<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2462-8522</journal-id>
<journal-title><![CDATA[Case reports]]></journal-title>
<abbrev-journal-title><![CDATA[Case reports]]></abbrev-journal-title>
<issn>2462-8522</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional de Colombia (Sede Bogotá), Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2462-85222019000100061</article-id>
<article-id pub-id-type="doi">10.15446/cr.v5nl.75709</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[PEDIATRIC DIABETIC KETOACIDOSIS IN A PATIENT WITH DOWN SYNDROME. CASE REPORT]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Camacho]]></surname>
<given-names><![CDATA[Jhon]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guerrero]]></surname>
<given-names><![CDATA[Daniela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Figueroa]]></surname>
<given-names><![CDATA[Alan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez]]></surname>
<given-names><![CDATA[Leidy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vásquez-Hoyos]]></surname>
<given-names><![CDATA[Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Fundación Universitaria de Ciencias de la Salud Faculty of Medicine Department of Pediatrics]]></institution>
<addr-line><![CDATA[Bogotá D.C]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de San José Pediatric Emergency Service ]]></institution>
<addr-line><![CDATA[Bogotá D.C]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Fundación Universitaria de Ciencias de la Salud Faculty of Medicine Department of Pediatrics]]></institution>
<addr-line><![CDATA[Bogotá D.C]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Fundación Universitaria de Ciencias de la Salud Faculty of Medicine Department of Pediatrics]]></institution>
<addr-line><![CDATA[Bogotá D.C]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<volume>5</volume>
<numero>1</numero>
<fpage>61</fpage>
<lpage>67</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S2462-85222019000100061&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S2462-85222019000100061&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S2462-85222019000100061&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Patients with Down syndrome (DS) have an increased risk of developing autoimmune diseases. This is a rare case of a pediatric patient with DS with an initial clinical profile of diabetic ketoacidosis.  Case presentation: 6-year-old male patient with symptoms suggestive of diabetes mellitus type 1 (DM1) of 15 days of evolution (polyuria, polydipsia, polyphagia and loss of 2 kilos of weight), who was admitted to the emergency department of the Hospital de San José, in Bogotá, Colombia, with uncontrollable vomiting and dehydration. The tests performed confirmed moderate ketoacidosis: glycometry: 592 mg/dL, pH: 7.19, HCO3: 10 mmol/L, PCO2: 45, PO2: 95 and lactic acid: 1.4 mmol/L. Management with isotonic fluids and intravenous insulin therapy was initiated and the patient was transferred to the pediatric intensive care unit, where ketoacidosis was controlled in approximately 10 hours. Subcutaneous insulin schedule was initiated without complications.  Discussion: This case highlights the importance of monitoring possible autoimmune complications in patients with DS, since the risk of developing them is 4.2 times higher than in the general population.  Conclusion: This case calls on to contemplate autoimmune complications in patients with DS during clinical practice. Although they are not part of the most frequent reasons for consultation, they cannot be underestimated and should be suspected and treated in a timely manner.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción. Los pacientes con síndrome de Down (SD) tienen mayor riesgo de enfermedades autoinmunes. A continuación, se presenta un caso inusual de un paciente pediátrico con SD quien debuta con un cuadro de cetoacidosis diabética.  Presentación del caso. Paciente masculino de 6 años con síntomas sugestivos de diabetes mellitus (DM) tipo 1 de 15 días de evolución (poliuria, polidipsia, polifagia y pérdida de 2 kilos de peso), quien ingresa al servicio de urgencias del Hospital de San José, en Bogotá, Colombia, con vómito incoercible y deshidratación. Se realizan exámenes que confirman cuadro de cetoacidosis moderada, glucometría: 592 mg/ dL, pH: 7.19, HCO3: 10 mmol/L, PCO2: 45, PO2: 95 y ácido láctico: 1.4 mmol/L. Se inicia manejo con líquidos isotónicos e insulinoterapia endovenosa y se traslada a la unidad de cuidado intensivo pediátrico, donde se controla la cetoacidosis en un aproximado de 1 0 horas. Se da inicio de esquema de insulina subcutáneo sin complicaciones.  Discusión. Este caso resalta la importancia del seguimiento de posibles complicaciones autoinmunes en pacientes con SD, ya que el riesgo de estas es 4.2 veces mayor en población con SD.  Conclusiones. El presente caso invita a contemplar las complicaciones autoinmunes en pacientes con SD durante la práctica clínica. Si bien no hacen parte de los motivos de consulta más frecuentes, no se pueden subestimar, sino que deben sospecharse y tratarse oportunamente.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Diabetic Ketoacidosis]]></kwd>
<kwd lng="en"><![CDATA[Down syndrome]]></kwd>
<kwd lng="en"><![CDATA[Type 1 Diabetes]]></kwd>
<kwd lng="en"><![CDATA[Pediatrics]]></kwd>
<kwd lng="es"><![CDATA[Cetoacidosis Diabética]]></kwd>
<kwd lng="es"><![CDATA[Síndrome de Down]]></kwd>
<kwd lng="es"><![CDATA[Diabetes Mellitus Tipo 1]]></kwd>
<kwd lng="es"><![CDATA[Pediatría]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guaraldi]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Rossetto-Giaccherino]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Lanfranco]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Motta]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Gori]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Arvat]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Endocrine Autoimmunity in Down's Syndrome]]></article-title>
<source><![CDATA[Front Horm Res]]></source>
<year>2017</year>
<volume>48</volume>
<page-range>133-46</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rosso]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Cecere]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Concolino]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Baserga]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diabetes, hypothyroidism and celiac disease in Down's syndrome. A case report]]></article-title>
<source><![CDATA[Minerva Pediatr]]></source>
<year>1997</year>
<volume>49</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>483-5</page-range><publisher-loc><![CDATA[Italian ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zarante]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Franco]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Frecuencia de malformaciones congénitas: evaluación y pronóstico de 52.744 nacimientos en tres ciudades colombianas]]></article-title>
<source><![CDATA[Biomedica]]></source>
<year>2010</year>
<volume>30</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>65-71</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bergholdt]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Eising]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Nerup]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Pociot]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Increased prevalence of Down's syndrome in individuals with type 1 diabetes in Denmark: A nationwide population-based study]]></article-title>
<source><![CDATA[Diabetologia]]></source>
<year>2006</year>
<volume>49</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1179-82</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shield]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<name>
<surname><![CDATA[Wadsworth]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
<name>
<surname><![CDATA[Hassold]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
<name>
<surname><![CDATA[Judis]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
<name>
<surname><![CDATA[Jacobs]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Is disomic homozygosity at the APECED locus the cause of increased autoimmunity in Down's syndrome?]]></article-title>
<source><![CDATA[Arch Dis Child]]></source>
<year>1999</year>
<volume>81</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>147-50</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schmidt]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Kapellen]]></surname>
<given-names><![CDATA[TM]]></given-names>
</name>
<name>
<surname><![CDATA[Wiegand]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Herbst]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Wolf]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Fröhlich-Reiterer]]></surname>
<given-names><![CDATA[EE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diabetes mellitus in children and adolescents with genetic syndromes]]></article-title>
<source><![CDATA[Exp Clin Endocrinol Diabetes]]></source>
<year>2012</year>
<volume>120</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>579-85</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gillespie]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
<name>
<surname><![CDATA[Dix]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Williams]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Newton]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Robinson]]></surname>
<given-names><![CDATA[ZF]]></given-names>
</name>
<name>
<surname><![CDATA[Bingley]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Islet autoimmunity in children with Down's syndrome]]></article-title>
<source><![CDATA[Diabetes]]></source>
<year>2006</year>
<volume>55</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>3185-8</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aitken]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Mehers]]></surname>
<given-names><![CDATA[KL]]></given-names>
</name>
<name>
<surname><![CDATA[Williams]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[Brown]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bingley]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Holl]]></surname>
<given-names><![CDATA[RW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Early-onset, coexisting autoimmunity and decreased HLA-media-ted susceptibility are the characteristics of diabetes in Down syndrome]]></article-title>
<source><![CDATA[Diabetes Care]]></source>
<year>2013</year>
<volume>36</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1181-5</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wolfsdorf]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Glaser]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Sperling]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diabetic ketoacidosis in infants, children, and adolescents: A consensus statement from the American Diabetes Association]]></article-title>
<source><![CDATA[Diabetes Care]]></source>
<year>2006</year>
<volume>29</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1150-9</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pirgon]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Atabek]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[Sert]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diabetic ketoacidosis, thyroiditis and alopecia areata in a child with Down syndrome]]></article-title>
<source><![CDATA[Indian J Pediatr]]></source>
<year>2009</year>
<volume>76</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1263</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rosenbloom]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The management of diabetic ketoacidosis in children]]></article-title>
<source><![CDATA[Diabetes Ther]]></source>
<year>2010</year>
<volume>1</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>103-20</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brink]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Joel]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Laffel]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[WW]]></given-names>
</name>
<name>
<surname><![CDATA[Olsen]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Phelan]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[ISPAD Clinical Practice Consensus Guidelines 2014. Sick day management in children and adolescents with diabetes]]></article-title>
<source><![CDATA[Pediatr Diabetes]]></source>
<year>2014</year>
<volume>15</volume>
<numero>^s20</numero>
<issue>^s20</issue>
<supplement>20</supplement>
<page-range>193-202</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sherry]]></surname>
<given-names><![CDATA[NA]]></given-names>
</name>
<name>
<surname><![CDATA[Levitsky]]></surname>
<given-names><![CDATA[LL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Management of diabetic ketoacidosis in children and adolescents]]></article-title>
<source><![CDATA[Paediatr Drugs]]></source>
<year>2008</year>
<volume>10</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>209-15</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Verstegen]]></surname>
<given-names><![CDATA[RHJ]]></given-names>
</name>
<name>
<surname><![CDATA[Driessen]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
<name>
<surname><![CDATA[Bartol]]></surname>
<given-names><![CDATA[SJW]]></given-names>
</name>
<name>
<surname><![CDATA[van Noesel]]></surname>
<given-names><![CDATA[CJM]]></given-names>
</name>
<name>
<surname><![CDATA[Boon]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[van der Burg]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Defective B-cell memory in patients with Down syndrome]]></article-title>
<source><![CDATA[J Allergy Clin Immunol]]></source>
<year>2014</year>
<volume>134</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1346-53</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rodrigues]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Debom]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Soares]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Machado]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Pureza]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Peres]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Alterations of ectonucleotidases and acetylcholinesterase activities in lymphocytes of Down syndrome subjects: relation with inflammatory parameters]]></article-title>
<source><![CDATA[Clin Chim Acta]]></source>
<year>2014</year>
<volume>433</volume>
<page-range>105-10</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rohrer]]></surname>
<given-names><![CDATA[TR]]></given-names>
</name>
<name>
<surname><![CDATA[Hennes]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Thon]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Dost]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Grabert]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Rami]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Down's syndrome in diabetic patients aged &lt;20 years: an analysis of metabolic status, glycaemic control and autoimmunity in comparison with type 1 diabetes]]></article-title>
<source><![CDATA[Diabetologia]]></source>
<year>2010</year>
<volume>53</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1070-5</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nespoli]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Burgio]]></surname>
<given-names><![CDATA[GR]]></given-names>
</name>
<name>
<surname><![CDATA[Ugazio]]></surname>
<given-names><![CDATA[AG]]></given-names>
</name>
<name>
<surname><![CDATA[Maccario]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Immunological features of Down's syndrome: a review]]></article-title>
<source><![CDATA[J Intellect Disabil Res]]></source>
<year>1993</year>
<volume>37</volume>
<page-range>543-51</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jiménez-Fadul]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Cortés-Millán]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Enfoque diagnóstico y terapéutico de la cetoacidosis diabética en niños y adolescentes en el servicio de urgencias]]></article-title>
<source><![CDATA[Iatreia]]></source>
<year>2013</year>
<volume>26</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>325-35</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kuppermann]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Ghetti]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Schunk]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[Stoner]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Rewers]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[McManemy]]></surname>
<given-names><![CDATA[JK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>2018</year>
<volume>378</volume>
<numero>24</numero>
<issue>24</issue>
<page-range>227587</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[CP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diabetic Ketoacidosis]]></article-title>
<source><![CDATA[Current Paediatrics]]></source>
<year>2006</year>
<volume>16</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>111-6</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Inward]]></surname>
<given-names><![CDATA[CD]]></given-names>
</name>
<name>
<surname><![CDATA[Chambers]]></surname>
<given-names><![CDATA[TL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fluid manage ment in diabetic ketoacidosis]]></article-title>
<source><![CDATA[Arch Dis Child]]></source>
<year>2002</year>
<volume>86</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>443-4</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fayfman]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pasquel]]></surname>
<given-names><![CDATA[FJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Management of Hyperglycemic Crises: Diabetic Ketoacidosi and Hyperglycemic Hyperosmolar State]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Umpierrez]]></surname>
<given-names><![CDATA[GE]]></given-names>
</name>
</person-group>
<source><![CDATA[Med Cli North Am]]></source>
<year>2017</year>
<volume>101</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>587-606</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wolfsdorf]]></surname>
<given-names><![CDATA[JI]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The International Society of Pediatric and Adolescent Diabetes guidelines for management of diabetic ketoacidosis: Do the guidelines need to be modified?]]></article-title>
<source><![CDATA[Pediatr Diabetes]]></source>
<year>2014</year>
<volume>15</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>277-86</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
