<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2011-0839</journal-id>
<journal-title><![CDATA[Universitas Medica]]></journal-title>
<abbrev-journal-title><![CDATA[Univ. Med.]]></abbrev-journal-title>
<issn>2011-0839</issn>
<publisher>
<publisher-name><![CDATA[Pontificia Universidad Javeriana]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2011-08392021000400002</article-id>
<article-id pub-id-type="doi">10.11144/javeriana.umed62-4.tibo</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Tibolone Effectiveness and Incidence of Adverse Effects in Postmenopausal Women. Quasi Experimental Study in Armenia, Colombia, 2012-2015]]></article-title>
<article-title xml:lang="es"><![CDATA[Efectividad de la tibolona e incidencia de efectos adversos en mujeres posmenopáusicas. Estudio cuasiexperimental en Armenia (Colombia), 2012-2015]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Espitia De La Hoz]]></surname>
<given-names><![CDATA[Franklin José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Alcalá de Henares  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>62</volume>
<numero>4</numero>
<fpage>3</fpage>
<lpage>14</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S2011-08392021000400002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S2011-08392021000400002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S2011-08392021000400002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective: To establish the effectiveness of tibolone in menopausal symptoms and sexual function, as well as the incidence of adverse effects, in postmenopausal women.  Material and methods: Quasi-experimental study, before-after; in 127 postmenopausal women older than 40 years, with climacteric symptoms and last menstrual period at least 2 years before entering the study, with a stable partner. In a private university clinic in Armenia (Quindío), Colombia, between 2012 and 2015. The Quality of Life Scale Menopause Rating Scale (MRS) and the Female Sexual Function Index (IFSF) were used as instruments. Simple random sampling was done. The Stata® 16.1 program was used.  Results: The average age was 56.91 ± 7.34 years. At the end of the study, an improvement in menopausal symptoms of 94.48% (. &lt; 0.05) was achieved, with a decrease in the MRS score from 15.91 ± 3.21 to 6.18 ± 3, 75 points (. &lt; 0.05). Sexual dysfunctions reported an improvement of 86.56%; the IFSF went from 23.19 ± 6.41 points to 28.02 ± 6.63 (. &lt; 0.05). Adverse effects were present from the first 3 months of initiation of therapy, the most frequent being: amenorrhea (85.82%), mastalgia (18.89%), and edema (17.32%).  Conclusions: Tibolone has a positive effectiveness in the treatment of the symptoms of menopause, reducing both the amount and the severity of the same; associated with a clear improvement in sexual function, with mild, tolerable and transitory adverse effects.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo: Establecer la efectividad de la tibolona en la sintomatología menopáusica y la función sexual, así como la incidencia de efectos adversos en mujeres posmenopáusicas.  Material y métodos: Estudio cuasiexperimental, antes-después, en una clínica privada de carácter universitario en Armenia (Quindío, Colombia), entre 2012 y 2015, en 127 mujeres posmenopáusicas mayores de 40 años, con síntomas climatéricos y último periodo menstrual al menos 2 años antes de ingresar al estudio, con pareja estable. Se utilizaron como instrumentos la escala de calidad de vida Menopause Rating Scale .MRS) y el Índice de Función Sexual Femenino (IFSF). Se hizo un muestreo aleatorio simple. Se utilizó el programa Stata. 16.1.  Resultados: La edad promedio fue de 56,91 ± 7,34 años. Al final del estudio se alcanzó una mejoría de la sintomatología menopáusica del 94,48 % (. &lt; 0,05), con una disminución en la puntuación de la escala MRS de 15,91 ± 3,21 a 6,18 ± 3,75 puntos (. &lt; 0,05). Las disfunciones sexuales reportaron una mejoría del 86,56 %; el IFSF pasó de 23,19 ± 6,41 puntos a 28,02 ± 6,63 (. &lt; 0,05). Los efectos adversos se hicieron presentes desde los primeros 3 meses de inicio de la terapia, entre ellos amenorrea (85,82 %), mastalgia (18,89 %) y edema (17,32 %).  Conclusiones: La tibolona tiene una positiva efectividad en el tratamiento de la sintomatología de la menopausia, al reducir tanto la cantidad como su severidad; además, se asocia a una franca mejoría de la función sexual, con efectos adversos leves, tolerables y transitorios.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[women]]></kwd>
<kwd lng="en"><![CDATA[postmenopause]]></kwd>
<kwd lng="en"><![CDATA[signs and symptoms]]></kwd>
<kwd lng="en"><![CDATA[hormone replacement therapy]]></kwd>
<kwd lng="en"><![CDATA[adverse effects]]></kwd>
<kwd lng="en"><![CDATA[incidence]]></kwd>
<kwd lng="es"><![CDATA[mujeres]]></kwd>
<kwd lng="es"><![CDATA[posmenopausia]]></kwd>
<kwd lng="es"><![CDATA[signos y síntomas]]></kwd>
<kwd lng="es"><![CDATA[terapia de remplazo de hormonas]]></kwd>
<kwd lng="es"><![CDATA[efectos adversos]]></kwd>
<kwd lng="es"><![CDATA[incidencia]]></kwd>
</kwd-group>
</article-meta>
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