<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0122-3461</journal-id>
<journal-title><![CDATA[Ingeniería y Desarrollo]]></journal-title>
<abbrev-journal-title><![CDATA[Ing. Desarro.]]></abbrev-journal-title>
<issn>0122-3461</issn>
<publisher>
<publisher-name><![CDATA[Fundación Universidad del Norte]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0122-34612019000100088</article-id>
<article-id pub-id-type="doi">10.14482/inde.37.1.6201</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Fabricación y caracterización de nanopartículas de plata con potencial uso en el tratamiento del cáncer de piel]]></article-title>
<article-title xml:lang="en"><![CDATA[Fabrication and characterization of silver nanoparticles with potential use in the treatment of skin cancer]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gallo Ramírez]]></surname>
<given-names><![CDATA[Juan Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ossa Orozco]]></surname>
<given-names><![CDATA[Claudia Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Antioquia  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Antioquia  ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<volume>37</volume>
<numero>1</numero>
<fpage>88</fpage>
<lpage>104</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0122-34612019000100088&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0122-34612019000100088&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0122-34612019000100088&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El cáncer de piel tipo carcinoma es la patología de mayor frecuencia epidemiológica a nivel mundial. Sus tratamientos convencionales se clasifican según el tipo de cáncer de piel que presenta el paciente y su ubicación. Para su tratamiento se utilizan procedimientos como, por ejemplo, la escisión con evaluación de márgenes, la radioterapia, el curetaje y electrodisección, criocirugía, cirugía micrográfica de Mohs, terapia fotodinámica, el 5-fluorouracilo tópico, la terapia con imiquimod tópico y el láser con dióxido de carbono. A pesar del abanico de técnicas terapéuticas con las que se cuenta, estas terapias, por lo general, se acompañan de efectos secundarios. Es por esto que cobra interés el estudio de nuevas alternativas basadas en ingeniería de tejidos que potencialmente pueden aumentar la efectividad de los resultados anticancerígenos y disminuir la aparición de efectos adversos. Entre las técnicas de nanomedicina usadas en cáncer se encuentran las nanopartículas (NPs), las cuales son biocompatibles y han mostrado efectividad en modelos animales frente a la muerte de células cancerígenas y la disminución del tamaño de tumores, ya que al absorber fuertemente la radiación cercana al infrarrojo actúan como fuentes de hipertermia local. Con el fin de aumentar los efectos biológicos de las adiciones, se puede utilizar la biofuncionalización o activación superficial para asegurar el anclaje de los surfactantes, proteínas y factores tisulares necesarios. En el presente proyecto se obtuvieron nanopartículas de plata por medio del método de reducción química, en el cual se le modificaron varios parámetros a fin de estandarizar el tamaño de las nanopartículas, punto clave en el tratamiento del cáncer. Luego del método de síntesis se llevó a cabo un proceso adicional de biofuncionalización mediante el polímero polietilenglicol (PEG) para mejorar las propiedades de anclaje y biocompatibilidad de las nanopartículas. En la caracterización de las nanopartículas se procedió con técnicas de microscopía electrónica de transmisión; además, espectrofotometría UV-Vis y un ensayo de viabilidad y citotoxicidad de las nanopartículas. Se concluyó que con el procedimiento implementado se pueden sintetizar nanopartículas de plata para un potencial uso en el tratamiento de cáncer de piel.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Carcinoma-like skin cancer is the world&#8217;s most frequently diagnosed pathology. Its conventional treatments are classified according to the type of skin cancer that the patient presents and its location, and include procedures such as excision with margins evaluation, radiotherapy, curettage and electro dissection, cryosurgery, surgery Mohs micrograph, photodynamic therapy, topical 5-fluorouracil, topical Imiquimod therapy and laser with carbon dioxide. Despite the range of therapeutic techniques available, these therapies are usually accompanied by side effects, which is why it is interesting to study new alternatives based on tissue engineering that can potentially increase the effectiveness of anticancer results and decrease the occurrence of adverse effects. Among the Nanomedicine techniques used in cancer, nanoparticles (NPs), which are biocompatible and have been shown to be effective in animal models against the death of cancer cells and the decrease of tumor size, since by strongly absorbing near-infrared radiation they act as sources of local hyperthermia. In order to increase the biological effects of NPs, biofunctionalization or surface activation may be used to ensure anchorage of surfactants, proteins and tissue factors required. In the present project silver nanoparticles obtained through the nucleation and reduction chemical method, in which several parameters were modified to standardize the size of the nanoparticles, a key point in the treatment of cancer, after synthesis method was made an additional process of biofunctionalisation by the polyethylene glycol (PEG) polymer to improve the anchoring and biocompatibility properties of the nanoparticles. For the characterization of the nanoparticles, we proceeded with scanning and transmission electron microscopy techniques, in addition to spectophometric UV-Vis and an assay to determine the viability and cytotoxicity of nanoparticles. It was concluded that with the implemented procedure could be synthesized and characterized nanoparticles for their potential use in the treatment of skin cancer.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[biocompatibilidad]]></kwd>
<kwd lng="es"><![CDATA[biofuncionalización]]></kwd>
<kwd lng="es"><![CDATA[cáncer de piel]]></kwd>
<kwd lng="es"><![CDATA[ingeniería de tejidos]]></kwd>
<kwd lng="es"><![CDATA[nanopartículas de plata]]></kwd>
<kwd lng="es"><![CDATA[síntesis]]></kwd>
<kwd lng="en"><![CDATA[biocompatibility]]></kwd>
<kwd lng="en"><![CDATA[biofunctionalization]]></kwd>
<kwd lng="en"><![CDATA[skin cancer]]></kwd>
<kwd lng="en"><![CDATA[tissue engineering]]></kwd>
<kwd lng="en"><![CDATA[silver nanoparticles]]></kwd>
<kwd lng="en"><![CDATA[synthesis]]></kwd>
</kwd-group>
</article-meta>
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