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Revista Colombiana de Ciencias Químico - Farmacéuticas
Print version ISSN 0034-7418On-line version ISSN 1909-6356
Abstract
TINOCO, Luz Elena; GALINDRES, Diana M.; OSORIO, Jhonny and CARDENAS, Rossember E.. Prediction of sulfamerazine and sulfamethazine solubility in some cosolvent mixtures using non-ideal solution models. Rev. colomb. cienc. quim. farm. [online]. 2021, vol.50, n.1, pp.292-313. Epub Nov 05, 2021. ISSN 0034-7418. https://doi.org/10.15446/rcciquifa.v50n1.95463.
Introduction:
Experimental Solubilities of sulfamerazine (SMR) and sulfamethazine (SMT) in some (methanol + water), (ethanol + water) and (1-propanol + water) cosolvent mixtures were collected from the literature at five temperatures from 293.15 to 313.15 K.
Methodology:
The results were analyzed with the van't Hoff, Apelblat modified, Buchowski-Ksiazaczak λh, van't Hoff-Yaws model, two-parameter Weibull function model. It was determined that the models that best describe the solubility of these sulfonamides in (alcohol + water) mixtures were the van't Hoff and Apelblat models, obtaining correlation indices greater than 0.99 in all cases.
Results:
The results obtained with the Modified Apelblat equation presents a high correlation index for the solubility of SMR and SMT in cosolvent mixtures, followed by the van't Hoff-Yaws model that presents a high fit of the estimated data with respect to the theoretical ones. According to the two-parameter Weibull function model, the solubility ofSMR and SMT in the co-solvent mixtures shows important deviations from ideality, which is consistent with the literature. The results are discussed in terms of the solute-solvent interactions that occur in this system.
Keywords : Sulfamerazine; sulfamethazine; solubility; van't Hoff model; Apelblat modified model; Buchowski-Ksiazaczak 2h model; van't Hoff-Yaws model; two-parameter Weibull function model.
