Resumo

MENACA-GUERRERO, Lorena; SUAREZ-CAUSADO, Amileth  e  DIAZ-CABALLERO, Antonio José. Reactive species of oxygen, oxidative stress and its relationship with tissular destruction in periodontitis. CES odontol. [online]. 2020, vol.33, n.2, pp.112-127.  Epub 16-Jul-2021. ISSN 0120-971X.  https://doi.org/10.21615/cesodon.33.2.10.

During periodontitis inflammatory mediators and reactive oxygen species (ROS) are released, when they increase they produce oxidative stress. This review article describes the role played by ROS and oxidative stress in the development and evolution of inflammation and tissue injury during periodontitis. For this, a review of the literature was carried out in databases such as PubMed, ScienceDirect, Wiley Online Library, Springer, Plos one, Nature, Sage journals, Hindawi and Taylor & Francis Online, showing the following results: ROS produce direct damage and indirect to periodontal tissues. Direct damages include lipid peroxidation, protein and DNA oxidation. Indirect damage involves the regulation of signaling pathways of the nuclear transcription factor kappa B (NF-κB), the c-Jun N-terminal kinase pathway (JNK), the pathways of inflammasome and autophagy causing tissue destruction and creation of a pro-inflammatory state in periodontitis.

Palavras-chave : Reactive oxygen species; Oxidative stress; Periodontitis.

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