<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-8748</journal-id>
<journal-title><![CDATA[Acta Neurológica Colombiana]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Neurol Colomb.]]></abbrev-journal-title>
<issn>0120-8748</issn>
<publisher>
<publisher-name><![CDATA[Asociación Colombiana de Neurología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-87482013000400001</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Primera crisis febril como manifestación de meningitis en lactantes]]></article-title>
<article-title xml:lang="en"><![CDATA[First febrile seizure as manifestation of meningitis in infancy]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Espinosa]]></surname>
<given-names><![CDATA[Eugenia]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Universidad Militar Nueva Granada  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2013</year>
</pub-date>
<volume>29</volume>
<numero>4</numero>
<fpage>227</fpage>
<lpage>228</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-87482013000400001&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-87482013000400001&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-87482013000400001&amp;lng=en&amp;nrm=iso"></self-uri></article-meta>
</front><body><![CDATA[  <font face="Verdana" size="2">      <p align="center"><font size="4"><b>Primera crisis febril como manifestaci&oacute;n de    meningitis en lactantes</b></font></p>     <p align="center"><font size="3"><b><i>First febrile seizure as manifestation of    meningitis in infancy</i></b></font></p>      <p align="center">Eugenia Espinosa </p>     <p>Eugenia Espinosa MD. Pediatra-Neur&oacute;logo Pediatra. Profesora Titular Universidad Militar Nueva Granada. Bogot&aacute;, Colombia</p>     <p>Correspondencia: <a href="mailto:maria.rubio@correounivalle.edu.co">maria.rubio@correounivalle.edu.co</a> <a href="mailto:mherubio@gmail.com">mherubio@gmail.com</a></p>     <p>Recibido: 12/11/13. Revisado: 20/11/13. Aceptado: 21/11/13.</p> <hr>      <p>Las convulsiones febriles son una de las patolog&iacute;as neurol&oacute;gicas m&aacute;s frecuentes en los servicios de urgencias en menores de 5 a&ntilde;os, en cualquier nivel de atenci&oacute;n. Una primera crisis febril en menores de 18 meses es un signo neurol&oacute;gico que hace pensar en infecci&oacute;n bacteriana o viral del sistema nervioso central (1). </p>       <p>La historia cl&iacute;nica con una buena anamnesis y antecedentes personales, el esquema de vacunaci&oacute;n y su adecuado cumplimiento, los antecedentes familiares de epilepsia o de crisis febriles, y la historia del desarrollo psicomotor son los factores mas importantes para determinar si existe riesgo de neuroinfecci&oacute;n bacteriana o viral en una primera crisis febril bien sea simple o compleja, y para decidir la realizaci&oacute;n de una punci&oacute;n lumbar especialmente en menores de 18 meses (2,3), sea ella realizada por el pediatra o el m&eacute;dico general </p>      <p>La identificaci&oacute;n de un signo cl&iacute;nico como la presencia de irritaci&oacute;n men&iacute;ngea, hipertensi&oacute;n de la fontanela asociado a irritabilidad, adem&aacute;s de una crisis febril hace necesario descartar infecci&oacute;n del sistema nervioso central en un lactante (4,5). </p>      ]]></body>
<body><![CDATA[<p>En el pa&iacute;s a pesar de las campa&ntilde;as de vacunaci&oacute;n, algunos ni&ntilde;os todav&iacute;a presentan esquemas de vacunaci&oacute;n incompletos, por lo cual hay que estar atentos ante la presencia de fiebre, una primera crisis febril en un lactante y descarta meningitis bacteriana (6,7). </p>      <p>Seg&uacute;n datos del comit&eacute; de vacunaci&oacute;n del Ministerio de Salud, la cobertura de vacunaci&oacute;n contra neumococo, que se inici&oacute; en 2011 en todo el pa&iacute;s, se encuentra cercana al 90%; en los &uacute;ltimos 5 a&ntilde;os no se ha reportado caso alguno de meningitis por <i>Haemophilus influenze </i>tipo b (Hib), y a pesar de una importante reducci&oacute;n, a&uacute;n, se presentan casos de meningitis por <i>Streptococcus penumoniae</i>. </p>       <p>Realizada la punci&oacute;n lumbar la interpretaci&oacute;n del LCR con presencia de pleocitosis, uno de los signos de meningitis bacteriana, debe considerarse junto con otros criterios cl&iacute;nicos para proponer un diagn&oacute;stico etiol&oacute;gico e iniciar un esquema adecuado de antibi&oacute;ticos (1, 8,9). </p>      <p>El art&iacute;culo sobre &ldquo;Frecuencia de meningitis en ni&ntilde;os entre 3 y 18 meses de edad con primer episodio de convulsi&oacute;n febril simple. Experiencia en el Hospital San Vicente Fundaci&oacute;n, Medell&iacute;n&rdquo;; motivo de este editorial; sirve para revisar dos temas de presentaci&oacute;n frecuente en la edad pedi&aacute;trica: las crisis febriles y la meningitis bacteriana. El art&iacute;culo muestra una frecuencia muy baja de meningitis bacteriana con un primer episodio de convulsi&oacute;n febril simple, en un hospital de III nivel, en donde solo se present&oacute; un caso de meningitis bacteriana por <i>Stafilococcus aureus </i>germen poco frecuente en este grupo de edad y contra el cual no existen actualmente vacunas y dos casos de meningitis as&eacute;ptica. </p>      <p>Las recomendaciones dadas por este art&iacute;culo y por la Academia Americana de Pediatr&iacute;a son v&aacute;lidas en Colombia, para sospechar meningitis en ni&ntilde;os menores de 18 meses. A pesar de la baja frecuencia de meningitis bacteriana luego de una primera crisis febril simple o compleja debe alertarse al pediatra sobre la observaci&oacute;n del lactante y la decisi&oacute;n de realizaci&oacute;n de punci&oacute;n lumbar y examen del LCR (1-4). </p>       <p>Se recomienda la punci&oacute;n lumbar y el estudio del LCR en ni&ntilde;os entre 6 y 12 meses, sin inmunizaci&oacute;n o con inmunizaci&oacute;n incompleta contra <i>Haemophilus </i><i>influenzae </i>tipo b (Hib) y <i>Streptococcus pneumoniae</i>, en casos de lactantes con presencia de signos men&iacute;ngeos al examen f&iacute;sico, y en aquellos ni&ntilde;os que han recibido previamente antibi&oacute;ticos, ante la posibilidad del enmascaramiento de los signos cl&iacute;nicos en casos de meningitis bacteriana parcialmente tratada (10). El uso racional de los antibi&oacute;ticos en patolog&iacute;as extraneurol&oacute;gicas evita el diagn&oacute;stico de meningitis parcialmente tratada. </p>       <p>La meningitis bacteriana es una condici&oacute;n cl&iacute;nica grave en cualquier &eacute;poca de la vida, la sospecha diagn&oacute;stica, lleva a la realizaci&oacute;n de punci&oacute;n lumbar y estudio del l&iacute;quido cefalorraqu&iacute;deo, de cultivos, y a la indicaci&oacute;n de un tratamiento razonable. A pesar del diagn&oacute;stico y tratamiento oportuno en ocasiones se registran complicaciones m&eacute;dicas en el episodio agudo, o se presentan secuelas que pueden incluir diferentes grados de discapacidad especialmente en los ni&ntilde;os peque&ntilde;os como: epilepsia, hipoacusia, retardo mental o par&aacute;lisis cerebral (11,12). </p> <hr>     <p><font size="3"><b>REFERENCIAS</b></font></p>      <!-- ref --><p>1. BATRA P, GUPTA S, GOMBER S, SAHA A. Predictors of meningitis in children presenting with first febrile seizures. <i>Pediatric Neurology.</i> 2011; 44:35-9.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000021&pid=S0120-8748201300040000100001&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --> </p>      ]]></body>
<body><![CDATA[<!-- ref --><P>2. Joint Working Group of the Research Unit of Royal College of Physicians and the British Paediatric Association. Guidelines for the management of convulsions with fever. <i>BMJ </i>1991; 303: 634-6.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000023&pid=S0120-8748201300040000100002&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></p>      <!-- ref --><P>3. DUFFNER P, BERMAN P, GRAHAM P, GREEN J, SCHNEIDER S.</b> Subcommittee on febrile seizures. Clinical febrile seizures: Guideline for the neurodiagnostic evaluation of the with a simple febrile seizures. <i>Pediatrics </i>2011; 127:389-394.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000025&pid=S0120-8748201300040000100003&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></p>      <!-- ref --><P>4. SHAKED O, PE&Ntilde;A B, LINARES M, BARKER R. </b>Simple febrile seizures: Are the AAP guidelines regarding lumbar puncture being followed?. <i>Ped Emerg Care. </i>2009; 25:8-11.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000027&pid=S0120-8748201300040000100004&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></p>       <!-- ref --><p>5. TRAINOR JL, HAMPERS LC, KRUG SE, LISTERNICK R. Children with first-time simple febrile seizures are at low risk of serious bacterial illness. <i>Acad Emerg Med </i>2001;8:781-7.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000029&pid=S0120-8748201300040000100005&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --> </p>      <!-- ref --><p>6. Worlf Health. Pneumococcal vaccines. The Weekly Epidemiological Record. 2003:14:110-9.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000031&pid=S0120-8748201300040000100006&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --> </p>       ]]></body>
<body><![CDATA[<!-- ref --><p>7. KIMIA AA, CAPRARO AJ, HUMMEL D, JOHNSTON P, HARPER MB. Utility of lumbar puncture for first simple febrile seizure among children 6 to 18 months of age. <i>Pediatrics </i>2009 ;123:6-12.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000033&pid=S0120-8748201300040000100007&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --> </p>      <!-- ref --><p>8. NEUMANN MI, TOLFORD S, HARPER MB. Test characteristics and interpretation of cerebrospinal fluid Gram stain in children. <i>Pediatr Infect Dis J. </i>2008;27:309-13.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000035&pid=S0120-8748201300040000100008&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --> </p>      <!-- ref --><p>9. PROBER CG, DYNER L. Central nervous system infections. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, Eds. Nelson Textbook of Pediatrics. 19th Ed. Philadelphia: Saunders Elsevier; 2011: 595.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000037&pid=S0120-8748201300040000100009&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --> </p>       <!-- ref --><p>10. STOCKMANN C, AMPOFO K, BYINTON C, FELLOUX F, HERSH A, BLASCHKE A, COWAN  P. Pneumococcal miningitis in children: epidemiology, serotypes and outcome from 1997-2010 in Utah. Pediatrics 2013; 132:421-8.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000039&pid=S0120-8748201300040000100010&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --> </p>       <!-- ref --><P>11. CLARK A, GRIFFITHS U, ABBAS S, RAO K, PRIVOR. DUMM L, ET ALS.</b> Impact and costeffectiviness of haemophilus infuenze tipo b conjugate vaccination in India. <i>J Pediatr </i>2013;163 (1 suppl):s60-72.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000041&pid=S0120-8748201300040000100011&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></p>      ]]></body>
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