<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-5552</journal-id>
<journal-title><![CDATA[Revista Salud Uninorte]]></journal-title>
<abbrev-journal-title><![CDATA[Salud, Barranquilla]]></abbrev-journal-title>
<issn>0120-5552</issn>
<publisher>
<publisher-name><![CDATA[Fundación Universidad del Norte, División de Ciencias de la]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-55522022000200473</article-id>
<article-id pub-id-type="doi">10.14482/sun.38.2.616.94</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evaluación del polimorfismo TLR2 Arg753Gln como posible marcador de riesgo para el desarrollo de sepsis]]></article-title>
<article-title xml:lang="en"><![CDATA[Evaluation of TLR2 Arg753Gln Polymorphism as a Possible Risk Marker for Sepsis Development]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[PANIAGUA NOGUE]]></surname>
<given-names><![CDATA[ROXANA]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[ROJANO RADA]]></surname>
<given-names><![CDATA[JAIRO]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[FERNÁNDEZ-MESTRE]]></surname>
<given-names><![CDATA[MERCEDES]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Central del Instituto Venezolano de los Seguros Sociales "Dr. Miguel Pérez Carreño"  ]]></institution>
<addr-line><![CDATA[Caracas ]]></addr-line>
<country>Venezuela</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Central del Instituto Venezolano de los Seguros Sociales "Dr. Miguel Pérez Carreno"  ]]></institution>
<addr-line><![CDATA[Caracas ]]></addr-line>
<country>Venezuela</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Venezolano de Investigaciones Científicas  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2022</year>
</pub-date>
<volume>38</volume>
<numero>2</numero>
<fpage>473</fpage>
<lpage>490</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-55522022000200473&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-55522022000200473&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-55522022000200473&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Objetivo: Evaluar el polimorfismo TLR2 Arg753Gln como posible marcador de riesgo para el desarrollo de sepsis  Materiales y métodos: Estudio de asociación, el cual incluyó 183 individuos venezolanos no relacionados, agrupados en individuos sépticos (n=50), hospitalizados en el área de emergencia del Hospital Central del Instituto Venezolano de los Seguros Sociales -Dr. Miguel Pérez Carreño-, e individuos aparentemente sanos (n=133). El polimorfismo TLR2 Arg753Gln se determinó utilizando la técnica reacción en cadena de la polimerasa con iniciadores de secuencias específicas.  Resultados: Se observó en el grupo de pacientes con escala SOFA en el rango entre 6-9 una mayor frecuencia de fallecimientos con respecto al grupo de pacientes con escala SOFA en el rango entre 0-5 (OR: 8.5; IC 95%: 2.33-30.90, p= 0,000357). El polimorfismo Arg753Gln del gen TLR2 está ausente en los pacientes con diagnóstico de sepsis.  Conclusión: Se verificó que la escala SOFA es un sistema que permite predecir la mortalidad. La ausencia del polimorfismo Arg753Gln del gen TLR2 en el grupo de pacientes sépticos y una baja frecuencia del mismo en los individuos aparentemente sanos, sugiere la rareza de este polimorfismo en la población venezolana. Consecuentemente, se requiere incrementar el tamaño de la muestra para poder comprobar si es un marcador de riesgo para el desarrollo de sepsis en nuestra población.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Objective: To evaluate the TLR2 Arg753Gln polymorphism as a possible risk marker for sepsis development.  Materials and Methods: Association study which included 183 unrelated Venezuelan individuals, divided into two groups: patients with sepsis (n = 50), hospitalized in the emergency area of the Central Hospital of the Venezuelan Institute of Social Security "Dr. Miguel Pérez Carreño", and apparently healthy individuals (n = 133). The TLR2 Arg753Gln polymorphism was determined using the polymerase chain reaction technique with specific sequence primers.  Results: A higher death rate was observed among the group of patients with the SOFA scale range between 6-9, compared to the group of patients with the SOFA scale range between 0-5 (OR: 8.5; 95% CI: 2.33-30.90, p = 0.000357). The Arg753Gln polymorphism of the TLR2 gene is absent in patients diagnosed with sepsis.  Conclusion: It was verified that the SOFA scale is a useful system to predict the mortality rate associated with sepsis. The absence of the Arg753Gln polymorphism of the TLR2 gene among the group of patients with sepsis diagnosis and its low frequency in apparently healthy individuals suggests the rarity of this polymorphism in the Venezuelan population. Consequently, it is necessary to increase the size of the sample to be able to evaluate whether it can be considered as a risk marker for sepsis development in our population.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[polimorfismo, TLR2]]></kwd>
<kwd lng="es"><![CDATA[Sepsis, Mortalidad, SOFA]]></kwd>
<kwd lng="en"><![CDATA[Polymorphism]]></kwd>
<kwd lng="en"><![CDATA[TLR2]]></kwd>
<kwd lng="en"><![CDATA[Sepsis]]></kwd>
<kwd lng="en"><![CDATA[Mortality]]></kwd>
<kwd lng="en"><![CDATA[SOFA]]></kwd>
</kwd-group>
</article-meta>
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