<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-8123</journal-id>
<journal-title><![CDATA[Revista Colombiana de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev.Colomb.Reumatol.]]></abbrev-journal-title>
<issn>0121-8123</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Reumatología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-81232024000100018</article-id>
<article-id pub-id-type="doi">10.1016/j.rcreu.2022.03.006.</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Psoriatic march: A view from pathophysiology to cardiovascular risk]]></article-title>
<article-title xml:lang="es"><![CDATA[Marcha psoriásica: una mirada desde la fisiopatología hasta el riesgo cardiovascular]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres-Soto]]></surname>
<given-names><![CDATA[Sneider Alexander]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva-Quintero]]></surname>
<given-names><![CDATA[Laura Andrea]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas-Zuleta]]></surname>
<given-names><![CDATA[Wilmer Gerardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad CES Dermatology Residency Faculty of Medicine]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Medicarte SAS  ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Medicarte SAS  ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2024</year>
</pub-date>
<volume>31</volume>
<numero>1</numero>
<fpage>18</fpage>
<lpage>28</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-81232024000100018&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-81232024000100018&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-81232024000100018&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Psoriasis is a disease that is not limited to skin involvement, the importance of systemic compromise is recognized more than ever, especially because of the associated comorbidities, which are explained by the marked chronic systemic inflammatory response mediated by pro-inflammatory cytokines (mainly TNF-&#945;, IL23, IL 17), which play an important role in the induction of insulin resistance, endothelial dysfunction, accelerated atherosclerosis and the increased risk of cardio-cerebrovascular events. The relationship with these outcomes has been demonstrated and hence the concept of psoriatic march, a term that is gaining increasing importance aimed at maintaining and reinforcing the approach to a skin disease with systemic compromise, associated morbidity and mortality that can be preventable and manageable. The pathophysiological mechanisms that explain these phenomena are variable, however, new concepts have been identified, which have made it possible to improve the current approach to the disease and thus establish mechanisms to reduce cardiovascular risk in patients with psoriasis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La psoriasis es una enfermedad que va más allá de la afectación exclusivamente cutánea, cada día se reconoce más la importancia del compromiso sistémico, en especial por las comorbilidades asociadas. Dichas comorbilidades se explican por la marcada respuesta inflamatoria sistémica crónica mediada por citoquinas proinflamatorias (principalmente TNF-&#945;, IL-23 e IL-17), las cuales desempeñan un papel importante en la inducción de la resistencia a la insulina, la disfunción endotelial, la aterosclerosis acelerada y el aumento del riesgo de eventos cardio-cerebrovasculares. La relación con estos desenlaces ha sido demostrada, y es allí donde surge el concepto de marcha psoriásica, un término que cobra cada día más importancia, cuyo objetivo es mantener y reforzar el enfoque de una enfermedad cutánea con compromiso sistémico, morbimortalidad asociada que puede ser prevenible y manejable. Los mecanismos fisiopatológicos que explican estos fenómenos son variables, sin embargo, se han dilucidado nuevos conceptos que han permitido mejorar el enfoque actual de la enfermedad, y así establecer mecanismos para disminuir el riesgo cardiovascular en pacientes con psoriasis.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Psoriasis]]></kwd>
<kwd lng="en"><![CDATA[Physiopathology]]></kwd>
<kwd lng="en"><![CDATA[Inflammatory markers]]></kwd>
<kwd lng="en"><![CDATA[Endothelial cells]]></kwd>
<kwd lng="en"><![CDATA[Insulin resistance]]></kwd>
<kwd lng="en"><![CDATA[Atherosclerosis]]></kwd>
<kwd lng="en"><![CDATA[Vascular diseases]]></kwd>
<kwd lng="es"><![CDATA[Psoriasis]]></kwd>
<kwd lng="es"><![CDATA[Fisiopatología]]></kwd>
<kwd lng="es"><![CDATA[Marcadores inflamatorios]]></kwd>
<kwd lng="es"><![CDATA[Células endoteliales]]></kwd>
<kwd lng="es"><![CDATA[Resistencia a la insulina]]></kwd>
<kwd lng="es"><![CDATA[Ateroesclerosis]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad cardiovascular]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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