<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-4157</journal-id>
<journal-title><![CDATA[Biomédica]]></journal-title>
<abbrev-journal-title><![CDATA[Biomed.]]></abbrev-journal-title>
<issn>0120-4157</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-41572025000100080</article-id>
<article-id pub-id-type="doi">10.7705/biomedica.7315</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Características clínicas, histopatológicas e inmunohistoquímicas de pacientes con síndrome seco y biopsia de glándula salival con puntaje de foco de 1 o más]]></article-title>
<article-title xml:lang="en"><![CDATA[Clinical, histopathological, and immunohistochemical characteristics of patients with sicca syndrome with a focus score &#8805; 1 in the minor salivary gland biopsy]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lamos-Duarte]]></surname>
<given-names><![CDATA[Andrés Felipe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Parra-Medina]]></surname>
<given-names><![CDATA[Rafael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rivadeneira-Chamorro]]></surname>
<given-names><![CDATA[Carlos Santiago]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castañeda-González]]></surname>
<given-names><![CDATA[Juan Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Escobar]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas-Villarraga]]></surname>
<given-names><![CDATA[Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Vargas]]></surname>
<given-names><![CDATA[Gabriel Santiago]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arredondo]]></surname>
<given-names><![CDATA[Ana María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cubides]]></surname>
<given-names><![CDATA[Héctor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Polo]]></surname>
<given-names><![CDATA[José Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Capasso]]></surname>
<given-names><![CDATA[Juan José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ibáñez]]></surname>
<given-names><![CDATA[Claudia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cajamarca-Barón]]></surname>
<given-names><![CDATA[Jairo Hernán]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Fundación Universitaria de Ciencias de la Salud - FUCS Hospital de San José ]]></institution>
<addr-line><![CDATA[Bogotá, D. C. ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Cancerología Fundación Universitaria de Ciencias de la Salud - FUCS ]]></institution>
<addr-line><![CDATA[Bogotá, D. C. ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Fundación Universitaria de Ciencias de la Salud - FUCS  ]]></institution>
<addr-line><![CDATA[Bogotá, D. C. ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Biomab I.P.S.  ]]></institution>
<addr-line><![CDATA[Bogotá, D. C. ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Hospital Infantil Universitario de San José Fundación Universitaria de Ciencias de la Salud - FUCS ]]></institution>
<addr-line><![CDATA[Bogotá, D. C. ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Hospital de San José Fundación Universitaria de Ciencias de la Salud - FUCS ]]></institution>
<addr-line><![CDATA[Bogotá D. C. ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2025</year>
</pub-date>
<volume>45</volume>
<numero>1</numero>
<fpage>80</fpage>
<lpage>94</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-41572025000100080&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-41572025000100080&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-41572025000100080&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción.  El síndrome de Sjögren es una enfermedad autoinmunitaria sistémica. Se ha descrito la utilidad de la inmunohistoquímica de la biopsia de glándula salival menor por su utilidad en la caracterización del fenotipo de los linfocitos en los casos de difícil diagnóstico.  Objetivo.  Describir las variables sociodemográficas, clínicas, serológicas, histopatológicas e inmunohistoquímicas de los pacientes con síndrome seco en quienes se practicó biopsia de glándula salival menor que resultó con un puntaje de foco de uno o más.  Materiales y métodos.  Se adelantó un estudio observacional, retrospectivo, en el que se incluyeron pacientes en estudio por posible síndrome seco y cuya biopsia de glándula salival menor estaba disponible y había obtenido un puntaje de foco de uno o más. En la biopsia de la glándula salival menor se realizó inmunohistoquímica con cromógeno rojo para la identificación de los linfocitos T CD8 positivos y marrón, para los linfocitos T CD4 positivos. Se determinó la relación de los marcadores CD20:CD3 y CD4:CD8 con el equipo MoticEasyScan Pro-6&#8482; (MOTIC) y el software QuPath&#8482;. El análisis de las variables cualitativas se realizó mediante la aplicación de la prueba de ji al cuadrado (c2) o la prueba exacta de Fisher; para el de las variables cuantitativas, la prueba seleccionó según el supuesto de normalidad.  Resultados.  Se analizaron 28 pacientes, 16 con síndrome de Sjögren y 8 con poliautoinmunidad. Se encontró una asociación entre la presencia de atrofia glandular en la biopsia de glándula salival menor y el desarrollo de poliautoinmunidad (OR = 11,1; IC 95%: 1,12-112; p = 0,033). Las relaciones CD20:CD3 y CD4:CD8 fueron normales, sin diferencias estadísticamente significativas entre pacientes con síndrome de Sjögren y sin él. En el subgrupo de pacientes con síndrome de Sjögren hubo predominancia de los linfocitos T CD4, 15 de los 16 casos tenían una relación CD4:CD8 igual o mayor de 2:1.  Conclusiones.  Se encontró una asociación entre la atrofia glandular y la presencia de poliautoinmunidad, así como predominancia de los linfocitos T CD4 en los pacientes con síndrome de Sjögren. Esto resalta el posible valor de aplicar la inmunohistoquímica en las biopsias de glándula salival menor en este grupo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction.  Sjögren&#8217;s syndrome is a systemic autoimmune disease. The usefulness of immunohistochemistry in minor salivary gland biopsies has been described to be helpful in indirectly characterizing the lymphocyte phenotype in difficult diagnosis cases.  Objective.  To describe sociodemographic, clinical, serological, histopathological, and immunohistochemical variables in patients with sicca syndrome and a minor salivary gland biopsy focus score greater than or equal to one.  Materials and methods.  We conducted an observational, retrospective study that included patients under study for potential sicca syndrome whose minor salivary gland biopsy was available and had obtained a focus score greater than or equal to one. Immunohistochemistry was performed on the minor salivary gland biopsy with chromogen red staining for CD8 T lymphocytes and brown staining for CD4 T lymphocytes. Expression ratio of CD20:CD3 and CD4:CD8 markers was determined with the MoticEasyScan Pro 6&#8482; (MOTIC) device and the QuPath&#8482; software. Qualitative variables were analyzed using the chi-square or Fisher&#8217;s exact test, and quantitative variables were analyzed according to their assumption of normality.  Results.  Twenty-eight patients were analyzed: 16 patients had Sjögren&#8217;s syndrome, and 8 of them had polyautoimmunity. An association was found between atrophy in the minor salivary gland biopsy and development of polyautoimmunity (OR = 11.1; 95% CI: 1.12-112; p value = 0.033). The CD20:CD3 and CD4:CD8 ratios were normal, with no statistically significant differences between patients with and without Sjögren&#8217;s syndrome. In the subgroup of patients with Sjögren&#8217;s syndrome, CD4 T lymphocytes were predominant, with 15 cases out of 16 with CD4:CD8 ratios equal to or greater than 2:1.  Conclusions.  Glandular atrophy was associated with the development of polyautoimmunity and a predominance of CD4 T lymphocytes in patients with Sjögren&#8217;s syndrome. This finding highlights the potential value of immunohistochemistry of minor salivary gland biopsies in this group.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[síndrome de Sjögren]]></kwd>
<kwd lng="es"><![CDATA[inmunohistoquímica]]></kwd>
<kwd lng="es"><![CDATA[biopsia]]></kwd>
<kwd lng="es"><![CDATA[linfocitos]]></kwd>
<kwd lng="es"><![CDATA[enfermedades autoinmunes]]></kwd>
<kwd lng="en"><![CDATA[Sjögren&#8217;s syndrome]]></kwd>
<kwd lng="en"><![CDATA[immunohistochemistry]]></kwd>
<kwd lng="en"><![CDATA[biopsy]]></kwd>
<kwd lng="en"><![CDATA[lymphocytes]]></kwd>
<kwd lng="en"><![CDATA[autoimmune diseases]]></kwd>
</kwd-group>
</article-meta>
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