Abstract

SANDOVAL-CASTRO, Juan José et al. Preferential solvation of tricin in {ethanol (1) + water (2)} mixtures at several temperatures. Rev. colomb. cienc. quim. farm. [online]. 2018, vol.47, n.2, pp.135-148. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v47n2.73933.

The preferential solvation parameters of tricin in {ethanol (1) + water (2)} binary mixtures were obtained from their thermodynamic properties by means of the inverse Kirkwood-Buff integrals method. Tricin is very sensitive to specific solvation effects, so the preferential solvation parameter by ethanol (1), δx 1,3 is negative in the water-rich mixtures but positive in all the other compositions at temperatures from 293.15, to 313.15 K. It is conjecturable that in water-rich mixtures the hydrophobic hydration around the aromatic and methyl groups of the drug plays a relevant role in the solvation. The higher drug solvation by ethanol in mixtures of similar solvent proportions and in ethanol-rich mixtures could be due mainly to polarity effects. In these mixtures, the drug would be acting as Lewis acid with the ethanol molecules because this co-solvent is more basic than water.

Keywords : Tricin; IKBI; ethanol; preferential solvation.

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