Servicios Personalizados
Revista
Articulo
Indicadores
- Citado por SciELO
- Accesos
Links relacionados
- Citado por Google
- Similares en SciELO
- Similares en Google
Compartir
Revista Facultad de Ingeniería Universidad de Antioquia
versión impresa ISSN 0120-6230versión On-line ISSN 2422-2844
Resumen
GARZON, Diego Alexander; GARCIA, José Manuel y DOBLARE, Manuel. Computer simulation of long bone development: A model of endochondral ossification. Rev.fac.ing.univ. Antioquia [online]. 2008, n.46, pp.58-69. ISSN 0120-6230.
Some bones of the body are constituted by cartilaginous supports in which growth is produced both with the ossification process that extends from the center of the bone towards its borders in a process so called endochondral ossification. In this period of bone tissue morphogenesis the factors controlling the process are mainly biochemical, and the mechanical influence is much lower. This paper presents a simulation model using reaction-diffusion equations for the growth and ossification process in the prenatal bone. It is primarily controlled by an interactive inhibitor-activator loop associated with the parathyroid hormone (PTHrP) and the Indian Hedgehog (Ihh). These equations in combination with the simulation of the proliferative process and the cartilage cell growth (chondrogenesis) lead to a quite accurate simulation of the growth process of a long bone, even predicting the development of secondary ossification centers in the epiphysis.
Palabras clave : Ossification; computer simulation; growth process.