Abstract

ORTEGA QUINTANA, Fabián Alberto; ALVAREZ, Hernán  and  BOTERO CASTRO, Héctor Antonio. Facing bioprocess modeling: a review of the methodologies of modeling. Rev. ion [online]. 2017, vol.30, n.1, pp.73-90. ISSN 0120-100X.  https://doi.org/10.18273/revion.v30n1-2017006.

This article presents a detailed review of different approaches for process modeling, indicating their deficiencies and limitations when applied to bioprocesses modeling. As a result of the analysis it is concluded that these methodologies fail in bioprocesses modeling because they do not explicitly take into account the interaction between environment and cellular material, at least descriptively. It is noted that so far the way to bring these two worlds has been through purely predictive functions. Finally, the trends in bioprocess model are described; concluding that the approach is oriented to phenomenological based mathematical models with descriptive or explanatory features, to represent the relationship between the cell and its environment.

Keywords : bioprocess; phenomenology; empirical; explicative; descriptive; modeling.

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