. También se efectuó un estudio de sensibilidad con el objetivo de saber a partir de qué valor del parámetro precio de venta unitario del frasco de L-Fe se comienza a obtener un valor positivo del indicador Valor Actual Neto (VAN). Se obtuvo un margen bruto de 70,15 %, un costo unitario de producción de USD $ 66,75 por frasco y un retorno de la inversión de 38,92 %. A partir de un valor del precio de venta unitario del frasco de L-Fe de USD $ 115,3 empieza a ser rentable la planta de producción. El proceso de producción de L-Fe puede considerarse de rentable y factible desde el punto de vista técnico-económico atendiendo a los resultados obtenidos de VAN (USD $ 14 040 000), Tasa Interna de Retorno (49,14 %) y Período de Recuperación de la Inversión (2,57 años).]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract L-phenylalanine (L-Phe) is one of the eight essential amino acids for the human body. In this work, the simulation of the L-Phe fermentative production process was carried out using the SuperPro Designer® simulator, in order to know its most important profitability indicators under the current economic conditions in Cuba. A sensitivity study was also accomplished with the objective of knowing from which value of the parameter unit selling price of an L-Phe bottle a positive value begins to be obtained of the indicator Net Present Value (NPV). A gross margin of 70.15%, a unit cost of production of USD $ 66.75 per bottle and a return on investment of 38.92% were obtained. From a value of the unit sale price of the L-Phe bottle of USD $ 115.3 the production plant starts to be profitable. The L-Phe production process can be considered profitable and feasible from the techno-economical point of view, based on the results obtained of NPV (USD $ 14,040,000), Internal Rate of Return (49.14%) and Payback Time (2.57 years).]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Estudio de sensibilidad]]></kwd>
<kwd lng="es"><![CDATA[L-Fenilalanina]]></kwd>
<kwd lng="es"><![CDATA[Fermentación]]></kwd>
<kwd lng="es"><![CDATA[Rentabilidad]]></kwd>
<kwd lng="es"><![CDATA[Simulación]]></kwd>
<kwd lng="es"><![CDATA[SuperPro Designer ®]]></kwd>
<kwd lng="en"><![CDATA[Sensitivity study]]></kwd>
<kwd lng="en"><![CDATA[L-Phenylalanine]]></kwd>
<kwd lng="en"><![CDATA[Fermentation, Profitability]]></kwd>
<kwd lng="en"><![CDATA[Simulation]]></kwd>
<kwd lng="en"><![CDATA[SuperPro Designer ®]]></kwd>
</kwd-group>
</article-meta>
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