<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0121-0807</journal-id>
<journal-title><![CDATA[Revista de la Universidad Industrial de Santander. Salud]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Univ. Ind. Santander. Salud]]></abbrev-journal-title>
<issn>0121-0807</issn>
<publisher>
<publisher-name><![CDATA[Universidad Industrial de Santander]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0121-08072017000400535</article-id>
<article-id pub-id-type="doi">10.18273/revsal.v49n4-2017002</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Niveles de eritropoyetina y reticulocitos en residentes de bajas alturas migrantes a medianas alturas]]></article-title>
<article-title xml:lang="en"><![CDATA[Erythropoietin and reticulocyte levels in lowland residents migrating to middle altitudes]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peralta González]]></surname>
<given-names><![CDATA[Manuel Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zanguña Fonseca]]></surname>
<given-names><![CDATA[Luisa Fernanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz Rubio]]></surname>
<given-names><![CDATA[Shirley Gigiola]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Boyacá  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<volume>49</volume>
<numero>4</numero>
<fpage>535</fpage>
<lpage>539</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0121-08072017000400535&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0121-08072017000400535&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0121-08072017000400535&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: La eritropoyetina es una alfa globulina glicosilada con producción renal en más del 90% en la vida adulta. Es la principal hormona en el mantenimiento constante de la masa eritrocitaria, aunque existen modificaciones en sus niveles asociados con el tabaquismo, anemias, EPOC y la migración de bajas a medianas o altas alturas. Esto último desencadena un proceso hipóxico que puede llegar a producir mal agudo de montaña.  Objetivo:  Describir el comportamiento de la eritropoyetina, el recuento de reticulocitos y su influencia, en procesos de adaptación a la altura.  Metodología:  Estudio descriptivo de corte transversal que incluyó 11 participantes provenientes de bajas alturas a quienes se les determinó la concentración sérica de eritropoyetina y el recuento de reticulocitos en un periodo de 28 días.  Resultados:  Ocho de los participantes presentaron un ascenso progresivo en los niveles séricos de eritropoyetina, uno mantuvo una curva plana y dos presentaron comportamiento atípico respecto a lo reportado en la literatura.  Conclusión:  La eritropoyetina es un factor fundamental que marca el comienzo de la eritropoyesis, cuya finalidad es mejorar el aporte de oxígeno en procesos de adaptación a la altura. Además, la hipoxia es un factor determinante en el inicio y desarrollo del mal agudo de montaña. El recuento de reticulocitos depende del estímulo proliferativo y anti-apoptótico de la eritropoyetina, así como de las concentraciones séricas de vitamina B12, hierro y ácido fólico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  EPO is a glycosylated alpha globulin produced in more than 90% by kidneys through adult life, being a key hormone that regulated the erythrocytic mass. However, there are some modifications in the levels of this hormone that may be related to smoking, anemia, EPOC and migration to from low to higher altitudes, inducing hypoxic processes. Depending on the individual, it may produced the disease named as acute mountain sickness.  Objective: To describe erythropoietin level modifications, reticulocytes count and its influence, on the adaptive process to altitude.  Methodology:  This is a transversal descriptive study including 11 participants from low altitudes places, whose EPO serum concentration and reticulocytes count was determined during 28 days.  Results:  Eight participants presented a progressive increase in EPO serum levels, one participant exhibited a constant level and two more showed atypical results according to previous literature.  Conclusion: EPO is a key factor for determining the erythropoiesis beginning, as its objective is to improve the oxygen provision during altitude adaptation processes by increasing its concentration in blood due to hypoxic stimulus. Besides, hypoxia is a determinant factor in the beginning and development of acute mountain sickness. The reticulocytes count depends also on the EPO proliferative and anti-apoptotic stimulus, and on the serum concentrations of B12 vitamin, iron and folic acid.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Eritropoyetina]]></kwd>
<kwd lng="es"><![CDATA[reticulocitos]]></kwd>
<kwd lng="es"><![CDATA[hipoxia]]></kwd>
<kwd lng="es"><![CDATA[eritropoyesis]]></kwd>
<kwd lng="es"><![CDATA[altura]]></kwd>
<kwd lng="en"><![CDATA[Erythropoietin]]></kwd>
<kwd lng="en"><![CDATA[reticulocytes]]></kwd>
<kwd lng="en"><![CDATA[hypoxia]]></kwd>
<kwd lng="en"><![CDATA[Erythropoiesis]]></kwd>
<kwd lng="en"><![CDATA[altitude]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marsden]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Erythropoietin- measurement and clinical applications]]></article-title>
<source><![CDATA[Ann Clin Biochem]]></source>
<year>2006</year>
<volume>43</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>97-104</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aguilera]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Eritropoyetina humana recombinante]]></article-title>
<source><![CDATA[Departamento de investigacion y Desarrollo]]></source>
<year>1988</year>
<volume>7</volume>
<page-range>5-10</page-range><publisher-loc><![CDATA[Biseden ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jelkman]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The disparate roles of cobalt in erytropoiesis and doping relevance]]></article-title>
<source><![CDATA[O J Hematol]]></source>
<year>2012</year>
<volume>3</volume>
<page-range>3-6</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wagner]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[El factor HIF-1 inducido por la hipoxia y la sensibilidad al oxígeno. Rol del hierro intracelular]]></article-title>
<source><![CDATA[Acta Méd. Peruana]]></source>
<year>2011</year>
<volume>28</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cabrera García]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Ruíz Antorán]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Sancho López]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Eritropoyetina revision de indicaciones]]></article-title>
<source><![CDATA[Inf Ter Sist Nac salud]]></source>
<year>2009</year>
<volume>33</volume>
<page-range>3-9</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stuart]]></surname>
<given-names><![CDATA[Ira]]></given-names>
</name>
</person-group>
<source><![CDATA[Fisiología Humana]]></source>
<year>2014</year>
<edition>12a</edition>
<page-range>1-810</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Calderon Velez]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[El Factor Inducible Por la hipoxia y la actividad fisica]]></article-title>
<source><![CDATA[Iatreia]]></source>
<year>2007</year>
<volume>20</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>160-6</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vargas Pinilla]]></surname>
<given-names><![CDATA[OC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Exercise and training at altitudes: physiological effects and protocols]]></article-title>
<source><![CDATA[Rev Cienc Salud]]></source>
<year>2014</year>
<page-range>115-30</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wagner Grau]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[El factor HIF-1 inducido por la hipoxia y la sensibilidad al oxígeno. Rol del hierro intracelular]]></article-title>
<source><![CDATA[Act Méd Peruana]]></source>
<year></year>
<volume>28</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>8-163</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[HH]]></given-names>
</name>
<name>
<surname><![CDATA[Han]]></surname>
<given-names><![CDATA[CL]]></given-names>
</name>
<name>
<surname><![CDATA[Yan]]></surname>
<given-names><![CDATA[HC]]></given-names>
</name>
<name>
<surname><![CDATA[Kao]]></surname>
<given-names><![CDATA[WY]]></given-names>
</name>
<name>
<surname><![CDATA[Tsai]]></surname>
<given-names><![CDATA[CD]]></given-names>
</name>
<name>
<surname><![CDATA[Yen]]></surname>
<given-names><![CDATA[DHT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Oxidative stress and erythropoietin response in altitude exposure]]></article-title>
<source><![CDATA[Clin Investig Med]]></source>
<year>2008</year>
<volume>31</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>E380-5</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Rubio]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Interacción fisiológica de la hormona eritropoyetina, relacionada con el ejercicio físico en altitud moderada y alta]]></article-title>
<source><![CDATA[Rev Investig Salud Univ Boyacá]]></source>
<year>2016</year>
<volume>1</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>73-96</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cardenas]]></surname>
<given-names><![CDATA[DG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fisiología de las grandes alturas]]></article-title>
<source><![CDATA[Fisiol Ren Altura]]></source>
<year>2011</year>
<page-range>7-14</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chapman]]></surname>
<given-names><![CDATA[RF]]></given-names>
</name>
<name>
<surname><![CDATA[Stray-Gundersen]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Levine]]></surname>
<given-names><![CDATA[BD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Individual variation in response to altitude training]]></article-title>
<source><![CDATA[J Appl Physiol]]></source>
<year>1998</year>
<volume>85</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1448-56</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Friedmann-Bette]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Classical altitude training]]></article-title>
<source><![CDATA[Scand J Med Sci Sports]]></source>
<year>2008</year>
<volume>18</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>11-20</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tobergte]]></surname>
<given-names><![CDATA[DR]]></given-names>
</name>
<name>
<surname><![CDATA[Curtis]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fisiologia medica]]></article-title>
<source><![CDATA[J Chem Inf Modeling]]></source>
<year>2013</year>
<volume>53</volume>
<page-range>1689-99</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Riveros]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez Godoy]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Buitrago]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Cristancho]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evidencia del comportamiento circadiano de la EPO con dependencia del sexo e independencia de parámetros fisiológicos en jóvenes entrenados en la altura moderada]]></article-title>
<source><![CDATA[Rev Med]]></source>
<year>2014</year>
<volume>22</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>37-48</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jelkmann]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Regulation of erythropoietin production]]></article-title>
<source><![CDATA[J Physiol]]></source>
<year>2011</year>
<volume>589</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1251-8</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
