<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2011-0839</journal-id>
<journal-title><![CDATA[Universitas Medica]]></journal-title>
<abbrev-journal-title><![CDATA[Univ. Med.]]></abbrev-journal-title>
<issn>2011-0839</issn>
<publisher>
<publisher-name><![CDATA[Pontificia Universidad Javeriana]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2011-08392022000100015</article-id>
<article-id pub-id-type="doi">10.11144/javeriana.umed63-1.bron</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Bronquiolitis constrictiva en el lactante postinfección por SARS-CoV-2]]></article-title>
<article-title xml:lang="en"><![CDATA[Post Infection Constrictive Bronchiolitis in an Infant after SARS-CoV-2]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garcíaa]]></surname>
<given-names><![CDATA[María Isabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[Laura Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Panqueva]]></surname>
<given-names><![CDATA[Olga Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Restrepo]]></surname>
<given-names><![CDATA[Sonia María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Uriza]]></surname>
<given-names><![CDATA[Luis Felipe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Pontificia Universidad Javeriana Hospital Universitario San Ignacio ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Pontificia Universidad Javeriana Hospital Universitario San Ignacio ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Pontificia Universidad Javeriana Hospital Universitario San Ignacio ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Pontificia Universidad Javeriana Hospital Universitario San Ignacio ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Pontificia Universidad Javeriana Hospital Universitario San Ignacio ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<volume>63</volume>
<numero>1</numero>
<fpage>148</fpage>
<lpage>154</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S2011-08392022000100015&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S2011-08392022000100015&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S2011-08392022000100015&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La bronquiolitis obliterante es una enfermedad crónica pulmonar e irreversible que lleva a obstrucción y obliteración de las pequeñas vías aéreas y que puede presentarse por afectación peribronquiolar, desde el epitelio hacia la luz de forma concéntrica (constrictiva), o por ocupación del lumen del bronquiolo, dado por una proliferación del tejido endoluminal (proliferativa). La lesión de la vía aérea pequeña se puede presentar postrasplante pulmonar o de médula ósea, por infecciones, por inhalación de sustancias tóxicas, por enfermedades del tejido conectivo o secundaria a fármacos. En la población pediátrica, la forma constrictiva secundaria a infecciones severas de las vías respiratorias, y conocida como bronquiolitis obliterante postinfecciosa (PIBO), es la más común y su presentación clínica puede ser muy variable, desde una leve a una severa obstrucción de la vía aérea que no responde a tratamiento con broncodilatadores, además de hipoxemia, tos y taquipnea. El diagnóstico es difícil, dada la necesidad de una biopsia pulmonar, la ausencia en la actualidad de biomarcadores y porque no se entiende claramente su fisiopatología. La tomografía de tórax, así como un puntaje clínico, predice con alta precisión la bronquiolitis obliterante. El tratamiento está dirigido a suprimir la respuesta inflamatoria para evitar el daño pulmonar. El artículo presenta el caso de un lactante de dos meses de edad con antecedente en su periodo neonatal de infección respiratoria por SARS-CoV-2 (COVID-19), quien presenta cambios radiológicos y clínicos compatibles con PIBO.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Bronchiolitis obliterans is a chronic and irreversible pulmonary disease that leads to obstruction and obliteration of the small airways and that can present by peribronchiolar involvement, from the epithelium towards the lumen in a concentric (constrictive), or by occupation of the lumen of the bronchiole, given by proliferation of the endoluminal tissue (proliferative). The lesion at the level of the small airway can occur after lung or bone marrow transplantation, infections, inhalation of toxic substances, connective tissue diseases or secondary to drugs. In the pediatric population, the constrictive form secondary to severe respiratory tract infections, and known as post-infectious bronchiolitis obliterans (PIBO), is the most common and its clinical presentation can be highly variable from mild to severe airway obstruction that does not respond to treatment with bronchodilators, in addition to hypoxemia, cough and tachypnea. Diagnosis is difficult given the previous need for a lung biopsy, the current absence of biomarkers, and since its pathophysiology is not clearly understood. The CT as well as a clinical score predict with high precision the diagnosis of obliterative bronchiolitis. Treatment is aimed at suppressing the inflammatory response to prevent lung damage. We report a case of a 2-month-old infant with a history of respiratory infection due to SARS-CoV-2 (COVID-19) in his neonatal period is presented, in whom radiological and clinical changes compatible with PIBO were evidenced.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[bronquiolitis constrictiva]]></kwd>
<kwd lng="es"><![CDATA[infección por coronavirus]]></kwd>
<kwd lng="es"><![CDATA[lactante]]></kwd>
<kwd lng="es"><![CDATA[respuesta inmune]]></kwd>
<kwd lng="es"><![CDATA[inflamación]]></kwd>
<kwd lng="es"><![CDATA[enfermedad respiratoria]]></kwd>
<kwd lng="en"><![CDATA[constrictive bronchiolitis]]></kwd>
<kwd lng="en"><![CDATA[coronavirus infection]]></kwd>
<kwd lng="en"><![CDATA[infant]]></kwd>
<kwd lng="en"><![CDATA[immune response]]></kwd>
<kwd lng="en"><![CDATA[inflammation]]></kwd>
<kwd lng="en"><![CDATA[respiratory tract disease]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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