<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-5633</journal-id>
<journal-title><![CDATA[Revista Colombiana de Cardiología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Colomb. Cardiol.]]></abbrev-journal-title>
<issn>0120-5633</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Colombiana de Cardiologia. Oficina de Publicaciones]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-56332020000400330</article-id>
<article-id pub-id-type="doi">10.1016/j.rccar.2019.10.007</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Comparación de dos protocolos de antibiótico profiláctico en implantes de dispositivos de estimulación cardíaca. &#8220;COMPROFILAXIA&#8221;]]></article-title>
<article-title xml:lang="en"><![CDATA[Comparison of two prophylactic antibiotic protocols in implantable cardiac stimulation devices: &#8220;COMPROFILAXIA&#8221;]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Orjuela]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cardozo]]></surname>
<given-names><![CDATA[Laura P.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto del Corazón de Bucaramanga Departamento de Electrofisiología ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<volume>27</volume>
<numero>4</numero>
<fpage>330</fpage>
<lpage>336</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-56332020000400330&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-56332020000400330&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-56332020000400330&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  El aumento de los implantes de dispositivos de estimulación cardiaca en los últimos años, aunado a la longevidad y al perfil de morbilidad de los pacientes, ha hecho que la incidencia de infecciones asociadas a estos procedimientos aumente. Sin embargo, existe disparidad en Colombia y en el mundo respecto al esquema apropiado de profilaxis antibiótica.  Objetivo:  Evaluar la incidencia de infecciones postoperatorias con dos protocolos de antibiótico-profilaxia.  Métodos:  Ensayo clínico controlado aleatorizado en el que se incluyeron 360 pacientes que recibieron implante de dispositivos cardíacos y fueron aleatorizados en dos grupos para recibir una dosis de antibiótico (cefazolina 1 g) (240 pacientes) o tres dosis (120 pacientes). Se realizó seguimiento durante un año. El desenlace principal fue la incidencia de infecciones postoperatorias.  Resultados:  No se observó una diferencia significativa entre la incidencia de infección postoperatoria en los dos grupos (tres dosis vs. una dosis: OR crudo 0.92; IC95% 0.23 - 3.64; p 0.912), con una tasa de 2.9% (7/238) en el grupo de una dosis y de 2.7% (3/110) en el grupo de tres dosis. Tras el análisis multivariado se identificó a la enfermedad renal crónica como un predictor independiente para el desarrollo de complicaciones infecciosas (OR ajustado 4.71; IC95% 1,13 - 19,60).  Conclusión:  El uso de un protocolo de única dosis de antibiótico profiláctico una hora antes del implante de dispositivos de estimulación cardiaca parece no ser inferior al protocolo de tres dosis postoperatorias.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  The increase in implantable cardiac stimulation devices in the last few years, along with the longevity and morbidity characteristics of the patient, has led to an increase in infections associated with these procedures. However, there are differences in Colombia and in the rest of the world as regards a suitable antibiotic prophylaxis scheme.  Objective:  To evaluate the incidence of post-operative infections with two antibiotic prophylaxis protocols.  Methods:  A controlled, randomised clinical trial was performed, in which 360 patients that had received a cardiac device implant were randomised into two groups: one with 240 patients to receive one dose of antibiotic (1 g cephazolin), and another of 120 patients to receive 3 doses. The patients were followed-up for one year. The primary outcome was the incidence of post-operative infections.  Results:  No significant difference was observed in the incidence of post-operative infections between the two groups (three doses versus one dose: crude OR, 0.92; 95% CI; 0.23 - 3.64; P = .912), with a rate of 2.9% (7/238) in the one-dose group, and 2.7% (3/110) in the three-dose group. After the multivariate analysis, chronic kidney disease was identified as an independent predictor of developing infectious complications (adjusted OR = 4.71; 95% CI; 1.13 - 19.60).  Conclusion:  The use of a single-dose prophylaxis antibiotic protocol one hour before the implantation of cardiac stimulator devices does not appear to be inferior to the three-dose post-operative protocol.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Profilaxis antibiótica]]></kwd>
<kwd lng="es"><![CDATA[Desfibriladores implantables/efectos adversos]]></kwd>
<kwd lng="es"><![CDATA[Marcapaso artificial/efectos adversos]]></kwd>
<kwd lng="en"><![CDATA[Antibiotic prophylaxis]]></kwd>
<kwd lng="en"><![CDATA[Implantable defibrillators / adverse effects]]></kwd>
<kwd lng="en"><![CDATA[Artificial pacemaker / adverse effects]]></kwd>
</kwd-group>
</article-meta>
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<page-range>325-31</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
