<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2500-5006</journal-id>
<journal-title><![CDATA[Revista Colombiana de Nefrología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colom. nefrol.]]></abbrev-journal-title>
<issn>2500-5006</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Nefrología e Hipertensión Arterial]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2500-50062020000100060</article-id>
<article-id pub-id-type="doi">10.22265/acnef.7.1.356</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[El continuo cardiorrenal: una propuesta para la prevención de las enfermedades cardiovasculares y renales]]></article-title>
<article-title xml:lang="en"><![CDATA[Cardiorenal continuum: A proposal for the prevention of cardiovascular and renal disease]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Maimi]]></surname>
<given-names><![CDATA[Pablo Amair]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodulfo]]></surname>
<given-names><![CDATA[Ildefonzo Arocha]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Sociedad Venezolana de Cardiología  ]]></institution>
<addr-line><![CDATA[Caracas ]]></addr-line>
<country>Venezuela</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<volume>7</volume>
<numero>1</numero>
<fpage>60</fpage>
<lpage>69</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S2500-50062020000100060&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S2500-50062020000100060&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S2500-50062020000100060&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Los factores de riesgo cardiovascular (FRCV) como hipertensión arterial (HTA), diabetes mellitus tipo 2 (DM2) y dislipidemia suelen estar involucrados con la enfermedad renal crónica (ERC) y su contribución a la morbilidad cardiovascular. La disfunción endotelial difusa y la aterosclerosis están conceptualizadas como parte de la fisiopatología de la ERC en diabéticos y no diabéticos, particularmente en ancianos. La edad es el principal determinante de la tasa de filtración glomerular (TFG) y flujo plasmático renal efectivo y se ha reportado que la presencia de HTA favorece la declinación en la depuración de creatinina. La dislipidemia puede afectar directamente el riñón causando trastorno renal lipídico (lipotoxicidad renal) e indirectamente a través de la inflamación sistémica y estrés oxidativo, agresión vascular y cambios humorales y de otras moléculas de señalización con acción renal. Varios estudios transversales han encontrado que el deterioro a la tolerancia glucosada y la presencia de hipertrofia ventricular izquierda están asociados con un aumento en la pendiente de la relación inversa entre edad y TFG en sujetos con HTA no tratada. La mayoría de las drogas empleadas para reducir la carga de los FRCV también son beneficiosas para la función renal. De tal forma que se propone al continuo cardiorrenal como una estrategia preventiva para proteger ambos órganos y reducir el impacto deletéreo de los FRCV sobre la función renal partiendo del punto de vista de un binomio funcional y fisiopatológico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Cardiovascular risk factors such as arterial hypertension, type 2 diabetes mellitus (DM2) and dyslipidemia are commonly involved with chronic kidney disease (CKD) and its contribution to long-term cardiovascular morbidity. Diffuse endothelial dysfunction and atherosclerosis are believed to be part of the common pathophysiology in diabetic and non-diabetic CKD, particularly in the elderly. Age is the main determinant of glomerular filtration rate (GFR) and effective renal plasma flow and has been reported that the presence of hypertension at baseline enhances the yearly decline in creatinine clearance. Dyslipidemia may directly affect the kidney by causing deleterious renal lipid disturbances (renal lipotoxicity), as well as indirectly through systemic inflammation and oxidative stress, vascular injury, hormones change and other signaling molecules with renal action. Several cross-sectional studies found that impaired glucose tolerance, as well as the presence of left ventricular hypertrophy, was associated with an increase in the slope of the inverse relationship between age and GFR in subjects with never-treated essential hypertension. Most of the drugs used to reduce the burden of risk factor on cardiovascular disease also benefit the renal function. So, we propose the cardiorenal continuum as a preventive strategy to protect both organ and reduce the deleterious impact of the cardiovascular risk factor on the renal function considering both organs as a functional and physiopathological binomial.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[continuo cardiorrenal]]></kwd>
<kwd lng="es"><![CDATA[enfermedad cardiovascular]]></kwd>
<kwd lng="es"><![CDATA[enfermedad renal crónica]]></kwd>
<kwd lng="es"><![CDATA[albuminuria]]></kwd>
<kwd lng="es"><![CDATA[factores de riesgo]]></kwd>
<kwd lng="es"><![CDATA[hipertensión arterial]]></kwd>
<kwd lng="es"><![CDATA[dislipidemia]]></kwd>
<kwd lng="es"><![CDATA[diabetes]]></kwd>
<kwd lng="en"><![CDATA[Cardiorenal continuum]]></kwd>
<kwd lng="en"><![CDATA[cardiovascular disease]]></kwd>
<kwd lng="en"><![CDATA[chronic kidney disease]]></kwd>
<kwd lng="en"><![CDATA[albuminuria]]></kwd>
<kwd lng="en"><![CDATA[risk factors]]></kwd>
<kwd lng="en"><![CDATA[hypertension]]></kwd>
<kwd lng="en"><![CDATA[dyslipidemia]]></kwd>
<kwd lng="en"><![CDATA[diabetes]]></kwd>
</kwd-group>
</article-meta>
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