<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0122-9761</journal-id>
<journal-title><![CDATA[Boletín de Investigaciones Marinas y Costeras - INVEMAR]]></journal-title>
<abbrev-journal-title><![CDATA[Bol. investig. mar. Costeras]]></abbrev-journal-title>
<issn>0122-9761</issn>
<publisher>
<publisher-name><![CDATA[INSTITUTO DE INVESTIGACIONES MARINAS Y COSTERAS "JOSE BENITO VIVES DE ANDRÉIS" (INVEMAR)    INSTITUTO DE INVESTIGACIONES MARINAS Y COSTERAS -JOSE BENITO VIVES DE ANDRÉIS- (INVEMAR)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0122-97612016000200237</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[PRIMEROS PASOS HACIA LA LOCALIZACIÓN CELULAR DEL (+)-DISCODERMÓLIDO, UN POTENTE POLICÉTIDO ANTITUMORAL PRODUCIDO POR LA ESPONJA MARINA DEL CARIBE DISCODERMIA DISSOLUTA]]></article-title>
<article-title xml:lang="en"><![CDATA[First steps towards cellular localization of (+)-cUscoderinolide, a potent antitumoral poliketide biosynthesized by the Caribbean marine sponge Discodermia dissoluta]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Puentes]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-León]]></surname>
<given-names><![CDATA[Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz]]></surname>
<given-names><![CDATA[Cesar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zea]]></surname>
<given-names><![CDATA[Sven]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pomponi]]></surname>
<given-names><![CDATA[Shirley]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Colombia  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de Investigaciones Marinas y Costeras - INVEMAR  ]]></institution>
<addr-line><![CDATA[Santa Marta ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Avignon Université  ]]></institution>
<addr-line><![CDATA[Marseille ]]></addr-line>
<country>France</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Centro de Estudios en Ciencias del Mar - CECIMAR  ]]></institution>
<addr-line><![CDATA[Santa Marta ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Atlantic University  ]]></institution>
<addr-line><![CDATA[Florida ]]></addr-line>
<country>USA</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<volume>45</volume>
<numero>2</numero>
<fpage>237</fpage>
<lpage>251</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0122-97612016000200237&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0122-97612016000200237&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0122-97612016000200237&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Identificar la célula productora de un metabolito bioactivo permite enfocar los esfuerzos de cultivo celular para su producción in-vitro, así como elucidar la posible función fisiológica del metabolito. La esponja marina del Caribe Discodermia dissoluta produce el policétido (+)-discodermólido, un potente antitumoral que ha llegado a fase clínica de investigación en humanos. En este trabajo se avanzó en la identificación de las células productoras mediante disociación celular, separación en fracciones por centrifugación en gradientes de densidad de Percoll® y detección de la presencia de (+)-discodermólido mediante cromatografía de capa delgada. Las fracciones mostraron células de diferentes características morfológicas, entre las que se encuentran cianobacterias, bacterias filamentosas, coanocitos, arqueocitos, entre otras. Se pudo identificar un patrón irregular pero consistente de producción de (+)-discodermólido en las fracciones que contenían uno o más tipos de células granulares de la esponja, indicando que la producción del metabolito parece estar asociada con la esponja y no con los microorganismos asociados.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Identification of bioactive metabolite cell producers allow driving cell culture experiments for in vitro production, just as elucidation of the possible physiologic function of metabolites. The Caribbean marine sponge Discodermia dissoluta produces the polyketide (+)-discodermolide, a potent antitumoral that has reached clinic trials in humans. In this research, progress was made in identifying the producing cells by cell dissociation, separation into fractions by centrifugation on Percoll® density gradients, and detection of (+)-discodermolide presence by thin layer chromatography. The fractions recovered showed cells of different morphological characteristics, including cyanobacteria, filamentous bacteria, choanocytes, archaeocytes, among others. It was possible to identify an irregular but consistent pattern of (+)-dicordemolide production in the fractions that contained one or more kind of sponge granular cells, indicating that metabolite production seems to be related to the sponge and not with the associated microorganisms.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Discodermia dissoluta]]></kwd>
<kwd lng="es"><![CDATA[(+)-Discodermólido]]></kwd>
<kwd lng="es"><![CDATA[Disociación celular]]></kwd>
<kwd lng="es"><![CDATA[Anticancerígeno]]></kwd>
<kwd lng="en"><![CDATA[Discodermia dissoluta]]></kwd>
<kwd lng="en"><![CDATA[(+)-Discodermolide]]></kwd>
<kwd lng="en"><![CDATA[Cell dissociation]]></kwd>
<kwd lng="en"><![CDATA[Anticancer agent]]></kwd>
</kwd-group>
</article-meta>
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