<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2500-5006</journal-id>
<journal-title><![CDATA[Revista Colombiana de Nefrología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colom. nefrol.]]></abbrev-journal-title>
<issn>2500-5006</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Nefrología e Hipertensión Arterial]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2500-50062023000300205</article-id>
<article-id pub-id-type="doi">10.22265/acnef.10.3.612</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Biochemical Approach of Acid-Base Disturbances]]></article-title>
<article-title xml:lang="es"><![CDATA[Abordaje bioquímico de alteraciones ácido-base]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Prado]]></surname>
<given-names><![CDATA[Alejandro Nitsch]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Institute DiabetCentro  ]]></institution>
<addr-line><![CDATA[Guatemala City ]]></addr-line>
<country>Guatemala</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>10</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S2500-50062023000300205&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S2500-50062023000300205&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S2500-50062023000300205&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  The current paradigms in arterial blood gas analysis are based on mathematical or physicochemical models that require complex algorithms for interpretation. This leads to avoidance or dislike from health care professionals.  Objectives:  To formulate a new approach to the analysis and classification of acid base disturbances.  Methodology:  We conducted a systematic review of the related literature and a paradigm shift for data interpretation.  Results:  Acid-base disorders can be grouped and managed according to the underlying biochemical processes.  Discussion and Conclusions:  This proposal represents a new classification, which groups acid base disorders according to the underlying causal biochemical process. Disorders with an elevated anion gap relate to alterations in cellular respiration (energy/ATP production)- All disturbances with normal anion gap relate to transmembrane ion exchange.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  los paradigmas actuales del análisis de gasometrías sanguíneas están basados en modelos matemáticos o físico químicos que requieren algoritmos complejos de interpretación. Esto conduce a que los profesionales de salud eviten y/o rechacen el tema.  Objetivo:  formular un nuevo abordaje para el análisis y clasificación de los trastornos ácido-base.  Metodología:  revisión sistemática de la literatura sobre el tema y cambio en el paradigma de interpretación de los datos.  Resultados:  los trastornos ácido-base pueden agruparse y manejarse de acuerdo con los procesos bioquímicos subyacentes  Discusión y conclusiones:  la nueva clasificación propuesta agrupa los trastornos ácido base según el proceso bioquímico subyacente. Los trastornos que elevan la brecha aniónica corresponden a alteraciones en la respiración celular (producción de energía/ATP). Los trastornos con brecha aniónica normal corresponden a alteraciones en el intercambio transmembrana de iones.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Acid-base equilibrium]]></kwd>
<kwd lng="en"><![CDATA[metabolic acidosis]]></kwd>
<kwd lng="en"><![CDATA[metabolic alkalosis]]></kwd>
<kwd lng="en"><![CDATA[respiratory acidosis]]></kwd>
<kwd lng="en"><![CDATA[respiratory alkalosis]]></kwd>
<kwd lng="en"><![CDATA[alkalemia]]></kwd>
<kwd lng="en"><![CDATA[acidemia]]></kwd>
<kwd lng="en"><![CDATA[alkalosis]]></kwd>
<kwd lng="en"><![CDATA[acidosis]]></kwd>
<kwd lng="en"><![CDATA[critical care]]></kwd>
<kwd lng="en"><![CDATA[blood gas analysis]]></kwd>
<kwd lng="en"><![CDATA[cellular respiration.]]></kwd>
<kwd lng="es"><![CDATA[equilibrio ácido-base]]></kwd>
<kwd lng="es"><![CDATA[acidosis metabólica]]></kwd>
<kwd lng="es"><![CDATA[alcalosis metabólica]]></kwd>
<kwd lng="es"><![CDATA[acidosis respiratoria]]></kwd>
<kwd lng="es"><![CDATA[alcalosis respiratoria]]></kwd>
<kwd lng="es"><![CDATA[alcalemia]]></kwd>
<kwd lng="es"><![CDATA[acidemia]]></kwd>
<kwd lng="es"><![CDATA[alcalosis]]></kwd>
<kwd lng="es"><![CDATA[acidosis]]></kwd>
<kwd lng="es"><![CDATA[cuidados críticos]]></kwd>
<kwd lng="es"><![CDATA[gasometría sanguínea]]></kwd>
<kwd lng="es"><![CDATA[respiración celular.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Berend]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diagnostic Use of Base Excess in Acid-Base Disorders]]></article-title>
<source><![CDATA[NEJM]]></source>
<year>2018</year>
<volume>378</volume>
<numero>15</numero>
<issue>15</issue>
<page-range>1419-28</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dzierba]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
<name>
<surname><![CDATA[Abraham]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A Practical Approach to Understanding Acid-Base Abnormalities in Critical illness]]></article-title>
<source><![CDATA[J Pharm Practice]]></source>
<year>2011</year>
<volume>24</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>17-26</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ahmad]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Wolberg]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kahwaji]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[Biochemistry, Electron Transport Chain]]></source>
<year>2021</year>
<publisher-name><![CDATA[StatPearls]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="">
<collab>Anesthesia Education Website</collab>
<source><![CDATA[Acid-base physiology]]></source>
<year>cite</year>
<month>d </month>
<day>20</day>
</nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="">
<collab>United states environmental Protection Agency</collab>
<source><![CDATA[Technical Overview of Volatile Organic Compounds]]></source>
<year>2021</year>
</nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kaufman]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
</person-group>
<source><![CDATA[Interpretation of ABgs]]></source>
<year>cite</year>
<month>d </month>
<day>20</day>
<publisher-name><![CDATA[American Thoracic Asociation]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saha]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bhattacharya]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Sharma]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
<name>
<surname><![CDATA[Chakraborty]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Probable Molecular Mechanism of Remdesivir for the Treatment of COVID-19: Need to Know More]]></article-title>
<source><![CDATA[J ARCMED]]></source>
<year>2020</year>
<volume>51</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>585-6</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Blough]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Moreland]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Mora]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metformin-induced lactic acidosis with emphasis on the anion gap]]></article-title>
<source><![CDATA[Proc (Bayl Univ Md Cent)]]></source>
<year>2015</year>
<volume>28</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>31-3</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Palmer]]></surname>
<given-names><![CDATA[BF]]></given-names>
</name>
<name>
<surname><![CDATA[Clegg]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Salicylate Toxicity]]></article-title>
<source><![CDATA[NEJM]]></source>
<year>2020</year>
<volume>382</volume>
<page-range>2544-55</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[DuBose]]></surname>
<given-names><![CDATA[TD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Therapy in Nephrology and Hypertension]]></article-title>
<source><![CDATA[Metabolic and respiratory acidosis]]></source>
<year>2008</year>
<page-range>368-80</page-range><publisher-name><![CDATA[Saunders Elsevier]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
