<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1900-9607</journal-id>
<journal-title><![CDATA[CES Medicina Veterinaria y Zootecnia]]></journal-title>
<abbrev-journal-title><![CDATA[Ces. Med. Vet. Zootec.]]></abbrev-journal-title>
<issn>1900-9607</issn>
<publisher>
<publisher-name><![CDATA[Universidad CES]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1900-96072018000200157</article-id>
<article-id pub-id-type="doi">10.21615/cesmvz.13.2.5</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Acetogeninas, alternativa en el tratamiento de cáncer en caninos]]></article-title>
<article-title xml:lang="en"><![CDATA[Acetogenins, alternative cancer treatment in dogs]]></article-title>
<article-title xml:lang="pt"><![CDATA[Acetogeninas, alternativa no tratamento de câncer em caninos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gaviria Calle]]></surname>
<given-names><![CDATA[Mónica Marcela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Posada Arias]]></surname>
<given-names><![CDATA[Silvia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mira Hernández]]></surname>
<given-names><![CDATA[Juliana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Corporación Universitaria Lasallista  ]]></institution>
<addr-line><![CDATA[Caldas ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Corporación Universitaria Lasallista  ]]></institution>
<addr-line><![CDATA[Caldas ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2018</year>
</pub-date>
<volume>13</volume>
<numero>2</numero>
<fpage>157</fpage>
<lpage>172</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S1900-96072018000200157&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S1900-96072018000200157&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S1900-96072018000200157&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El cáncer es una enfermedad que implica la alteración de procesos celulares, como metabolismo celular, activación o silenciamiento de genes y crecimiento descontrolado. Es una las principales causas de muerte en humanos, así como en animales de compañía, por lo cual cada vez es más importante la búsqueda y desarrollo de medicamentos. Algunos de los medicamentos que se producen para tratar el cáncer, provienen de plantas, como el taxol y la vincristina. La necesidad de ampliar el uso de productos naturales para tratar esta enfermedad, no solo en humanos sino en animales de compañía como caninos, abre las puertas a la búsqueda de actividad biológica de plantas que son usadas popularmente por presentar algún efecto con la enfermedad. Este es el caso de la guanábana (Annona muricata), de la cual se han extraído metabolitos secundarios (acetogeninas) que presentan in vitro mayor toxicidad en líneas celulares cancerígenas comparadas con líneas celulares normales. El fin de esta revisión fue realizar una aproximación de los usos de estos metabolitos en cáncer, para ello fue hecha una búsqueda en PubMed con diferentes palabras claves y se concluyó, que las acetogeninas comprenden una fuente potencial para el desarrollo de medicamentos contra el cáncer.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Cancer is a disease that alter cellular processes, like cell metabolism, activation and deactivation of genes and uncontrolled growth. It is one of the main causes of death in humans, as well as in companion animals, which is why it is increasingly important to seek and develop medicines for the treatment. Some of the drugs that are produced to treat cancer come from plants, such as taxol and vincristine. The necessity to expand the use of natural products to treat this disease, not only in humans but also in companion animals such as dogs, opens the doors to seek biological activity of plants that are commonly used because they present some effect over the disease. This is the case of soursop (Annona muricata), from which secondary metabolites (acetogenins) have been extracted and have presented in vitro greater toxicity in cancer cell lines compared to normal cell lines. Therefore, this review was carried out in order to make an approximation of the uses of these metabolites in cancer, for which a search was carried out in PubMed with different key words and it was concluded that acetogenins comprise a potential source for the development of medicines against cancer.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo O câncer é uma doença que envolve a alteração de processos celulares, como o metabolismo celular, ativação ou silenciamento de genes e o crescimento descontrolado. É uma das principais causas de morte em humanos, assim como em animais de companhia, para os quais a busca e o desenvolvimento de medicamentos são cada vez mais importantes. Algumas das drogas que são produzidas para tratar o câncer são derivadas de plantas, como o taxol e a vincristina. A necessidade de ampliar o uso de produtos naturais para tratar esta doença, não somente em humanos, mas em animais de companhia, como cães, abre as portas para a busca da atividade biológica de plantas que são popularmente usadas para causar algum efeito na doença. Este é o caso da graviola (Annona muricata), da qual se extraíram os metabólitos secundários (acetogeninas), que apresentam maior toxicidade in vitro nas linhagens de células cancerígenas do que nas linhagens normais. O objetivo desta revisão foi fazer uma aproximação dos usos desses metabólitos no câncer, para os quais foi feita uma pesquisa em PubMed com palavras-chave diferentes e concluiu-se que as acetogeninas constituem uma fonte potencial para o desenvolvimento de drogas anti-câncer.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Acetogenins]]></kwd>
<kwd lng="en"><![CDATA[cancer]]></kwd>
<kwd lng="en"><![CDATA[canine]]></kwd>
<kwd lng="en"><![CDATA[ACGs]]></kwd>
<kwd lng="es"><![CDATA[Acetogeninas]]></kwd>
<kwd lng="es"><![CDATA[cáncer]]></kwd>
<kwd lng="es"><![CDATA[caninos]]></kwd>
<kwd lng="es"><![CDATA[ACGs]]></kwd>
<kwd lng="pt"><![CDATA[Acetogeninas]]></kwd>
<kwd lng="pt"><![CDATA[cães]]></kwd>
<kwd lng="pt"><![CDATA[câncer]]></kwd>
<kwd lng="pt"><![CDATA[ACGs]]></kwd>
</kwd-group>
</article-meta>
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