<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1794-1237</journal-id>
<journal-title><![CDATA[Revista EIA]]></journal-title>
<abbrev-journal-title><![CDATA[Rev.EIA.Esc.Ing.Antioq]]></abbrev-journal-title>
<issn>1794-1237</issn>
<publisher>
<publisher-name><![CDATA[Escuela de ingenieria de Antioquia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1794-12372020000200338</article-id>
<article-id pub-id-type="doi">10.24050/reia.v17i34.1410</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Diseño y construcción de un equipo estimulador de campo eléctrico tipo capacitivo para estimulación celular]]></article-title>
<article-title xml:lang="en"><![CDATA[Design and construction capacitive electric field equipment for cell stimulation]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Orozco-Vásquez]]></surname>
<given-names><![CDATA[Juan Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Grisales-Díaz]]></surname>
<given-names><![CDATA[Juan Felipe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Roldán-Vasco]]></surname>
<given-names><![CDATA[Sebastián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ossa-Orozco]]></surname>
<given-names><![CDATA[Claudia Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Restrepo-Múnera]]></surname>
<given-names><![CDATA[Luz Marina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moncada-Acevedo]]></surname>
<given-names><![CDATA[María Elena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Tecnológico Metropolitano  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Antioquia  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<volume>17</volume>
<numero>34</numero>
<fpage>338</fpage>
<lpage>348</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S1794-12372020000200338&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S1794-12372020000200338&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S1794-12372020000200338&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La búsqueda de alternativas para tratamientos al cáncer que puedan ser de bajo costo, menos invasivos y con menores efectos secundarios, sigue siendo un tema de continuo interés. El estudio de un sistema combinado de campos eléctricos de bajo voltaje con nanomateriales, estos últimos actuando como nanovectores, en el tratamiento de cáncer ha mostrado resultados prometedores. En este trabajo se presenta el diseño, simulación y construcción de un equipo estimulador eléctrico tipo capacitivo de bajo voltaje para estimular células tipo fibrobastos normales y tipo melanoma combinadas con nanopartículas de oro. El equipo permite variación en voltaje, frecuencia, intensidad de corriente, forma de onda y ciclo de dureza. El diseño fue realizado en la plataforma Arduino Due, llevado a Eagle para el desarrollo PCB y con visualización en pantalla LCD. El generador construido es finalmente conectado a un par de placas paralelas encargadas del campo eléctrico que será inducido. De las variables entregadas por el equipo se encontraron exactitudes inferiores al 1,5% lo que garantiza el cumplimiento técnico del equipo en las variables necesarias.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The searching of options for cancer treatments at low cost, less invasive and with minor side effects is still an interest matter. The study of a combined system of low voltages electric fields with nanomaterials, the latter working as nanovectors, in the cancer treatment has shown promising results. This work presents the design, simulation and construction of an electrical stimulator equipment capacitive type of low voltage for stimulation of healthy skin cells and melanoma type combined with gold nanoparticles. The equipment allows to modify voltage, frequency, current intensity, waveform and duty cycle. The design was performed in Arduino DUE platform, then taken to Eagle to the PCB development and the visualization on a LCD screen. The implemented generator is finally connected to a couple of parallel plates which are in charge of the induced electric field. From the variables delivered by the equipment, accuracies lower than 1.5% were found, this guarantees the technical fulfillment of the equipment in the needed variables.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Estimulación eléctrica]]></kwd>
<kwd lng="es"><![CDATA[Desarrollo de equipos]]></kwd>
<kwd lng="es"><![CDATA[Estimulación capacitiva]]></kwd>
<kwd lng="en"><![CDATA[Electric stimulation instrument]]></kwd>
<kwd lng="en"><![CDATA[Development equipment]]></kwd>
<kwd lng="en"><![CDATA[Capacitive stimulation]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Araujo]]></surname>
<given-names><![CDATA[T. S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Modulation of electrical stimulation applied to human physiology and clinical diagnostic]]></source>
<year>2015</year>
<publisher-loc><![CDATA[Lisboa ]]></publisher-loc>
<publisher-name><![CDATA[Universidade Nova Lisboa. Fundación para la Ciencia y la Tecnología]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Balakatounis]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Angoules]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Low-intensity Electrical Stimulation in Wound Healing: Review of the Efficacy of Externally Applied Currents Resembling the Current of Injury&#8217;]]></article-title>
<source><![CDATA[Journal of Plactic Surgery]]></source>
<year>2008</year>
<numero>8</numero>
<issue>8</issue>
<page-range>283-91</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Camapana]]></surname>
<given-names><![CDATA[LG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Bleomycin-based electrochemotherapy: clinical outcome from a single institution&#8217;s experience with 52 patients&#8217;,]]></article-title>
<source><![CDATA[Ann. Surg. Oncol.]]></source>
<year>2009</year>
<numero>16</numero>
<issue>16</issue>
<page-range>191-9</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cemazar]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Control by pulse parameters of DNA electrotransfer into solid tumors in mice&#8217;]]></article-title>
<source><![CDATA[Gene Ther]]></source>
<year>2009</year>
<numero>16</numero>
<issue>16</issue>
<page-range>635-44</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Esser]]></surname>
<given-names><![CDATA[A.T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Towards solid tumor treatment by irreversible electroporation: intrinsic redistribution of fields and currents in tissue&#8217;]]></article-title>
<source><![CDATA[Technol. Cancer Res. Treat]]></source>
<year>2007</year>
<volume>2007</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>261-74</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gehl]]></surname>
<given-names><![CDATA[J,]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Results of the ESOPE (European Standard Operating Procedures on Electrochemotherapy) study: efficient, highly tolerable and simple palliative treatment of cutaneous and subcutaneousmetastases fromcancers of any histology&#8217;,]]></article-title>
<source><![CDATA[J. Clin. Oncol]]></source>
<year>2006</year>
<numero>24</numero>
<issue>24</issue>
<page-range>s8047</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<collab>Gehl</collab>
<article-title xml:lang=""><![CDATA[&#8216;Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research&#8217;,]]></article-title>
<source><![CDATA[Acta Physiol. Scand]]></source>
<year>2003</year>
<numero>177</numero>
<issue>177</issue>
<page-range>437-47</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gintautas]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Pore disappearance in a cell after electroporation: theoretical simula tion and comparison with experiments&#8217;,]]></article-title>
<source><![CDATA[Biophys]]></source>
<year>1997</year>
<numero>73</numero>
<issue>73</issue>
<page-range>1299-309</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jankovic]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Binic]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Frequency rhythmic electrical modulation system in the treatment of chronic painful leg ulcers&#8217;.]]></article-title>
<source><![CDATA[Arch Dermatol Res]]></source>
<year>2008</year>
<volume>300</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>377-83</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kasivisvanathan]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;A. Thapar, Y. Oskrochi, J. Picard, E.L.S. Leen, Irreversible electroporation for focal ablation at the porta hepatis&#8217;,]]></article-title>
<source><![CDATA[Cardiovasc. Intervent. Radiol]]></source>
<year>2012</year>
<numero>35</numero>
<issue>35</issue>
<page-range>1531-4</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kozinsky]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Static dielectric properties of carbon nanotubes from first princi ples&#8217;,]]></article-title>
<source><![CDATA[Phys. Rev. Lett]]></source>
<year>2006</year>
<numero>96</numero>
<issue>96</issue>
<page-range>166801</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Chemical tumor-targeting of nanoparticles based on metabolic glycoen gineering and click chemistry&#8217;]]></article-title>
<source><![CDATA[ACS Nano]]></source>
<year>2014</year>
<numero>8</numero>
<issue>8</issue>
<page-range>2048-63</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<collab>Lekner</collab>
<article-title xml:lang=""><![CDATA[&#8216;Electroporation in cancer therapy without insertion of electrodes&#8217;]]></article-title>
<source><![CDATA[Phys. Med. Biol]]></source>
<year>2014</year>
<numero>59</numero>
<issue>59</issue>
<page-range>6031-42</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Maeda]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects&#8217;]]></article-title>
<source><![CDATA[Bioconjug. Chem]]></source>
<year>2010</year>
<numero>21</numero>
<issue>21</issue>
<page-range>797-802</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marty]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Electrochemotherapy - an easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: results of ESOPE (European Standard Ope rating Procedures of Electrochemotherapy) study&#8217;]]></article-title>
<source><![CDATA[EJC Suppl]]></source>
<year>2006</year>
<numero>4</numero>
<issue>4</issue>
<page-range>3-13</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Matsumura]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Maeda]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;A new concept for macromolecular therapeutics in cáncer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent SMANCS&#8217;,]]></article-title>
<source><![CDATA[Cancer Res]]></source>
<year>1986</year>
<numero>46</numero>
<issue>46</issue>
<page-range>6387-92</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Miklav&#269;i&#269;]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Electrochemotherapy: technological advancements for efficient electroporation-based treatment of internal tumors&#8217;]]></article-title>
<source><![CDATA[Med. Biol. Eng. Comput]]></source>
<year>2012</year>
<numero>50</numero>
<issue>50</issue>
<page-range>1213-25</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Neumann]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Bioenerg]]></source>
<year>1999</year>
<numero>48</numero>
<issue>48</issue>
<page-range>3-16</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Neumann]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Gene transfer into mouse lyoma cells by electroporation in high electric fields&#8217;,]]></article-title>
<source><![CDATA[EMBO J.]]></source>
<year>1982</year>
<numero>1</numero>
<issue>1</issue>
<page-range>841-5</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pamela]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Electrical Stimulation Therapy Increases Rate of Healing of Pressure Ulcers in Community-Dwelling People With Spinal Cord Injury&#8217;.]]></article-title>
<source><![CDATA[Archives of Physical Medicine and Rehabilitation]]></source>
<year>2010</year>
<volume>91</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>669-78</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[Pei-Chi]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Combining the single-walled carbon nanotubes with low voltaje electrical stimulation to improve accumulation of nanomedicines in tumor for effective cancer therapy&#8217;.]]></article-title>
<source><![CDATA[Journal of Controlled Release]]></source>
<year>2016</year>
<numero>225</numero>
<issue>225</issue>
<page-range>140-51</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Raffa]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Carbon nanotubeenhanced cell electropermeabilisation&#8217;]]></article-title>
<source><![CDATA[Bioelectro chemistry]]></source>
<year>2010</year>
<numero>79</numero>
<issue>79</issue>
<page-range>136-41</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saito]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[&#8216;Physical Properties of Carbon Nanotube&#8217;]]></source>
<year>2010</year>
<numero>2010</numero>
<issue>2010</issue>
<page-range>1-29</page-range><publisher-loc><![CDATA[Lon don ]]></publisher-loc>
<publisher-name><![CDATA[Imperial College Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sano]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Markedly enhanced permeability and retention effects induced by photo-immunotherapy of tumors&#8217;]]></article-title>
<source><![CDATA[ACS Nano]]></source>
<year>2013</year>
<numero>7</numero>
<issue>7</issue>
<page-range>717-24</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Satkauskas]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Effectiveness of tumor electrochemotherapy as a function of electric pulse strength and duration&#8217;,]]></article-title>
<source><![CDATA[Bioelectrochemistry]]></source>
<year>2005</year>
<numero>65</numero>
<issue>65</issue>
<page-range>105-11</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shahini]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Cell electroporation by CNT-featured microfluidic chip&#8217;]]></article-title>
<source><![CDATA[Lab Chip]]></source>
<year>2013</year>
<numero>13</numero>
<issue>13</issue>
<page-range>2585-90</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stylianopoulos]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;EPR-effect: utilizing size-dependent nanoparticle delivery to solid tumors&#8217;,]]></article-title>
<source><![CDATA[Ther. Deliv]]></source>
<year>2013</year>
<numero>4</numero>
<issue>4</issue>
<page-range>421-3</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Titomirov]]></surname>
<given-names><![CDATA[AV]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;In vivo electroporation and stable transformation of skin cells of newborn mice by plasmid DNA&#8217;]]></article-title>
<source><![CDATA[Biochim. Biophys. Acta]]></source>
<year>1991</year>
<volume>1088</volume>
<numero>1991</numero>
<issue>1991</issue>
<page-range>131-4</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Cuschieri, Tumour cell membrane poration and ablation by pulsed low-intensity electric field with carbon nanotubes&#8217;]]></article-title>
<source><![CDATA[Int. J. Mol. Sci]]></source>
<year>2015</year>
<numero>16</numero>
<issue>16</issue>
<page-range>6890-901</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhong]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8216;Ligand-directed active tumor-targeting polymeric nanoparticles for cancer chemotherapy&#8217;]]></article-title>
<source><![CDATA[Biomacromolecules]]></source>
<year>2014</year>
<numero>15</numero>
<issue>15</issue>
<page-range>1955-69</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
