Resumo

VAQUIRO-REYES, Ingri Y.; ARAGON-MURIEL, Alberto  e  POLO-CERON, Dorian. Synthesis, characterization and pharmacological evaluation of new metal complexes derived from heteroaromatic hybrids (benzimidazole/oxadiazole). Rev. colomb. cienc. quim. farm. [online]. 2019, vol.48, n.3, pp.557-588.  Epub 03-Nov-2020. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v48n3.84959.

This paper reports the synthesis and detailed characterization of lanthanide complexes La(III), Ce(III), Nd(III) y Sm(III) with tridentate ligands derived from heteroaromatic hybrids. The ligands and their metal complexes were characterized by different physicochemical techniques, including elemental and thermogravimetric analysis; UV-Vis, IR, 1H-NMR and 13C-NMR spectroscopy; molar conductance measurements; and mass spectrometry. The spectral data showed that the hybrid ligand behaves as a NOO tridentate ligand through the nitrogen and oxygen atoms of the benzimidazole and oxadiazole rings and the oxygen atom of the carbonyl group. Elemental and thermal analyses indicated that the obtained metal complexes were formed in 1:2 stoichiometry (metal-ligand). The antioxidant capacity of these compounds was evaluated by both DPPH assay and electrochemical measurements (cyclic voltammetry and square wave voltammetry). The results showed that the metal complexes have higher antioxidant activity compare to the free ligands. Finally, the antibacterial activities of the ligands and their complexes were determined by in vitro tests against Gram-positive bacterial strains and Gram-negative bacterial strains using the broth microdilution method. The metal complexes showed greater antimicrobial activities than the precursor ligands against some of the microorganisms.

Palavras-chave : biological activity; lanthanide complexes; antioxidant activity; antibacterial activity.

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