<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-5633</journal-id>
<journal-title><![CDATA[Revista Colombiana de Cardiología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Colomb. Cardiol.]]></abbrev-journal-title>
<issn>0120-5633</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Colombiana de Cardiologia. Oficina de Publicaciones]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-56332023000500218</article-id>
<article-id pub-id-type="doi">10.24875/rccar.21000099</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evaluación de la disfunción inmunológica en una unidad de cuidado intensivo pediátrico: un estudio observacional]]></article-title>
<article-title xml:lang="en"><![CDATA[Evaluation of immune dysfunction in a pediatric intensive care unit: an observational study]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chaverra]]></surname>
<given-names><![CDATA[Yury]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Medina]]></surname>
<given-names><![CDATA[Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guzmán]]></surname>
<given-names><![CDATA[María C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Izquierdo]]></surname>
<given-names><![CDATA[Ledys M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[Mario]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad El Bosque Departamento de Pediatría ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad El Bosque Cuidado Intensivo Pediátrico Medicina Crítica]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Cardiovascular de Cundinamarca Unidad de Cuidado Intensivo Pediátrico ]]></institution>
<addr-line><![CDATA[Soacha ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Militar Central Unidad de Cuidado Intensivo ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad El Bosque Departamento Vicerrectoría de Investigaciones ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2023</year>
</pub-date>
<volume>30</volume>
<numero>5</numero>
<fpage>218</fpage>
<lpage>225</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-56332023000500218&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-56332023000500218&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-56332023000500218&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: La disfunción inmunológica en el paciente críticamente enfermo es un compromiso de un sistema muy poco estudiado; adicionalmente, en la población infantil aún faltan guías que orienten la evaluación del sistema inmunológico.  Objetivo: Determinar la asociación de disfunción inmunológica y los desenlaces en los pacientes que ingresan a la unidad de cuidado intensivo pediátrico.  Materiales y método: Estudio observacional, con componente analítico, llevado a cabo durante cuatro años, en el que se revisaron los expedientes de todos los pacientes pediátricos consecutivos con estancia en la unidad de cuidados intensivos a quienes, por criterios médicos, se les realizó perfil inmunológico.  Resultados: Durante el período de estudio se reportaron 188 pacientes quienes cumplieron con los criterios de inclusión. Se presentó disfunción inmunológica en el 83% de los casos y enfermedad cardiaca en el 65%. La disfunción inmunológica se asoció con peores desenlaces medidos en mortalidad (37 vs. 9%; p = 0.0021), tiempo de estancia mayor a 14 días (46 vs. 14%; p &lt; 0.0001) y disfunción multiorgánica (72 vs. 25%; p &lt; 0.0001).  Conclusión: La disfunción inmunológica es frecuente en los pacientes que ingresan a la unidad de cuidado intensivo pediátrico y se asocia con un aumento de la mortalidad, la duración de la ventilación mecánica invasiva y la duración de la estancia en la unidad de cuidado intensivo pediátrico. Muchos factores se asociaron con el desarrollo de disfunción inmunológica en esta población. Se necesitan estudios prospectivos para dilucidar el manejo óptimo de la disfunción inmunológica en el paciente crítico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Immune dysfunction in critical patients has not been clearly defined and has been insufficiently researched, particularly in pediatrics. Guidelines to standardize the immune system assessment and for routine use in clinical practice are lacking.  Objective: To determine the association between immune dysfunction (here understood as the reduction of immunoglobulins and/or of the absolute count or populations of lymphocytes) and the outcome of patients admitted to the pediatric intensive care unit.  Materials and method: This was an observational, analytical, descriptive, retrospective study, conducted over four years. The records of all patients who were admitted to the pediatric intensive care unit and had an immunity profile done were included in the database. Demographic and clinical variables were compared between patients with and without immune dysfunction.  Results: A total of 188 patients with an immune profile were identified; 83% of patients had immune dysfunction and 65% had heart disease. The presence of immune dysfunction was associated with worse outcomes measured in mortality (37 vs. 9% p = 0.0021), length of stay greater than 14 days (46 vs. 14%; p &lt; 0.0001) and multiple organ dysfunction syndrome (72 vs. 25%; p &lt; 0.0001).  Conclusion: Immune dysfunction is frequent in patients with a difficult disease course and in our study sample. It was found to be associated with increased mortality, duration of invasive mechanical ventilation and length of stay in the pediatric intensive care unit. Further prospective studies with other biomarkers are needed to determine the immune compromise and its impact on outcomes in the critically ill children.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Disfunción inmunológica]]></kwd>
<kwd lng="es"><![CDATA[Pediatría]]></kwd>
<kwd lng="es"><![CDATA[Cardiopatía]]></kwd>
<kwd lng="es"><![CDATA[Unidad de cuidado intensivo pediátrico]]></kwd>
<kwd lng="es"><![CDATA[Linfopenia]]></kwd>
<kwd lng="es"><![CDATA[Hipogammaglobulinemia]]></kwd>
<kwd lng="en"><![CDATA[Immune dysfunction]]></kwd>
<kwd lng="en"><![CDATA[Pediatrics]]></kwd>
<kwd lng="en"><![CDATA[heart disease]]></kwd>
<kwd lng="en"><![CDATA[Pediatric intensive care unit]]></kwd>
<kwd lng="en"><![CDATA[Lymphopenia]]></kwd>
<kwd lng="en"><![CDATA[Hypogammaglobulinemia]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cui]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Wei]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Lv]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock:a meta-analysis with trial sequential analysis]]></article-title>
<source><![CDATA[Annals of Intensive Care]]></source>
<year>2019</year>
<volume>9</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Greathouse]]></surname>
<given-names><![CDATA[KC]]></given-names>
</name>
<name>
<surname><![CDATA[Hall]]></surname>
<given-names><![CDATA[MW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Critical illness-induced immune suppression:current state of the science]]></article-title>
<source><![CDATA[American Journal of Critical Care]]></source>
<year>2015</year>
<volume>25</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>85-92</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pfortmueller]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Meisel]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Fux]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Schefold]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Assessment of immune organ dysfunction in critical illness:utility of innate immune response markers]]></article-title>
<source><![CDATA[ICMx]]></source>
<year>2017</year>
<volume>5</volume>
<numero>49</numero>
<issue>49</issue>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mathews]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rajan]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Soans]]></surname>
<given-names><![CDATA[ST]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prognostic value of rise in neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in predicting the mortality in paediatric intensive care]]></article-title>
<source><![CDATA[Int J Contemp Pediatr]]></source>
<year>2019</year>
<volume>6</volume>
<page-range>1052-8</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Monserrat]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[de Pablo]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Reyes]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Barcenilla]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Zapata]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical relevance of the severe abnormalities of the T cell compartment in septic shock patients]]></article-title>
<source><![CDATA[Crit Care]]></source>
<year>2009</year>
<volume>13</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>R26</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Venet]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Gebeile]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Bancel]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Guignant]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Poitevin-Later]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Malcus]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Assessment of plasmatic immunoglobulin G, A and M levels in septic shock patients]]></article-title>
<source><![CDATA[International Immunopharmacology]]></source>
<year>2011</year>
<volume>11</volume>
<page-range>2086-90</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Andaluz-Ojeda]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Iglesias]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Bobillo]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Almansa]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Rico]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Gandía]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Early natural killer cell counts in blood predict mortality in severe sepsis]]></article-title>
<source><![CDATA[Critical Care]]></source>
<year>2011</year>
<volume>15</volume>
<page-range>R243</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Taccone]]></surname>
<given-names><![CDATA[FS]]></given-names>
</name>
<name>
<surname><![CDATA[Stordeur]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[De Backer]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Creteur]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Vincent]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Globulin levels in patients with community-acquired septic shock]]></article-title>
<source><![CDATA[Shock]]></source>
<year>2009</year>
<volume>32</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>379-85</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Goldstein]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Giroir]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Randolph]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Miembros de la Conferencia de consenso internacional sobre sepsis pediátrica:definiciones de sepsis y disfunción orgánica en pediatría*, Medicina de cuidados intensivos pediátricos]]></article-title>
<source><![CDATA[]]></source>
<year>2005</year>
<volume>6</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>2-8</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hauser]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
<name>
<surname><![CDATA[Chan]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Casey]]></surname>
<given-names><![CDATA[WF]]></given-names>
</name>
<name>
<surname><![CDATA[Midgley]]></surname>
<given-names><![CDATA[FM]]></given-names>
</name>
<name>
<surname><![CDATA[Holbrook]]></surname>
<given-names><![CDATA[PR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Immune dysfunction in children after corrective surgery for congenital heart disease]]></article-title>
<source><![CDATA[Critical Care Medicine]]></source>
<year>1991</year>
<volume>19</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>874-81</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Habermehl]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Knuf]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kampmann]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Mannhardt]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Schranz]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Kuroczynski]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Changes in lymphocyte subsets after cardiac surgery in children]]></article-title>
<source><![CDATA[Eur J Pediatr]]></source>
<year>2003</year>
<volume>162</volume>
<page-range>15-21</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Miller]]></surname>
<given-names><![CDATA[BE]]></given-names>
</name>
<name>
<surname><![CDATA[Levy]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The inflammatory response to cardiopulmonary bypass]]></article-title>
<source><![CDATA[J Cardiothorac Vasc Anesth]]></source>
<year>1997</year>
<volume>11</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>355-66</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jiménez-Aguilar]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez-Zauco]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Tiburcio-Felix]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[JZ]]></given-names>
</name>
<name>
<surname><![CDATA[Solano-Gutiérrez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Riera]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of cardiopulmonary bypass on the development of lymphopenia and sepsis after cardiac surgery in children with congenital cardiopathy]]></article-title>
<source><![CDATA[Experimental and Therapeutic Medicine]]></source>
<year>2020</year>
<volume>19</volume>
<page-range>435-42</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jones]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[McCracken]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Alsoufi]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Mahle]]></surname>
<given-names><![CDATA[WT]]></given-names>
</name>
<name>
<surname><![CDATA[Oster]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Association of preoperative cell counts with outcomes after operation for congenital heart disease]]></article-title>
<source><![CDATA[Ann Thorac Surg]]></source>
<year>2018</year>
<volume>106</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1234-40</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hall]]></surname>
<given-names><![CDATA[MW]]></given-names>
</name>
<name>
<surname><![CDATA[Knatz]]></surname>
<given-names><![CDATA[NL]]></given-names>
</name>
<name>
<surname><![CDATA[Vetterly]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Tomarello]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Wewers]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
<name>
<surname><![CDATA[Volk]]></surname>
<given-names><![CDATA[HD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome]]></article-title>
<source><![CDATA[Intensive Care Medicine]]></source>
<year>2011</year>
<volume>37</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>525-32</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hohlstein]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Gussen]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Bartneck]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Warzecha]]></surname>
<given-names><![CDATA[KT]]></given-names>
</name>
<name>
<surname><![CDATA[Roderburg]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Buendgens]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prognostic relevance of altered lymphocyte subpopulations in critical illness and sepsis]]></article-title>
<source><![CDATA[J Clin Med]]></source>
<year>2019</year>
<volume>8</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>353</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Le Tulzo]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Pangault]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Gacouin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Guilloux]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Tribut]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Amiot]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome]]></article-title>
<source><![CDATA[Shock]]></source>
<year>2002</year>
<volume>18</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>487-94</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hibbert]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[Currie]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Strunk]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sepsis-induced immunosuppression in neonates]]></article-title>
<source><![CDATA[Frontiers in Pediatrics]]></source>
<year>2018</year>
<volume>357</volume>
</nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Taccone]]></surname>
<given-names><![CDATA[FS]]></given-names>
</name>
<name>
<surname><![CDATA[Stordeur]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[De Backer]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Creteur]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Vincent]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Gamma-globulin levels in patients with community-acquired septic shock]]></article-title>
<source><![CDATA[Shock]]></source>
<year>2009</year>
<volume>32</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>379-85</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rojas]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Asociación entre valores de inmunoglobulinas y gravedad de sepsis en pacientes con sepsis en la Unidad de Cuidados Intensivos Pediátricos del Hospital Universitario Clínica San Rafael durante el periodo de primero julio 2010 al 30 de junio de 2011 [Tesis de Especialización, Universidad Militar Nueva Granada]]]></article-title>
<source><![CDATA[Repositorio Institucional-Universidad Militar Nueva Granada]]></source>
<year>2012</year>
</nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Daix]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Guerin]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Tavernier]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Mercier]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Gissot]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Hérault]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<collab>Septiflux Trial Group</collab>
<article-title xml:lang=""><![CDATA[Multicentric standardized flow cytometry routine assessment of patients with sepsis to predict clinical worsening]]></article-title>
<source><![CDATA[Chest]]></source>
<year>2018</year>
<volume>154</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>617-27</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cui]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Long]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[CD8? T-cell counts:an early predictor of risk and mortality in critically ill immunocompromised patients with invasive pulmonary aspergillosis]]></article-title>
<source><![CDATA[Crit Care]]></source>
<year>2013</year>
<volume>17</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>R157</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
