<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-1129</journal-id>
<journal-title><![CDATA[Revista Facultad de Ingeniería]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Fac. ing.]]></abbrev-journal-title>
<issn>0121-1129</issn>
<publisher>
<publisher-name><![CDATA[Universidad Pedagógica y Tecnológica de Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-11292018000200017</article-id>
<article-id pub-id-type="doi">10.19053/01211129.v27.n48.2018.8017</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Manufacture of titanium dioxide scaffolds for medical applications]]></article-title>
<article-title xml:lang="es"><![CDATA[Elaboración da scaffolds de dióxido de titanio para aplicaciones médicas]]></article-title>
<article-title xml:lang="pt"><![CDATA[Elaboração de scaffolds de dióxido de titânio para aplicações médicas]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuervo-Osorio]]></surname>
<given-names><![CDATA[Giovanni]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jiménez-Valencia]]></surname>
<given-names><![CDATA[Ana María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mosquera-Agualimpia]]></surname>
<given-names><![CDATA[Cristian]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Escobar-Sierra]]></surname>
<given-names><![CDATA[Diana Marcela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Antioquia  ]]></institution>
<addr-line><![CDATA[Medellín Antioquía]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Antioquia  ]]></institution>
<addr-line><![CDATA[Medellín Antioquía]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Antioquia  ]]></institution>
<addr-line><![CDATA[Medellín Antioquía]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Antioquía  ]]></institution>
<addr-line><![CDATA[Medellín Antioquía]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2018</year>
</pub-date>
<volume>27</volume>
<numero>48</numero>
<fpage>17</fpage>
<lpage>25</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-11292018000200017&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-11292018000200017&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-11292018000200017&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The skeletal system is vulnerable to injuries and bone loss over the years, making the use of autologous or allogeneic implants necessary. However, these implants have complications, such as the limited amount of bone to be extracted and the cell death at the extraction site; hence, biomaterials have been developed as platforms for cell growth (scaffolds). Biomaterials and bones have similar properties that facilitate the integration between the material and the bone tissue, helping the tissue to regenerate. Traditional ceramic implants are hydroxyapatite, but given their low mechanical properties, they have been replaced with better inert ceramics. Therefore, this study aims at manufacturing titanium dioxide scaffolds through various techniques, using collagen, polyvinyl alcohol (PVA), sodium chloride, and corn flour as binders to influence pore size. Scaffolds were characterized by a Scanning Electron Microscope (SEM) and evaluated by compression and degradability tests in a Simulated Body Fluid (SBF). The prepared scaffolds had mechanical behaviors with ranges within the bone parameters; among them, the scaffold obtained by infiltration with 10% PVA presented values of compression strength (6.75 MPa), elastic modulus (0.23 GPa), and porosities (54-67%) closer to the values of the trabecular bone.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El Sistema esquelético es vulnerable a lesiones y a perder hueso a lo largo de los años, lo que hace necesario el uso de implantes autólogos o alogénicos; sin embargo, estos implantes tienen complicaciones, como la cantidad limitada de hueso que se extrae y la muerte celular en el sitio de extracción; por lo tanto, se han desarrollado biomateriales como plataformas para el crecimiento celular (scaffolds). Los biomateriales tienen propiedades similares a las del hueso, lo que facilita su integración con el tejido óseo, ayudando a la regeneración de este. Tradicionales los implantes de cerámica son de hidroxiapatitas, pero, debido a sus pobres propiedades mecánicas, han sido reemplazados por cerámicas inertes, que tienen mejores propiedades mecánicas. Por lo tanto, el objetivo de este estudio fue fabricar scaffolds de dióxido de titanio, por medio de diferentes técnicas, utilizando colágeno, polivinil alcohol (PVA), cloruro de sodio y harina de maíz como aglutinante para influenciar el tamaño del poro. Los scaffolds se caracterizaron por medio de microscopía electrónica de barrido (SEM) y se evaluaron con pruebas de compresión y degradabilidad en un fluido corporal simulado (SBF). Los scaffolds elaborados presentaron comportamientos mecánicos que están entre el rango normal del hueso; el scaffold obtenido por medio de infiltración, con 10 % de PVA, presentó valores de fuerza de compresión (6.75 MPa), módulos elásticos (0.23 GPa) y porosidad (54-67 %) cercanos a aquellos reportados para el hueso trabecular.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo O Sistema esquelético é vulnerável a lesões e a perder osso ao longo dos anos, o que faz necessário o uso de implantes autólogos ou alogênicos; porém, estes implantes têm complicações, como a quantidade limitada de osso que se extrai e a morte celular no lugar de extração; portanto, têm sido desenvolvidos biomateriais como plataformas para o crescimento celular (scaffolds). Os biomateriais têm propriedades similares às do osso, o que facilita sua integração com o tecido ósseo, ajudando à regeneração do mesmo. Tradicionais os implantes de cerâmica são de hidroxiapatitas, mas, devido a suas pobres propriedades mecânicas, têm sido substituídos por cerâmicas inertes, que têm melhores propriedades mecânicas. Portanto, o objetivo deste estudo foi fabricar scaffolds de dióxido de titânio, por meio de diferentes técnicas, utilizando colágeno, polivinil álcool (PVA), cloreto de sódio e farinha de milho como aglutinante para influenciar o tamanho do poro. Os scaffolds caracterizaram-se por meio de microscopia eletrônica de varredura (SEM) e avaliaram-se com provas de compressão e degradabilidade em um fluído corporal simulado (SBF). Os scaffolds elaborados apresentaram comportamentos mecânicos que estão entre a faixa normal do osso; o scaffold obtido por meio de infiltração, com 10% de PVA, apresentou valores de força de compressão (6.75 MPa), módulos elásticos (0.23 GPa) e porosidade (54-67%) próximos a aqueles reportados para o osso trabecular.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[compression molding]]></kwd>
<kwd lng="en"><![CDATA[infiltration]]></kwd>
<kwd lng="en"><![CDATA[lyophilization]]></kwd>
<kwd lng="en"><![CDATA[scaffolds]]></kwd>
<kwd lng="es"><![CDATA[infiltración]]></kwd>
<kwd lng="es"><![CDATA[moldeo por compresión]]></kwd>
<kwd lng="es"><![CDATA[liofilización]]></kwd>
<kwd lng="es"><![CDATA[scaffolds]]></kwd>
<kwd lng="pt"><![CDATA[infiltração]]></kwd>
<kwd lng="pt"><![CDATA[moldagem por compressão]]></kwd>
<kwd lng="pt"><![CDATA[liofilização]]></kwd>
<kwd lng="pt"><![CDATA[scaffolds]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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