<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-2448</journal-id>
<journal-title><![CDATA[Acta Medica Colombiana]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Med Colomb]]></abbrev-journal-title>
<issn>0120-2448</issn>
<publisher>
<publisher-name><![CDATA[Asociacion Colombiana de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-24482021000400049</article-id>
<article-id pub-id-type="doi">10.36104/amc.2021.2081</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Losartan-induced DRESS syndrome]]></article-title>
<article-title xml:lang="es"><![CDATA[Síndrome de DRESS por losartán]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[OQUENDO-GAHONA]]></surname>
<given-names><![CDATA[DIEGO ARMANDO]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[ZAMORA-SUÁREZ]]></surname>
<given-names><![CDATA[ADRIANA]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[ROMERO-MÉNDEZ]]></surname>
<given-names><![CDATA[CINDY CONSUELO]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[CIFUENTES-GONZÁLEZ]]></surname>
<given-names><![CDATA[JUAN CAMILO]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Surcolombiana  ]]></institution>
<addr-line><![CDATA[Neiva ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Surcolombiana Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Neiva ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Surcolombiana  ]]></institution>
<addr-line><![CDATA[Neiva ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Surcolombiana  ]]></institution>
<addr-line><![CDATA[Neiva ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>46</volume>
<numero>4</numero>
<fpage>49</fpage>
<lpage>53</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-24482021000400049&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-24482021000400049&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-24482021000400049&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: drug reactions with eosinophilia and systemic symptoms, known as DRESS syndrome, are a hypersensitivity reaction to medications which can lead to skin lesions and internal organ involvement. This syndrome has typically been associated with a wide variety of medications, including aromatic anticonvulsants, allopurinol and antibiotics as the main culprits.  Objective: we present the case of a patient with DRESS syndrome secondary to losartan, manifesting skin symptoms and mild hepatic involvement. Up until now, there have been no reports of losartan as the cause of this condition. Prompt treatment was instated including the withdrawal of the offending medication and initiation of oral systemic steroids, with a satisfactory response.  Conclusion: caregivers should be alert to the appearance of skin lesions with the use of different groups of medications, not just those typically reported, since any medication could potentially cause a hypersensitivity reaction. (Acta Med Colomb 2021; 46. DOI:https://doi.org/10.36104/amc.2021.2081).]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: la reacción a fármacos con eosinofília y síntomas sistémicos conocido como síndrome DRESS corresponde a una reacción de hipersensibilidad medicamentosa, que puede llevar a la presentación de lesiones dermatológicas y compromiso de órganos internos. Clásicamente se ha asociado a una gran variedad de fármacos entre los cuales se incluyen anticonvulsivantes aromáticos, alopurinol y antibióticos como los principales responsables.  Objetivo: se presenta el caso de un paciente con síndrome de DRESS secundario a losartán manifestando síntomas cutáneos y compromiso hepático leve, fármaco para el cual hasta la fecha no existen reportes de presentar relación de causalidad con esta patología. Se instauró tratamiento de forma temprana incluyendo el retiro del medicamento responsable e inicio de corticoide sistémico oral observándose una adecuada respuesta  Conclusión: se debe estar atento a la aparición de lesiones dermatológicas con el uso de diferentes grupos de medicamentos, no sólo a los reportados clásicamente ya que cualquier fármaco podría ser potencial responsable de reacción de hipersensibilidad. (Acta Med Colomb 2021; 46. DOI:https://doi.org/10.36104/amc.2021.2081).]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[DRESS syndrome]]></kwd>
<kwd lng="en"><![CDATA[losartan]]></kwd>
<kwd lng="en"><![CDATA[drug hypersensitivity]]></kwd>
<kwd lng="es"><![CDATA[síndrome de DRESS]]></kwd>
<kwd lng="es"><![CDATA[losartán]]></kwd>
<kwd lng="es"><![CDATA[hipersensibilidad farmacológica]]></kwd>
</kwd-group>
</article-meta>
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