<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-0011</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[rev.fac.med.]]></abbrev-journal-title>
<issn>0120-0011</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional de Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-00112016000400671</article-id>
<article-id pub-id-type="doi">10.15446/revfacmed.v64n4.54489</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Revisión sistemática de estudios de costo-efectividad del test de portadores para fibrosis quística]]></article-title>
<article-title xml:lang="en"><![CDATA[Systematic review of studies on cost-effectiveness of cystic fibrosis carrier testing]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Andrade-Cerquera]]></surname>
<given-names><![CDATA[Ernesto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Rojas]]></surname>
<given-names><![CDATA[Jorge Augusto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Colombia Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Bogotá D.C]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Colombia Facultad de Ciencias ]]></institution>
<addr-line><![CDATA[Bogotá D.C]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<volume>64</volume>
<numero>4</numero>
<fpage>671</fpage>
<lpage>677</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-00112016000400671&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-00112016000400671&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-00112016000400671&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción. La fibrosis quística es considerada la enfermedad autosómica con afecciones multisistémicas más común en población blanca no hispánica.  Objetivo. Revisar la evidencia disponible sobre costo-efectividad del test de portador para fibrosis quística en comparación con la no intervención.  Materiales y métodos. Se realizó una revisión sistemática de evaluación de costo-efectividad del test genético para portadores de fibrosis quística a través de las base de datos MEDLINE, Embase, NHS, EBM Reviews - Cochrane Database of Systematic Reviews, LILACS, Health Technology Assessment, Genetests.org, Genetsickkids.org y Web of Science. Fueron incluidos estudios de costo-efectividad sin restricción de lenguaje ni fecha de publicación.  Resultados. Solo 13 estudios fueron relevantes para su revisión completa. Se encontraron estrategias de tamizaje prenatal, preconcepcional y mixto. La perspectiva en salud fue la más usada; la tasa de descuento aplicada fue heterogénea entre 3.5% y 5%; la unidad de análisis principal fue el costo por pareja portadora detectada seguida de costo por nacimiento evitado con fibrosis quística. Se evidenció que la estrategia más costo-efectiva fue la del tamizaje preconcepcional asociada al test prenatal.  Conclusiones. Se encontró marcada heterogeneidad en la metodología aplicada, lo que llevo a que los resultados no fueran comparables y se concluyera que existen diferentes enfoques de este test genético.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Cystic fibrosis is considered the most common autosomal disease with multisystem complications in non-Hispanic white population.  Objective: To review the available evidence on cost-effectiveness of the cystic fibrosis carrier testing compared to no intervention.  Materials and methods: The databases of MEDLINE, Embase, NHS, EBM Reviews - Cochrane Database of Systematic Reviews, LILACS, Health Technology Assessment, Genetests.org, Genetsickkids.org and Web of Science were used to conduct a systematic review of the cost-effectiveness of performing the genetic test in cystic fibrosis patients. Cost-effectiveness studies were included without language or date of publication restrictions.  Results: Only 13 studies were relevant for full review. Prenatal, preconception and mixed screening strategies were found. Health perspective was the most used; the discount rate applied was heterogeneous between 3.5% and 5%; the main analysis unit was the cost per detected carrier couple, followed by cost per averted birth with cystic fibrosis. It was evident that the most cost- effective strategy was preconception screening associated with prenatal test.  Conclusions: A marked heterogeneity in the methodology was found, which led to incomparable results and to conclude that there are different approaches to this genetic test.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Fibrosis quística]]></kwd>
<kwd lng="es"><![CDATA[Revisión]]></kwd>
<kwd lng="es"><![CDATA[Evaluación de costo-efectividad (DeCS).]]></kwd>
<kwd lng="en"><![CDATA[Cystic Fibrosis]]></kwd>
<kwd lng="en"><![CDATA[Review]]></kwd>
<kwd lng="en"><![CDATA[Cost-Effectiveness Evaluation (MeSH).]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marín-Silva]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
</person-group>
<source><![CDATA[Determinación de la frecuencia de portadores de la mutación F508del en la población colombiana]]></source>
<year>2007</year>
<publisher-loc><![CDATA[Bogotá, D.C ]]></publisher-loc>
<publisher-name><![CDATA[Facultad de Medicina, Universidad del Rosario]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Fibrosis quística: la frontera del conocimiento molecular y sus aplicaciones clínicas]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Orozco]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Chávez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Saldaña]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Velázquez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Carnevale]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[González-del Ángel]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev. Invest. Clin]]></source>
<year>2006</year>
<volume>58</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>139-52</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Frecuencia de la mutación F508del en estudiantes de la Facultad de Medicina de la Universidad del Rosario, Bogotá, Colombia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mateus]]></surname>
<given-names><![CDATA[HE]]></given-names>
</name>
<name>
<surname><![CDATA[Fonseca]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[LS]]></given-names>
</name>
<name>
<surname><![CDATA[Peñaloza]]></surname>
<given-names><![CDATA[IF]]></given-names>
</name>
<name>
<surname><![CDATA[Forero]]></surname>
<given-names><![CDATA[DV]]></given-names>
</name>
<name>
<surname><![CDATA[Perdomo]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
</person-group>
<source><![CDATA[Colomb. Med]]></source>
<year>2007</year>
<volume>38</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>352-6</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Committee Opinion No 486: Update on carrier screening for cystic fibrosis]]></article-title>
<collab>American College of Obstetricians and Gynecologists</collab>
<source><![CDATA[Obstet Gynecol]]></source>
<year>2011</year>
<volume>117</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1028-31</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[PCRheteroduplex por agrupamiento: implementación de un método de identificación de portadores de la mutación más común causal de Fibrosis quística en Colombia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jay]]></surname>
<given-names><![CDATA[LM]]></given-names>
</name>
<name>
<surname><![CDATA[Mateus]]></surname>
<given-names><![CDATA[HE]]></given-names>
</name>
<name>
<surname><![CDATA[Fonseca]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
<name>
<surname><![CDATA[Restrepo]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[Keyeux]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Colomb. Med]]></source>
<year>2006</year>
<volume>37</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>176-82</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The cost-effectiveness of prenatal carrier screening for cystic fibrosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lieu]]></surname>
<given-names><![CDATA[TA]]></given-names>
</name>
<name>
<surname><![CDATA[Watson]]></surname>
<given-names><![CDATA[SE]]></given-names>
</name>
<name>
<surname><![CDATA[Washington]]></surname>
<given-names><![CDATA[AE]]></given-names>
</name>
</person-group>
<source><![CDATA[Obstet. Gynecol]]></source>
<year>1994</year>
<volume>84</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>903-12</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Carrier screening for cystic fibrosis: costs and clinical outcomes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Asch]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Hershey]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[DeKay]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pauly]]></surname>
<given-names><![CDATA[MV]]></given-names>
</name>
<name>
<surname><![CDATA[Patton]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<name>
<surname><![CDATA[Jedrziewski]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
</person-group>
<source><![CDATA[Med. Decis. Making]]></source>
<year>1998</year>
<volume>18</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>202-12</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cost comparison of different methods of screening for cystic fibrosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Morris]]></surname>
<given-names><![CDATA[JK]]></given-names>
</name>
<name>
<surname><![CDATA[Oppenheimer]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Med. Screen]]></source>
<year>1995</year>
<volume>2</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>22-7</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cost effectiveness of antenatal screening for cystic fibrosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cuckle]]></surname>
<given-names><![CDATA[HS]]></given-names>
</name>
<name>
<surname><![CDATA[Richardson]]></surname>
<given-names><![CDATA[GA]]></given-names>
</name>
<name>
<surname><![CDATA[Sheldon]]></surname>
<given-names><![CDATA[TA]]></given-names>
</name>
<name>
<surname><![CDATA[Quirke]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[BMJ]]></source>
<year>1995</year>
<volume>311</volume>
<numero>7018</numero>
<issue>7018</issue>
<page-range>1460-3</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cost effectiveness of DNA diagnosis for four monogenic diseases]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Van der Riet]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Van Hout]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Rutten]]></surname>
<given-names><![CDATA[FF]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Med. Genet]]></source>
<year>1997</year>
<volume>34</volume>
<page-range>741-5</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Costs, effects, and savings of screening for cystic fibrosis gene carriers]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wildhagen]]></surname>
<given-names><![CDATA[MF]]></given-names>
</name>
<name>
<surname><![CDATA[Hilderink]]></surname>
<given-names><![CDATA[HB]]></given-names>
</name>
<name>
<surname><![CDATA[Verzijl]]></surname>
<given-names><![CDATA[JG]]></given-names>
</name>
<name>
<surname><![CDATA[Verheij]]></surname>
<given-names><![CDATA[JB]]></given-names>
</name>
<name>
<surname><![CDATA[Kooij]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Tijmstra]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Epidemiol. Community Health]]></source>
<year>1998</year>
<volume>52</volume>
<numero>777</numero>
<issue>777</issue>
<page-range>459-67</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Prenatal screening for cystic fibrosis carriers: an economic evaluation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rowley]]></surname>
<given-names><![CDATA[PT]]></given-names>
</name>
<name>
<surname><![CDATA[Loader]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kaplan]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
</person-group>
<source><![CDATA[Am. J. Hum. Genet]]></source>
<year>1998</year>
<volume>63</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1160-74</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Prenatal cystic fibrosis screening in Mexican Americans: An economic analysis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Doyle]]></surname>
<given-names><![CDATA[NM]]></given-names>
</name>
<name>
<surname><![CDATA[Gardner]]></surname>
<given-names><![CDATA[MO]]></given-names>
</name>
</person-group>
<source><![CDATA[Am. J. Obstet. Gynecol]]></source>
<year>2003</year>
<volume>189</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>769-74</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cost-effectiveness of a school-based tay-sachs and cystic fibrosis genetic carrier screening program]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Warren]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Anderson]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Proos]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
<name>
<surname><![CDATA[Burnett]]></surname>
<given-names><![CDATA[LB]]></given-names>
</name>
<name>
<surname><![CDATA[Barlow-Stewart]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Hall]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Genet. Med]]></source>
<year>2005</year>
<volume>7</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>484-94</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Preconception cystic fibrosis carrier screening: costs and consequences]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Weijers-Poppelaars]]></surname>
<given-names><![CDATA[FA]]></given-names>
</name>
<name>
<surname><![CDATA[Wildhagen]]></surname>
<given-names><![CDATA[MF]]></given-names>
</name>
<name>
<surname><![CDATA[Henneman]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Cornel]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Kate]]></surname>
<given-names><![CDATA[LP]]></given-names>
</name>
</person-group>
<source><![CDATA[Genet. Test]]></source>
<year>2005</year>
<volume>9</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>158-66</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Is Cystic Fibrosis Carrier Screening Cost Effective?]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wei]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Quigg]]></surname>
<given-names><![CDATA[MH]]></given-names>
</name>
<name>
<surname><![CDATA[Monaghan]]></surname>
<given-names><![CDATA[KG]]></given-names>
</name>
</person-group>
<source><![CDATA[Community Genet]]></source>
<year>2007</year>
<volume>10</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>103-9</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Informing policy for the Australian context-Costs, outcomes and cost savings of prenatal carrier screening for cystic fibrosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Maxwell]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Brameld]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Youngs]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Geelhoed]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[O&#8217;leary]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Aust. N. Z. J. Obstet. Gynaecol]]></source>
<year>2010</year>
<volume>50</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>51-9</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cost-effectiveness of carrier screening for cystic fibrosis in Australia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Norman]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Van Gool]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Hall]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Delatycki]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Massie]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Cyst. Fibros]]></source>
<year>2012</year>
<volume>11</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>281-7</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Economic evaluation of cystic fibrosis screening: a review of the literature]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Radhakrishnan]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[van Gool]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Hall]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Delatycki]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Massie]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Health Policy]]></source>
<year>2008</year>
<volume>85</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>133-47</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[CFTR mutations in three Latin American countries]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Restrepo]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[Pineda]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Rojas-Martínez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Gutiérrez]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Morales]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[Am. J. Med. Genet]]></source>
<year>2000</year>
<volume>91</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>277-9</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Fibrosis Quística en Colombia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vásquez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Aristizával]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Daza]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev. Chil. Neumol. Ped]]></source>
<year>2010</year>
<volume>5</volume>
<page-range>44-50</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
