<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0123-3475</journal-id>
<journal-title><![CDATA[Revista Colombiana de Biotecnología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. biotecnol]]></abbrev-journal-title>
<issn>0123-3475</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Biotecnología, Universidad Nacional de Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0123-34752018000200089</article-id>
<article-id pub-id-type="doi">10.15446/rev.colomb.biote.v20n2.73668</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Proteínas de Bacillus thuringiensis con actividad citotóxica: Parasporinas]]></article-title>
<article-title xml:lang="en"><![CDATA[Proteins of Bacillus thuringiensis with cytotoxic activity: Parasporins]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Velasquez C.]]></surname>
<given-names><![CDATA[Luisa-Fernanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas T.]]></surname>
<given-names><![CDATA[Dan'ithza S.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cerón S.]]></surname>
<given-names><![CDATA[Jairo A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Colombia  ]]></institution>
<addr-line><![CDATA[Bogotá D.C]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Colombia Instituto de Biotecnología ]]></institution>
<addr-line><![CDATA[Bogotá D.C]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional de Colombia  ]]></institution>
<addr-line><![CDATA[Bogotá D.C]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>20</volume>
<numero>2</numero>
<fpage>89</fpage>
<lpage>100</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-34752018000200089&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0123-34752018000200089&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0123-34752018000200089&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Las toxinas Cry de Bacillus thuringiensis (Bt) han sido reconocidas por su acción biocontroladora contra insectos plaga. Recientemente se ha descrito que algunas cepas de Bt codifican proteínas que no presentan actividad insecticida, pero al ser enfrentadas a líneas celulares de cáncer de diferentes tipos han demostrado actividad citotóxica. Estas proteínas han sido denominadas parasporinas (PS) y surgen como una potencial alternativa para el tratamiento del cáncer debido a que presentan citotoxicidad hacia diferentes líneas celulares cancerígenas y baja o nula citotoxicidad hacia células normales.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Cry toxins from Bacillus thuringiensis (Bt) have been recognized for their biocontrol action against insect pests. Recently it has been described some strains of Bt produce proteins without insecticidal activity, but when cancer cell lines of different types are exposed to these proteins they have demonstrated cytotoxic activity. These proteins have been called parasporins (PS) and are a potential alternative for the treatment of cancer because they have high cytotoxicity in different cancer cell lines, and null or low toxic activity in normal cells.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cáncer]]></kwd>
<kwd lng="es"><![CDATA[línea celular]]></kwd>
<kwd lng="es"><![CDATA[receptor]]></kwd>
<kwd lng="es"><![CDATA[toxina Cry]]></kwd>
<kwd lng="en"><![CDATA[Cancer]]></kwd>
<kwd lng="en"><![CDATA[cellular line]]></kwd>
<kwd lng="en"><![CDATA[receptor]]></kwd>
<kwd lng="en"><![CDATA[toxin Cry]]></kwd>
</kwd-group>
</article-meta>
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